899 research outputs found

    Finite temperature strong-coupling expansions for the Kondo lattice model

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    Strong-coupling expansions, to order (t/J)8(t/J)^8, are derived for the Kondo lattice model of strongly correlated electrons, in 1-, 2- and 3- dimensions at arbitrary temperature. Results are presented for the specific heat, and spin and charge susceptibilities.Comment: revtex

    Two-Hole and Four-Hole Bound States in a t-J Ladder at half-filling

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    The two-hole excitation spectrum of the t-J ladder at half-filling is studied using linked-cluster series expansion methods. A rich spectrum of bound states emerges, particularly at small t/Jt/J. Their dispersion relations and coherence lengths are computed, along with the threshold behaviour as the bound states merge into the continuum. A class of 4-hole bound states is also studied, leading to the conclusion that phase separation occurs for t/J≲0.5t/J \lesssim 0.5, in agreement with other studies.Comment: revtex

    Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model

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    Surgery is still the main curative therapeutic modality for breast cancer. Although surgery often results in the successful removal of the primary tumor, its process could increase the risk of metastases of residual cancer cells. Understanding of the connection between breast cancer metastasis and surgical wound will lead to the establishment of a proper treatment strategy for postoperative cancer patient. Aim: To study the influence of surgical procedure on the metastasis of primary breast cancer. Methods: We established MDA-MB-435 human breast cancer xenograft model. Levels of Pro-matrix metalloproteinase 9 (Pro-MMP-9) and vascular endothelial growth factor (VEGF) in host serum and tumors were tested at different time points with ELISA and zymography and correlated to tumor growth and postoperative metastasis. Results: Our study demonstrated surgical wound had promoting effect on tumor growth and pulmonary metastasis of human breast cells, if tumor cells remain in bodies. This effect might be related to the postoperative interaction of cancer and host cells, which resulted in expression of Pro-MMP-9. Surgical process could also increase the VEGF expression in tumor tissues. Conclusions: Surgical wound-produced host Pro-MMP-9 and tumor cell VEGF might be important mediators leading to metastasis of residual breast cancer after surgery.Π₯ирургичСскоС Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ Π΄ΠΎ сих ΠΏΠΎΡ€ остаСтся Π³Π»Π°Π²Π½Ρ‹ΠΌ тСрапСвтичСским ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ΠΎΠΌ ΠΏΡ€ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… Ρ€Π°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹. Π₯отя хирургичСскоС ΡƒΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ Π² Π±ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²Π΅ случаСв достаточно эффСктивно, Π² Ρ‚ΠΎ ΠΆΠ΅ врСмя ΠΎΠ½ΠΎ ΠΌΠΎΠΆΠ΅Ρ‚ ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΡ‚ΡŒ риск мСтастазирования остаточных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΠΊ. ПониманиС связи ΠΌΠ΅ΠΆΠ΄Ρƒ мСтастазированиСм ΠΏΡ€ΠΈ Ρ€Π°ΠΊΠ΅ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΠΈ ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Ρ€Π°Π½ΠΎΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ Π²Ρ‹Π±Ρ€Π°Ρ‚ΡŒ Π½Π°ΠΈΠ»ΡƒΡ‡ΡˆΡƒΡŽ ΡΡ‚Ρ€Π°Ρ‚Π΅Π³ΠΈΡŽ постопСрационного лСчСния. ЦСль: ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΡ‚ΡŒ влияниС хирургичСского Π²ΠΌΠ΅ΡˆΠ°Ρ‚Π΅Π»ΡŒΡΡ‚Π²Π° Π½Π° мСтастазированиС ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ. ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹: Π±Ρ‹Π»Π° создана модСль Ρ€Π°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² Π²ΠΈΠ΄Π΅ ксСнотрансплантата MDA-MB-435. Π£Ρ€ΠΎΠ²Π΅Π½ΡŒ Pro-ΠΌΠ°Ρ‚Ρ€ΠΈΡ‡Π½ΠΎΠΉ ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π·Ρ‹ 9 (Pro-MMP-9) ΠΈ Ρ„Π°ΠΊΡ‚ΠΎΡ€Π° роста эндотСлия сосудов (VEGF) Π² сывороткС Ρ€Π΅Ρ†ΠΈΠΏΠΈΠ΅Π½Ρ‚Π° ΠΈ опухолях ΠΎΡ†Π΅Π½ΠΈΠ²Π°Π»ΠΈΡΡŒ Π² Ρ€Π°Π·Π½Ρ‹Π΅ Π²Ρ€Π΅ΠΌΠ΅Π½Π½Ρ‹Π΅ ΠΏΡ€ΠΎΠΌΠ΅ΠΆΡƒΡ‚ΠΊΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ELISA ΠΈ Π·ΠΈΠΌΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ. ΠŸΡ€ΠΈ этом опрСдСляли Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ корСлляции ΠΌΠ΅ΠΆΠ΄Ρƒ этими ΠΏΠΎΠΊΠ°Π·Π°- ΠΈ Π·ΠΈΠΌΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ. ΠŸΡ€ΠΈ этом опрСдСляли Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ корСлляции ΠΌΠ΅ΠΆΠ΄Ρƒ этими ΠΏΠΎΠΊΠ°Π·Π° ΠΈ Π·ΠΈΠΌΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ. ΠŸΡ€ΠΈ этом опрСдСляли Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ корСлляции ΠΌΠ΅ΠΆΠ΄Ρƒ этими показатСлями, ростом ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΈ постопСрационными мСтастазами. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹: Π±Ρ‹Π»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ опСрационная Ρ€Π°Π½Π° способствуСт росту ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΌΠΎΠ»ΠΎΡ‡Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ‹ ΠΈ Π΅Π΅ ΠΌΠ΅Ρ‚Π°ΡΡ‚Π°Π·ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ Π² Π»Π΅Π³ΠΊΠΈΠ΅ Π² случаС, ΠΊΠΎΠ³Π΄Π° ΠΏΡ€ΠΈ ΡƒΠ΄Π°Π»Π΅Π½ΠΈΠΈ ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ Π² Ρ€Π°Π½Π΅ ΠΎΡΡ‚Π°ΡŽΡ‚ΡΡ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Π΅ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ. Π­Ρ‚ΠΎ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ связано с постопСрационным взаимодСйствиСм ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Ρ… ΠΈ ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰ΠΈΡ… ΠΈΡ… Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΠΊ, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ экспрСссии Pro-MMP-9. Π£Π΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΌΠΎΠΆΠ΅Ρ‚ Ρ‚Π°ΠΊΠΆΠ΅ ΡΠΏΠΎΡΠΎΠ±ΡΡ‚Π²ΠΎΠ²Π°Ρ‚ΡŒ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΡŽ экспрСссии VEGF ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹ΠΌΠΈ ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ. Π’Ρ‹Π²ΠΎΠ΄Ρ‹: Pro-MMP-9, экспрСссируСмый Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ, ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰ΠΈΠΌΠΈ ΠΏΠΎΡΡ‚ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΡƒΡŽ Ρ€Π°Π½Ρƒ, Π° Ρ‚Π°ΠΊΠΆΠ΅ VEGF, ΠΏΡ€ΠΎΠ΄ΡƒΡ†ΠΈΡ€ΡƒΠ΅ΠΌΡ‹ΠΉ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹ΠΌΠΈ ΠΊΠ»Π΅Ρ‚ΠΊΠ°ΠΌΠΈ, ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ Π²Π°ΠΆΠ½Ρ‹ΠΌΠΈ ΠΌΠ΅Π΄ΠΈΠ°Ρ‚ΠΎΡ€Π°ΠΌΠΈ мСтастазирования остаточных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹Ρ… ΠΊΠ»Π΅Ρ‚ΠΎΠΊ послС хирургичСского Π²ΠΌΠ΅ΡˆΠ°Ρ‚Π΅Π»ΡŒΡΡ‚Π²Π°

    Critical Dynamics of Singlet Excitations in a Frustrated Spin System

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    We construct and analyze a two-dimensional frustrated quantum spin model with plaquette order, in which the low-energy dynamics is controlled by spin singlets. At a critical value of frustration the singlet spectrum becomes gapless, indicating a quantum transition to a phase with dimer order. This T=0 transition belongs to the 3D Ising universality class, while at finite temperature a 2D Ising critical line separates the plaquette and dimerized phases. The magnetic susceptibility has an activated form throughout the phase diagram, whereas the specific heat exhibits a rich structure and a power law dependence on temperature at the quantum critical point. We argue that the novel quantum critical behavior associated with singlet criticality discussed in this work can be relevant to a wide class of quantum spin systems, such as antiferromagnets on Kagome and pyrochlore lattices, where the low-energy excitations are known to be spin singlets, as well as to the CAVO lattice and several recently discovered strongly frustrated square-lattice antiferromagnets.Comment: 5 pages, 5 figures, additional discussion and figure added, to appear in Phys. Rev.

    Series study of the One-dimensional S-T Spin-Orbital Model

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    We use perturbative series expansions about a staggered dimerized ground state to compute the ground state energy, triplet excitation spectra and spectral weight for a one-dimensional model in which each site has an S=\case 1/2 spin Si{\bf S}_i and a pseudospin Ti{\bf T}_i, representing a doubly degenerate orbital. An explicit dimerization is introduced to allow study of the confinement of spinon excitations. The elementary triplet represents a bound state of two spinons, and is stable over much of the Brillouine zone. A special line is found in the gapped spin-liquid phase, on which the triplet excitation is dispersionless. The formation of triplet bound states is also investigated.Comment: 9 pages, 9 figure

    Various series expansions for the bilayer S=1/2 Heisenberg antiferromagnet

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    Various series expansions have been developed for the two-layer, S=1/2, square lattice Heisenberg antiferromagnet. High temperature expansions are used to calculate the temperature dependence of the susceptibility and specific heat. At T=0, Ising expansions are used to study the properties of the N\'{e}el-ordered phase, while dimer expansions are used to calculate the ground-state properties and excitation spectra of the magnetically disordered phase. The antiferromagnetic order-disorder transition point is determined to be (J2/J1)c=2.537(5)(J_2/J_1)_c=2.537(5). Quantities computed include the staggered magnetization, the susceptibility, the triplet spin-wave excitation spectra, the spin-wave velocity, and the spin-wave stiffness. We also estimates that the ratio of the intra- and inter-layer exchange constants to be J2/J1≃0.07J_2/J_1\simeq 0.07 for cuprate superconductor YBa2Cu3O6.2YBa_2Cu_3O_{6.2}.Comment: RevTeX, 9 figure

    A REAL TIME MONITORING MODEL OF THE CALCIUM CARBONATE FOULING INDUCTION PERIOD BASED ON THE CONDUCTANCE TITRATION

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    A new method has been developed to monitor the calcium carbonate fouling induction period (CCFIP) in real time. Based on the conductance titration, this paper investigated the forming process of CCFIP by a staticdynamic combined simulation experiment unit. With the help of titration analysis (that is titrimetry), an accurate definition of CCFIP and the corresponding real time monitoring model were built up. The investigation results show that the proposed model applies not only to measure the CCFIP in real time, but also applies to an investigation of the influence of various factors on the CCFIP

    Minimal immersions of closed surfaces in hyperbolic three-manifolds

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    We study minimal immersions of closed surfaces (of genus gβ‰₯2g \ge 2) in hyperbolic 3-manifolds, with prescribed data (Οƒ,tΞ±)(\sigma, t\alpha), where Οƒ\sigma is a conformal structure on a topological surface SS, and Ξ±dz2\alpha dz^2 is a holomorphic quadratic differential on the surface (S,Οƒ)(S,\sigma). We show that, for each t∈(0,Ο„0)t \in (0,\tau_0) for some Ο„0>0\tau_0 > 0, depending only on (Οƒ,Ξ±)(\sigma, \alpha), there are at least two minimal immersions of closed surface of prescribed second fundamental form Re(tΞ±)Re(t\alpha) in the conformal structure Οƒ\sigma. Moreover, for tt sufficiently large, there exists no such minimal immersion. Asymptotically, as tβ†’0t \to 0, the principal curvatures of one minimal immersion tend to zero, while the intrinsic curvatures of the other blow up in magnitude.Comment: 16 page

    Excitation spectrum and ground state properties of the S=1/2 Heisenberg ladder with staggered dimerization

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    We have studied the excitation spectrum of the S=1/2S=1/2 quantum spin ladder with staggered dimerization by dimer series expansions, diagrammatic analysis of an effective interacting Bose gas of local triplets, and exact diagonalization of small clusters. We find that the model has two massive phases, with predominant inter-chain (rung) or intra-chain correlations. The transition from the rung dimer into the intra-chain dimer phase is characterized by softening of the triplet spectrum at k=Ο€k=\pi. The excitation spectrum as well as the spin correlations away from and close to the critical line are calculated. The location of the phase boundary is also determined.Comment: 13 pages, 7 figure

    Hole dynamics and photoemission in a t-J model for SrCu_2(BO_3)_2

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    The motion of a single hole in a t-J model for the two-dimensional spin-gap compound SrCu_2(BO_3)_2 is investigated. The undoped Heisenberg model for this system has an exact dimer eigenstate and shows a phase transition between a dimerized and a Neel phase at a certain ratio of the magnetic couplings. We calculate the photoemission spectrum in the disordered phase using a generalized spin-polaron picture. By varying the inter-dimer hopping parameters we find a cross-over between a narrow quasiparticle band regime known from other strongly correlated systems and free-fermion behavior. The hole motion in the Neel-ordered phase is also briefly considered.Comment: 4 pages, 3 fig
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