Selenium status and association with bone mineral density.

<p>Selenium status and association with bone mineral density.</p

Patterns of expression levels of cytokines, chemokines and growth and differentiation factors, assessed in the previous study of Beumer <i>et al</i>. and in the current study [7].

<p>Patterns of expression levels of cytokines, chemokines and growth and differentiation factors, assessed in the previous study of Beumer <i>et al</i>. and in the current study [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153892#pone.0153892.ref007" target="_blank">7</a>].</p

Comparison of growth and differentiation factors between healthy controls and subjects.

<p>Comparison of growth and differentiation factors between healthy controls and subjects.</p

Serum levels of growth and differentiation factors in healthy controls (C), Seroconverting (SC) and Non-Seroconverting (NSC) family members.

<p>Serum levels of growth and differentiation factors in healthy controls (C), Seroconverting (SC) and Non-Seroconverting (NSC) family members.</p

Associations between selenium status and thyroid function tests.

<p>Associations between selenium status and thyroid function tests.</p

Baseline characteristics.

<p>Baseline characteristics.</p

Heat map showing the Cq values of all detectable MiRNAs (n = 135) in the different thyroid states.

<p>Clustering did not group the samples according to thyroid state.</p

Thyroid state in skeletal muscle of progeroid and naturally aged mice.

<p>T3 concentrations (A) and activities of D2 (B) and D3 (C) in muscle of 15-day-old WT and XAA (Csbm/m/Xpa-/-) mice (n = 3/group). T4 (D) and T3 (E) concentrations and activities of D2 (F) and D3 (G) in muscle of 18-week-old WT and MAA (Ercc1-/Δ-7) mice (n = 3/group). T4 (H) and T3 (I) concentrations and activities of D2 (J) and D3 (K) in muscle of 26-, 104-, and 130-week-old WT mice (n = 3-5/group). Values represent mean ± SE per group. * P < 0.05</p

Schematic representation of the survival response.

<p>Several types of stress (e.g. DNA damage and aging) can trigger a differential response in various tissues. This response ensures decreased TH signalling in liver and kidney, while it preserves TH signalling in brain, muscle and heart.</p

Thyroid state in brains of progeroid and naturally aged mice.

<p>Homogenates of whole brain or hemispheres were used. T4 (A) and T3 (B) concentrations in brains of 7-, 12-, 15-, and 18-day-old WT (squares) and XAA (Csbm/m/Xpa-/-) mice (n = 3/group). Activities of D2 (C) and D3 (D) brains of 7-, 12-, 15-, and 18-day-old WT and XAA (Csbm/m/Xpa-/-) mice (n = 3/group). T4 (E) and T3 (F) concentrations and D3 activity (G) in brains of 4-, and 18-week-old WT (black bars) and MAA (Ercc-/Δ-7) (white bars) mice (n = 3/group). It was not possible to measure D2 activity due to technical constraints. Values represent mean ± SE per group. * P < 0.05; ** P < 0.01; *** P < 0.001.</p