41 research outputs found
Development and characterization of surface solid dispersion of curcumin for solubility enhancement
Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.  
Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride
The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug
Solubility enhancement of biperidine HCl by complexation with hydroxypropyl β-cyclodextrin
Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl
Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS
The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system
Design and in vitro evaluation of mouth dissolving tablets olanzapine
The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets. The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactor
Schedule of Factors Influencing Adherence (SOFIA) to Psychiatric Treatment in Persons with Schizophrenia: Validity and Pilot Testing
Qualitative research has highlighted the complex interplay of multiple factors that preclude persons with schizophrenia in rural Indian settings for discontinued psychiatric treatment. In this context, this paper aims to establish the face and content validities of an interview schedule titled „Schedule of Factors Influencing Adherence (SOFIA) to Psychiatric Treatment in Persons with Schizophrenia‟ which comprehensively assesses factors for discontinued psychiatric treatment and the feasibility of its administration of the schedule. SOFIA contains 16 factors. This schedule involves three phases of interviewing patients and family members. This was given to twelve experts who used likert scales to rate each items wells as the dimensions of the schedule. Later on, fifteen persons with schizophrenia were interviewed with SOFIA to test the feasibility of administration. The results showed that Fourteen items were rated as either satisfactory (score=4) or very much satisfactory (score=5) by all twelve experts; remaining two were rated as 4 or 5 by 11 experts. Regarding comprehensiveness of the factors, scoring methods and general instructions given to the interviewers, all provided scores > 4; regarding method of interviewing, 11 provided score of > 4; with regard to overall interview schedule, all experts provided scores > 4. Pilot testing revealed that it took 60 minutes to administer SOFIA
Schedule of Factors Influencing Adherence (SOFIA) to Psychiatric Treatment in Persons with Schizophrenia: Validity and Pilot Testing
Qualitative research has highlighted the complexinterplay of multiple factors that preclude persons withschizophrenia in rural Indian settings for discontinuedpsychiatric treatment. In this context, this paper aims toestablish the face and content validities of an interviewschedule titled „Schedule of Factors InfluencingAdherence (SOFIA) to Psychiatric Treatment in Personswith Schizophrenia‟ which comprehensively assessesfactors for discontinued psychiatric treatment and thefeasibility of its administration of the schedule. SOFIAcontains 16 factors. This schedule involves three phases of interviewing patients and family members. This wasgiven to twelve experts who used likert scales to rate eachitems wells as the dimensions of the schedule. Later on,fifteen persons with schizophrenia were interviewed withSOFIA to test the feasibility of administration. The resultsshowed that Fourteen items were rated as eithersatisfactory (score=4) or very much satisfactory (score=5)by all twelve experts; remaining two were rated as 4 or 5by 11 experts. Regarding comprehensiveness of thefactors, scoring methods and general instructions given tothe interviewers, all provided scores > 4; regardingmethod of interviewing, 11 provided score of > 4; withregard to overall interview schedule, all experts providedscores > 4. Pilot testing revealed that it took 60 minutes to administer SOFIA