Research into the practical and policy applications of soundscape concepts and techniques in urban areas

Executive Summary 1 The aim of this review was to investigate existing research into soundscape concepts and to produce recommendations for future research into the practical identification, management and enhancement of soundscapes in urban areas. 2 Existing research on soundscapes was investigated using four methods: i. a survey of more than 500 papers in the academic literature, ii. an analysis of 27 case studies of soundscape assessment, iii. an analysis of 15 case studies of soundscape design, and iv. interviews with five key soundscape experts. Analysis of this data was conducted to identify significant gaps in the knowledge base and suggest a way of obtaining a practical soundscape assessment method. 3 Soundscapes were found to be a highly multi-disciplinary topic, with many different ideas, concepts, aims and methods evident in the literature. The definition of the term soundscape is itself not settled; for the purposes of this project, we have defined it as “the totality of all sounds within a location with an emphasis on the relationship between individual’s or society’s perception of, understanding of and interaction with the sonic environment.” 4 This review highlights that a range of methodological approaches have been used to establish classifications and categorisations of sounds and soundscapes. The relationship between different categories of sounds and their interaction needs to be considered to increase the understanding of soundscape assessments and to derive soundscape classifications. 5 The different methods and tools used to assess soundscapes, in a variety of locations, each have advantages and disadvantages; using a number of methods in one case study can help to mitigate against the disadvantages of any one method. The case studies assessed in this report demonstrate the importance of individual and demographic similarities/differences, people’s behaviour, physical aspects of the soundscape, other sensory and environmental elements, and the general location and context, in understanding and assessing soundscapes. 6 Soundscape assessments involving a subjective component have highlighted a number of variables that play a part in the assessment. These include the individual’s knowledge and prior experience of the soundscape, the meaning they derive from it, their attitude towards the sound source, their behaviour, their noise sensitivity, demographic and cultural dimensions, and their sense of control over the noise. 7 Research has shown that sometimes a soundscape is perceived as a collection of the individual sounds of which it is comprised; soundscape assessments are therefore related to the assessment of those sound types. This implies that soundscape assessment relies upon the identification of the sounds, the prominence of the sounds, and potentially the ratio of certain sound types to other sound types within the soundscape. It is also highlighted that, because the soundscape varies over time, note must be taken of the fact that any soundscape assessment relates to a singular moment in time. Furthermore, research has shown that soundscape assessments can be dependent on an individual’s memory (when using subjective assessments methods) and/or the segment of the soundscape that was recorded (when playing back recorded soundscapes in a laboratory situation). 8 Multi-sensory experience is also shown to be highly relevant to soundscape assessment and must therefore be acknowledged as soundscapes are not perceived in sensory isolation; in particular audio-visual interactions have been shown to have an effect on soundscape perception. Many researchers point to the importance of understanding the full environmental and social context for soundscape assessment, the relevance of comparing similar place types, and the effect of moving between one soundscape and another on an assessment. 9 Turning to the subject of soundscape design, it is noted that there is a dearth of case studies involving the modification and design of soundscapes, both in the UK and internationally. The rationale behind many of the case studies’ focus upon or consideration of sound was the improvement of a soundscape that was negatively affected by the sound of traffic. Approaches to soundscape design varied, ranging from the use of noise control elements, such as barriers and absorbers, to the utilisation or exploitation of natural elements that already exist in the location. Some case studies introduced sounds to the soundscape, in particular water sounds, while others incorporated specific sonic art installations to alter the soundscape or detract attention from existing features of the soundscape. A number of case studies used design alterations to improve the soundscape and perception of the soundscape including altering visual aspects of the place, altering the layout of the area, pedestrianisation of the area, and providing entertainment facilities (e.g. cafes). 10 Case studies whereby design modifications or interventions have taken place, have had little or no formal evaluation of their success. The studies that were evaluated used a number of different methods involving both objective and subjective measures and included the experimental comparison of subjective ratings, observations of people’s behaviour, recognition and awards for good designs, and level of complaints about the soundscape. This demonstrates that different evaluation tools may be necessary dependent upon the type of soundscape intervention being evaluated. Additionally, by combining methods to produce an interdisciplinary evaluation, a more accurate understanding of the success of the soundscape design is possible, hence improving future interventions. 11 The relationship between environment and individual is complex, with many factors, some of which cannot currently be quantified. Important factors include: prominent individual sound sources, the interaction of sources, other sensory stimuli and contextual and individual factors such as meaning, and expectation. Some of these factors can be captured by subjective rating scales for high-level concepts like ‘calmness’, ‘vibrancy’ and ‘spaciousness’. Other factors, such as the semantic meaning of a soundscape are best characterised currently by qualitative descriptors. There are good prospects for developing objective acoustic metrics to evaluate some factors but in most cases this work is still at an early stage, and the methods developed so far have only been applied in specific contexts; to provide metrics that are more broadly applicable they would need to be evaluated in a broader range of locations and conditions. The expert interviews and case studies illustrated the diversity of views across different disciplines on the most promising soundscape methods. All the interviewees agreed on the need for an interdisciplinary approach, and on the need to retain some form of subjective rating when assessing soundscapes. 12 Ultimately, six important gaps have been identified in the soundscape knowledge base. These are areas where more research would significantly improve understanding soundscape assessments. These gaps have been identified as: i. a lack of genuinely interdisciplinary projects (characterised by a shared perspective) instead of multidisciplinary projects (where researchers work in parallel within their own disciplines). These are needed to deal with the multidimensional experience of soundscape perception. ii. a lack of basic knowledge on many aspects of soundscape cognition, perception and classification. iii.a need for large-scale robust field trials of soundscape assessment methods instead of the more common experiment of a new method in a single location. iv. a need to develop more soundscape-specific indicators and tools that could eventually be used for soundscape design. v. a need to rigorously assess deliberate soundscape interventions to understand which design aspects work and which do not. vi. a lack of a close connection between soundscape research, design and planning practice. 13 Finally, a new research project is proposed to develop a robust field assessment method. The aim of this project is to develop a method based on existing research methods but introducing greater confidence by trialling the method across many real urban soundscapes. Options are presented for developing a purely qualitative assessment tool or one that incorporates and integrates both qualitative and quantitative ratings. 14 We recommend that a first step for an assessment method, which could realistically be developed in the near future, should be based on qualitative methods. A second iteration of this soundscape assessment tool could supplement the qualitative techniques with quantitative methods, first based on subjective rating scales and eventually on objective metrics which predict the subjective ratings

When outcome is a balance: methods to measure combined utility for the choice between induction of labour and expectant management in mild risk pregnancy at term

Background: When the primary and secondary outcomes of clinical studies yield ambiguous or conflicting recommendations, preference or valuation studies may help to overcome the decision problem. The present preference study is attached to two clinical studies (DIGTAT, ISRCT10363217; HYPITAT, ISRCT08132825) that evaluate induction of labour versus expectant management in term pregnancies with a mild risk profile. The purpose of the present study is to compare four methods of valuation/preference measurement. Met

GABA receptor associated protein changes the electrostatic environment around the GABA type A receptor.

Funder: Science and Technology Facilities Council; Id: http://dx.doi.org/10.13039/501100000271We have performed fully atomistic molecular dynamics simulations of the intracellular domain of a model of the GABAA receptor with and without the GABA receptor associated protein (GABARAP) bound. We have also calculated the electrostatic potential due to the receptor, in the absence and presence of GABARAP. We find that GABARAP binding changes the electrostatic properties around the GABAA receptor and could lead to increased conductivity of chloride ions through the receptor. We also find that ion motions that would result in conducting currents are observed nearly twice as often when GABARAP binds. These results are consistent with data from electrophysiological experiments

Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy.

BackgroundHistone deacetylase (HDAC) inhibitors are promising therapeutics for various forms of cardiac diseases. The purpose of this study was to assess cardiac HDAC catalytic activity and expression in children with single ventricle (SV) heart disease of right ventricular morphology, as well as in a rodent model of right ventricular hypertrophy (RVH).MethodsHomogenates of right ventricle (RV) explants from non-failing controls and children born with a SV were assayed for HDAC catalytic activity and HDAC isoform expression. Postnatal 1-day-old rat pups were placed in hypoxic conditions, and echocardiographic analysis, gene expression, HDAC catalytic activity, and isoform expression studies of the RV were performed.ResultsClass I, IIa, and IIb HDAC catalytic activity and protein expression were elevated in the hearts of children born with a SV. Hypoxic neonatal rats demonstrated RVH, abnormal gene expression, elevated class I and class IIb HDAC catalytic activity, and protein expression in the RV compared with those in the control.ConclusionsThese data suggest that myocardial HDAC adaptations occur in the SV heart and could represent a novel therapeutic target. Although further characterization of the hypoxic neonatal rat is needed, this animal model may be suitable for preclinical investigations of pediatric RV disease and could serve as a useful model for future mechanistic studies

Using fractional exhaled nitric oxide (FeNO) to diagnose steroid-responsive disease and guide asthma management in routine care

Acknowledgements We thank Robin Taylor for his informative thinking and publications on FeNO, which have helped to influence and direct the thinking of the authors. Funding Extraction of the real-life dataset was funded by Research in Real Life Limited, the analysis of the dataset and the writing of this manuscript were co-funded (50:50) by Research in Real Life Limited and Aerocrine.Peer reviewedPublisher PD

Galactic and Extragalactic Samples of Supernova Remnants: How They Are Identified and What They Tell Us

Supernova remnants (SNRs) arise from the interaction between the ejecta of a supernova (SN) explosion and the surrounding circumstellar and interstellar medium. Some SNRs, mostly nearby SNRs, can be studied in great detail. However, to understand SNRs as a whole, large samples of SNRs must be assembled and studied. Here, we describe the radio, optical, and X-ray techniques which have been used to identify and characterize almost 300 Galactic SNRs and more than 1200 extragalactic SNRs. We then discuss which types of SNRs are being found and which are not. We examine the degree to which the luminosity functions, surface-brightness distributions and multi-wavelength comparisons of the samples can be interpreted to determine the class properties of SNRs and describe efforts to establish the type of SN explosion associated with a SNR. We conclude that in order to better understand the class properties of SNRs, it is more important to study (and obtain additional data on) the SNRs in galaxies with extant samples at multiple wavelength bands than it is to obtain samples of SNRs in other galaxiesComment: Final 2016 draft of a chapter in "Handbook of Supernovae" edited by Athem W. Alsabti and Paul Murdin. Final version available at https://doi.org/10.1007/978-3-319-20794-0_90-

Differentially expressed genes in a flock of Chinese local-breed chickens infected with a subgroup J avian leukosis virus using suppression subtractive hybridization

Avian leukosis virus subgroup J (ALV-J) is a new type of virus that mainly induces myeloid leukosis (ML) in chickens. To further elucidate the pathogenesis of ALV-J infection and tumor development, expression profiles from the bone marrow tissue of 15 infected and 18 non-infected birds from a local-breed poultry-farm under naturally infected conditions, were analyzed by suppression-subtractive hybridization. The birds were diagnosed as ML+ (or ML-) by specific ALV-J detection methods, involving serological tests for antigens and antibodies, and RT-PCR to detect viral RNA. A total of 59 partial gene sequences were revealed by differential screening of 496 forward and 384 reverse subtracted cDNA clones. Of these, 22 identified genes, including 8 up-regulated and 14 down-regulated, were related to immune functions, these genes being, MHC B-G antigen, translationally-controlled tumor protein (TPT1/TPTC), transferrin and ferritin, hemoglobin and Carbonic anhydrase. Four of the down-regulated genes were selected for further analysis, in view of their predicted roles in infection and immunity by real-time qRT-PCR, using RNA collected from the same birds as those used for SSH. The four genes were expressed at significantly lower levels (p < 0.001) in ALV-J infected birds than in non-infected ones

An Exploration of the Relations between External Representations and Working Memory

It is commonly hypothesized that external representations serve as memory aids and improve task performance by means of expanding the limited capacity of working memory. However, very few studies have directly examined this memory aid hypothesis. By systematically manipulating how information is available externally versus internally in a sequential number comparison task, three experiments were designed to investigate the relation between external representations and working memory. The experimental results show that when the task requires information from both external representations and working memory, it is the interaction of information from the two sources that determines task performance. In particular, when information from the two sources does not match well, external representations hinder instead of enhance task performance. The study highlights the important role the coordination among different representations plays in distributed cognition. The general relations between external representations and working memory are discussed

Phenotypic and genetic analysis of cognitive performance in Major Depressive Disorder in the Generation Scotland:Scottish Family Health Study

Abstract Lower performances in cognitive ability in individuals with Major Depressive Disorder (MDD) have been observed on multiple occasions. Understanding cognitive performance in MDD could provide a wider insight in the aetiology of MDD as a whole. Using a large, well characterised cohort (N = 7012), we tested for: differences in cognitive performance by MDD status and a gene (single SNP or polygenic score) by MDD interaction effect on cognitive performance. Linear regression was used to assess the association between cognitive performance and MDD status in a case-control, single-episode–recurrent MDD and control-recurrent MDD study design. Test scores on verbal declarative memory, executive functioning, vocabulary, and processing speed were examined. Cognitive performance measures showing a significant difference between groups were subsequently analysed for genetic associations. Those with recurrent MDD have lower processing speed versus controls and single-episode MDD (β =  −2.44, p = 3.6 × 10−04; β =  -2.86, p = 1.8 × 10−03, respectively). There were significantly higher vocabulary scores in MDD cases versus controls (β = 0.79, p = 2.0 × 10−06), and for recurrent MDD versus controls (β = 0.95, p  = 5.8 × 10−05). Observed differences could not be linked to significant single-locus associations. Polygenic scores created from a processing speed meta-analysis GWAS explained 1% of variation in processing speed performance in the single-episode versus recurrent MDD study (p = 1.7 × 10−03) and 0.5% of variation in the control versus recurrent MDD study (p = 1.6 × 10−10). Individuals with recurrent MDD showed lower processing speed and executive function while showing higher vocabulary performance. Within MDD, persons with recurrent episodes show lower processing speed and executive function scores relative to individuals experiencing a single episode