A simple theory of protein folding kinetics

We present a simple model of protein folding dynamics that captures key qualitative elements recently seen in all-atom simulations. The goals of this theory are to serve as a simple formalism for gaining deeper insight into the physical properties seen in detailed simulations as well as to serve as a model to easily compare why these simulations suggest a different kinetic mechanism than previous simple models. Specifically, we find that non-native contacts play a key role in determining the mechanism, which can shift dramatically as the energetic strength of non-native interactions is changed. For protein-like non-native interactions, our model finds that the native state is a kinetic hub, connecting the strength of relevant interactions directly to the nature of folding kinetics

From open resources to educational opportunity

Since MIT’s bold announcement of the OpenCourseWare initiative in 2001, the content of over 700 of its courses have been published on the Web and made available for free to the world. Important infrastructure initiatives have also been launched recently with a view to enabling the sustainable implementation of these educational programmes, through strengthening organizational capacity as well as through building open, standards‐based technology. Each of these initiatives point to a rich palette of transformational possibilities for education; together with the growing open source movement, they offer glimpses of a sustainable ecology of substantial and quality educational resources. This discussion piece will highlight some of the educational opportunity presented by MIT’s current information technology‐enabled educational agenda and related initiatives, along with their strategic underpinnings and implications. It will address various dimensions of their impact on the form and function of education. It will examine how these ambitious programmes achieve a vision characterized by an abundance of sustainable, transformative educational opportunities, not merely pervasive technology

Epidermoid Cyst of Spleen

Splenic cysts are very rare lesions, most of them being parasitic systs. Nonparasitic cysts are uncommon. We report a case of young female who presented with mass and pain abdomen. Ultrasound examination revealed splenic syst. The diagnosis of epidermoid cyst was made based on characteristic lining on histopathological examinatio

Total Minimal Dominating Signed Graph

Cartwright and Harary considered graphs in which vertices represent persons and the edges represent symmetric dyadic relations amongst persons each of which designated as being positive or negative according to whether the nature of the relationship is positive (friendly, like, etc.) or negative (hostile, dislike, etc.). Such a network S is called a signed graph. Signed graphs are much studied in literature because of their extensive use in modeling a variety socio-psychological process and also because of their interesting connections with many classical mathematical systems

The planar algebra of a semisimple and cosemisimple Hopf algebra

To a semisimple and cosemisimple Hopf algebra over an algebraically closed field, we associate a planar algebra defined by generators and relations and show that it is a connected, irreducible, spherical, non-degenerate planar algebra with non-zero modulus and of depth two. This association is shown to yield a bijection between (the isomorphism classes, on both sides, of) such objects.Comment: 16 pages, 20 figures; content adde

Guionnet-Jones-Shlyakhtenko subfactors associated to finite-dimensional Kac algebras

We analyse the Guionnet-Jones-Shlyakhtenko construction for the planar algebra associated to a finite-dimensional Kac algebra and identify the factors that arise as finite interpolated free group factors.Comment: 18 pages, 21 figures, corrected typo