Integrative Approach - New Level Knowledge of Functions: Opportunities and Prospects

In this article, the example of the mechanisms of heart rhythmogenesis in the intact organism is used to demonstrate the new capabilities provided by an integrative approach. It is shown that the rhythm is formed in the brain, transmitted to the heart in the form of signals along the vagus nerves and reproduces the heart. Evidence: the heart rhythm reproduces the natural efferent signals in the vagus nerves in the cardio-respiratory synchronism and in the intact organism sino-atrial node performs the functions of the latent pacemaker. Integration of the two hierarchical levels of rhythmogenesis (brain and intracardiac) provides the reliability and functional perfection of cardiac rhythm generation in the body. It is expedient to extend the presented methodology for scientific analysis to other organism systems

Parametric Generation of Second Sound by First Sound in Superfluid Helium

We report the first experimental observation of parametric generation of second sound (SS) by first sound (FS) in superfluid helium in a narrow temperature range in the vicinity of $T_\lambda$. The temperature dependence of the threshold FS amplitude is found to be in a good quantitative agreement with the theory suggested long time ago and corrected for a finite geometry. Strong amplitude fluctuations and two types of the SS spectra are observed above the bifurcation. The latter effect is quantitatively explained by the discreteness of the wave vector space and the strong temperature dependence of the SS dissipation length.Comment: 4 pages, 4 postscript figures, REVTE

The anti-aggregation activity of new 11-amino acid of erythropoietin derivate containing tripeptide motifs

Objective. To study the platelet antiaggregant activity of new 11-amino acid derivatives of erythropoietin, containing tripeptide motifs. Materials and methods. The platelet aggregation degree was determined using the platelet-rich plasma of male Wistar rats. Formation of platelet aggregates results in an increase in light transmission through the sample; the kinetics of the responses and maximal aggregation provide a quantitative assessment of platelet aggregation The degree of platelet aggregation is estimated by the magnitude of the amplitude of aggregatograms, and the time of onset of light transmission level as well the time of onset of 85% of light transmission. Results. When blood was incubated with the studied peptides P-αB1, P-αB3, and P-αB4, a pronounced antiplatelet effect was observed. This is evidenced by a decrease in the maximum light transmittance of the plasma to 28.4±1.00%, 29.7±1.13% and 30.1±0.97%, respectively, and a delay in its onset to 134.4±2,90, 135.8±3.72 and 132.0 ± 3.59 seconds, respectively. In this case, a shift in the plasma light transmission curve to the right was observed which characterizes the platelet aggregation process.   Conclusion. The addition of P-αB1, P-αB3, and P-αB4 produces antiplatelet activity, which is reflected by the shifting to the right of the platelet aggregation curve. The data obtained indicate a prolongation of platelet aggregation time and a decrease in its degre