Quantum Corrections to the Gravitational Potential and Orbital Motion

GRT predicts the existence of relativistic corrections to the static Newtonian potential, which can be calculated and verified experimentally. The idea leading to quantum corrections at large distances consists of the interactions of massless particles, which only involve their coupling energies at low energies. Using the quantum correction term of the potential we obtain the perturbing quantum acceleration function. Next, with the help of the Newton-Euler planetary equations, we calculate the time rates of changes of the orbital elements per revolution for three different orbits around the primary. For one solar mass primary and an orbit with semimajor axis and eccentricity equal to that of Mercury we obtain that Δωqu = 1.517x10–81 °/cy, while ΔMqu = –1.840x10–46 rev/cy

Quantum Corrections to the Gravitational Potential and Orbital Motion

GRT predicts the existence of relativistic corrections to the static Newtonian potential, which can be calculated and verified experimentally. The idea leading to quantum corrections at large distances consists of the interactions of massless particles, which only involve their coupling energies at low energies. Using the quantum correction term of the potential we obtain the perturbing quantum acceleration function. Next, with the help of the Newton-Euler planetary equations, we calculate the time rates of changes of the orbital elements per revolution for three different orbits around the primary. For one solar mass primary and an orbit with semimajor axis and eccentricity equal to that of Mercury we obtain that Δωqu = 1.517x10–81 °/cy, while ΔMqu = –1.840x10–46 rev/cy

Realistic Simulation of Local Solar Supergranulation

I represent results three-dimensional numerical simulation of solar surface convection on scales local supergranulation with realistic model physics. I study thermal structure of convective motions in photosphere, the range of convection cell sizes and the penetration depths of convection. A portion of the solar photosphere extending 100 x 100 Mm horizontally and from 0 Mm down to 20 Mm below the visible surface is considered. I take equation of state and opacities of stellar matter and distribution with radius of all physical variables from Solar Standard Model. The equations of fully compressible radiation hydrodynamics with dynamical viscosity and gravity are solved. The high order conservative PPML difference scheme for the hydrodynamics, the method of characteristic for the radiative transfer and dynamical viscosity from subgrid scale modeling are applied. The simulations are conducted on a uniform horizontal grid of 1000 x 1000, with 168 nonuniformly spaced vertical grid points, on 256 processors with distributed memory multiprocessors on supercomputer MVS5000 in Computational Centre of Russian Academy of Sciences.Comment: 4 pages, 3 figures. To appear in AIP Conference Proceedings, "Exploring the Solar System and the Universe", Apr 8-12 2008, Bucharest, Romania, eds. Vasile Mioc, Cristiana Dumitrache & Nedelia A. Popesc

Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer

Colon cancer is a widespread pathology with complex biochemical etiology based on a significant number of intracellular signaling pathways that play important roles in carcinogenesis, tumor proliferation and metastasis. These pathways function due to the action of key enzymes that can be used as targets for new anticancer drug development. Herein we report the synthesis and biological antiproliferative evaluation of a series of novel S-substituted 1H-3-R-5-mercapto-1,2,4-triazoles, on a colorectal cancer cell line, HT-29. Synthesized compounds were designed by docking based virtual screening (DBVS) of a previous constructed compound library against protein targets, known for their important role in colorectal cancer signaling: MEK1, ERK2, PDK1, VEGFR2. Among all synthesized structures, TZ55.7, which was retained as a possible PDK1 (phospholipid-dependent kinase 1) inhibitor, exhibited the most significant cytotoxic activity against HT-29 tumor cell line. The same compound alongside other two, TZ53.7 and TZ3a.7, led to a significant cell cycle arrest in both sub G0/G1 and G0/G1 phase. This study provides future perspectives for the development of new agents containing the 1,2,4-mercapto triazole scaffold with antiproliferative activities in colorectal cancer