10 research outputs found
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): Occupational Health and Safety Aspects
Erste Anwendungen der Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) am Menschen
Klinische Ergebnisse der IntraPeritonealen Druck-Aerosolchemotherapie (PIPAC) bei Patienten mit Magenkarzinom und fortgeschrittener Peritonealkarzinose
IntraPeritoneale Druck-AerosolChemotherapie (PIPAC) mit Oxaliplatin beim kolorektalen Karzinom mit fortgeschrittener Peritonealkarzinose
Wirksamkeit der intraperitonealen Druck-Aerosolchemotherapie (PIPAC) mit Cisplatin und Doxorubicin bei rezidivierendem, Platin-resistenten Ovarialkarzinom: Preliminäre klinische Ergebnisse
Comparison of Tissue and Blood Concentrations of Oxaliplatin Administrated by Different Modalities of Intraperitoneal Chemotherapy
Pressurized Intra Peritoneal Aerosol Chemotherapy in patients suffering from peritoneal carcinomatosis of pancreatic adenocarcinoma
Patients suffering from peritoneal carcinomatosis of pancreatic adenocarcinoma were treated with Pressurized Intra Peritoneal Aerosol Chemotherapy (PIPAC), initial clinical findings are presented.Single institution, tertiary referral center certified for therapy of peritoneal disease. Prospective data collection of PIPAC therapy with doxorubicin 1.5 mg/m2 and cisplatin 7.5 mg/m2 of body surface delivered at intervals of six weeks. The outcome criteria were microscopic pathological response, survival and adverse events (v4.0 CTCAE).A total of 20 patients (m/f = 3:1) with a mean age of 64.9 (range: 45.0 to 87.0) years underwent 41 PIPAC procedures without intraoperative complications. The mean number of PIPAC cycles was 2.1 (range: one to four). Ten patients with ≥ 2 PIPAC applications were eligible for histological analysis to assess carcinoma regression. Complete or high grade tumor regression was found in two (10%) and five (25%) patients, respectively. An overall median survival of 36.6 weeks after the first PIPAC application was observed. One patient died postoperatively due to small bowel obstruction. No CTCAE level 3 and 4 complications occurred.In about one third of patients, repeated PIPAC therapy did induce histological regression of systemic chemo-resistant PC of pancreatic adenocarcinoma. Prospective randomized trials are needed to further clarify any clinical impact of such observations