19 research outputs found
Palliation of dysphagia with radiotherapy for exophytic base tongue metastases in a case of renal cell carcinoma
Base tongue involvement is a rare presentation of lingual metastases from renal cell carcinoma. A 48-year-old gentleman was treated with open radical nephrectomy and adjuvant radiotherapy for Stage II Furhman grade I clear cell carcinoma of the left kidney at an outside hospital. He presented metachronously 5 years later with progressive dysphagia and change of voice. Clinicoradiological evaluation revealed a large exophytic mass in the oropharynx with epicenter in the right base of tongue. Metastatic workup revealed widespread dissemination to multiple organs and bone. In view of predominant symptom of dysphagia, base tongue metastasis was treated with protracted course of palliative radiotherapy to a dose of 50 Gy in conventional fractionation over 5 weeks. This resulted in excellent and durable response at the base tongue lesion (till the time of last follow-up). Radiation therapy is an acceptable palliative strategy for advanced lingual metastasis as it produces prompt relief of pain, bleeding, and dysphagia
Brain metastases from breast cancer:Management approach
Brain metastases are a significant cause of morbidity and mortality in
patients with breast cancer. HER-2 positivity is an increasingly
recognized risk factor for the development of brain metastases.
Although considerable progress has been made in the treatment of this
complication, supportive measures like steroids, anti-seizure
medication and whole-brain radiation remain the cornerstones of
management in the majority of patients. The current review discusses
the above and other issues like surgical excision, stereotactic
radiotherapy, adjuvant radiation, radiosensitization and chemotherapy.
A brief discussion of the recent evidence for the use of ′HER-1/
HER-2′-targeted therapy is also present
Brain metastases from breast cancer:Management approach
Brain metastases are a significant cause of morbidity and mortality in
patients with breast cancer. HER-2 positivity is an increasingly
recognized risk factor for the development of brain metastases.
Although considerable progress has been made in the treatment of this
complication, supportive measures like steroids, anti-seizure
medication and whole-brain radiation remain the cornerstones of
management in the majority of patients. The current review discusses
the above and other issues like surgical excision, stereotactic
radiotherapy, adjuvant radiation, radiosensitization and chemotherapy.
A brief discussion of the recent evidence for the use of \u2032HER-1/
HER-2\u2032-targeted therapy is also present
Brain metastases from breast cancer:Management approach
Brain metastases are a significant cause of morbidity and mortality in
patients with breast cancer. HER-2 positivity is an increasingly
recognized risk factor for the development of brain metastases.
Although considerable progress has been made in the treatment of this
complication, supportive measures like steroids, anti-seizure
medication and whole-brain radiation remain the cornerstones of
management in the majority of patients. The current review discusses
the above and other issues like surgical excision, stereotactic
radiotherapy, adjuvant radiation, radiosensitization and chemotherapy.
A brief discussion of the recent evidence for the use of ′HER-1/
HER-2′-targeted therapy is also present
The European Organization for Research and Treatment of Cancer prostate-specific quality of life module (PR-25) in Hindi and Marathi: Translation and pilot testing process
Background: The side effects of various treatments for prostate cancer
have a measurable impact on the general as well as disease-related
quality of life, which is of pivotal concern as an outcome measure.
Aim: Translation and pilot testing of the European Organization for
Research and Treatment of Cancer (EORTC) prostate cancer-specific
module (PR-25) into Hindi and Marathi. Materials and Methods: The
translation procedure described by the EORTC was adopted; this
comprised two forward translations of the original English
questionnaire into Hindi and Marathi each with formation of first
intermediary questionnaires and two back translations of the first
intermediary questionnaires into English. The first intermediary
questionnaires were adapted as the second intermediary questionnaires
and pilot tested in ten prostate cancer patients as no modifications
were suggested by the back translators. Results: Each patient, after
completing the questionnaire, was interviewed by the local project
coordinator who questioned them about each item in the second
intermediary questionnaire. The patients were asked whether there was
any difficulty in answering, confusion while answering, or difficulty
in understanding the questions; whether the questions were upsetting;
and if the patients themselves would have framed the question in a
different way. Based on the suggestions or interpretations of this
pilot testing, the necessary changes were incorporated and the final
Hindi and Marathi questionnaires were formed. Conclusion: Both the
translations were submitted to the EORTC for review and have been
subsequently approved for clinical studies
The European Organization for Research and Treatment of Cancer prostate-specific quality of life module (PR-25) in Hindi and Marathi: Translation and pilot testing process
Background: The side effects of various treatments for prostate cancer
have a measurable impact on the general as well as disease-related
quality of life, which is of pivotal concern as an outcome measure.
Aim: Translation and pilot testing of the European Organization for
Research and Treatment of Cancer (EORTC) prostate cancer-specific
module (PR-25) into Hindi and Marathi. Materials and Methods: The
translation procedure described by the EORTC was adopted; this
comprised two forward translations of the original English
questionnaire into Hindi and Marathi each with formation of first
intermediary questionnaires and two back translations of the first
intermediary questionnaires into English. The first intermediary
questionnaires were adapted as the second intermediary questionnaires
and pilot tested in ten prostate cancer patients as no modifications
were suggested by the back translators. Results: Each patient, after
completing the questionnaire, was interviewed by the local project
coordinator who questioned them about each item in the second
intermediary questionnaire. The patients were asked whether there was
any difficulty in answering, confusion while answering, or difficulty
in understanding the questions; whether the questions were upsetting;
and if the patients themselves would have framed the question in a
different way. Based on the suggestions or interpretations of this
pilot testing, the necessary changes were incorporated and the final
Hindi and Marathi questionnaires were formed. Conclusion: Both the
translations were submitted to the EORTC for review and have been
subsequently approved for clinical studies
Treatment Outcomes of Breast Cancer Oligometastatic to Lung and Liver: A Systematic Review and Meta-analysis
We conducted a systematic review of literature and meta-analysis for the studies on local treatment modalities for breast cancer oligometastases (OM) to lung and liver. The objective of the current study was to report survival outcome following optimal local treatment for OM in breast cancer. This would help in baseline assumptions for survival estimates for future prospective trials as well as provide guidelines for patient counselling in clinical practice