The Mars Desert Research Station - ERAU Crew 160 Expedition

The Mars Desert Research Station (MDRS) is a research program which is owned and operated by the Mars Society. The MDRS is located in Hanksville, Utah which hosts simulations that are typically two weeks long for professional scientists and engineers as well as college students of all levels, in training for human operations specifically on Mars. This space analog facility is in isolation, allowing for rigorous field studies regarding research that represents a true mission as if the crew members are conducting a real expedition on Mars. Participants are assigned specific roles and tasks that are typically aligned with their research topics as well as their educational backgrounds. Six students were selected from Embry-Riddle Aeronautical University to attend in December of 2015. Two main studies were conducted at the station which included memory tracking in isolated environments and the monitoring of solar radiation levels with the corresponding consequences on personality/characteristic traits. The results showed that the isolated environment as well as social factors may have attributed to the data obtained, including induced stress that may have occurred from daily tasks

Simulation on Mars - Mars Desert Research Station ERAU Crew 160 Rotation

The Mars Desert Research Station (MDRS) is a research program which is owned and operated by the Mars Society. MDRS is a space analog facility located in Hanksville, Utah that hosts field seasons that are two weeks long where professional scientists as well as undergraduate students may attend. The relative isolation of the facility allowed for rigorous field studies for research in a two week simulation that acts as if the crew members are conducting a real expedition on Mars. Participants are assigned specific roles and tasks that are typically aligned with their research topics as well as their educational backgrounds. Six students were selected from Embry-Riddle Aeronautical University to attend in December of 2015. Two main studies were conducted at the station which included memory tracking in isolated environments which included survey questions as well as timed puzzles to observe any consequences, and monitoring solar radiation levels and the corresponding consequences on personality/characteristic

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Polygenic risk scores for autoimmune related diseases are significantly different in cancer exceptional responders

Abstract A small number of cancer patients respond exceptionally well to therapies and survive significantly longer than patients with similar diagnoses. Profiling the germline genetic backgrounds of exceptional responder (ER) patients, with extreme survival times, can yield insights into the germline polymorphisms that influence response to therapy. As ERs showed a high incidence in autoimmune diseases, we hypothesized the differences in autoimmune disease risk could reflect the immune background of ERs and contribute to better cancer treatment responses. We analyzed the germline variants of 51 ERs using polygenic risk score (PRS) analysis. Compared to typical cancer patients, the ERs had significantly elevated PRSs for several autoimmune-related diseases: type 1 diabetes, hypothyroidism, and psoriasis. This indicates that an increased genetic predisposition towards these autoimmune diseases is more prevalent among the ERs. In contrast, ERs had significantly lower PRSs for developing inflammatory bowel disease. The left-skew of type 1 diabetes score was significant for exceptional responders. Variants on genes involved in the T1D PRS model associated with cancer drug response are more likely to co-occur with other variants among ERs. In conclusion, ERs exhibited different risks for autoimmune diseases compared to typical cancer patients, which suggests that changes in a patient’s immune set point or immune surveillance specificity could be a potential mechanistic link to their exceptional response. These findings expand upon previous research on immune checkpoint inhibitor-treated patients to include those who received chemotherapy or radiotherapy

SEIS: Insight’s Seismic Experiment for Internal Structure of Mars

By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars’ surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking’s Mars seismic monitoring by a factor of ∼2500 at 1 Hz and ∼200000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars’ surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of ∼3 at 40∘ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution