4 research outputs found
Crossover and mutation operators for genetic algorithm with permutation representation of solution domain
Shorten new product development and introduction in bio(pharmaceutical) industries
Introduction Nowadays, the production of monoclonal antibody using animal cell culture (MAB) requires new improvements. The approach presented in this poster is based on simulation, scheduling optimization and de-bottlenecking of production processes. Mainly an abstraction of the P&I D (Process and instrumentation diagram) is done and the control software for a Biotech Plan is modeled. The modeling of the control software is based on ISA standards: ISA-88 and ISA-95. These standards are crucial for optimization and debottlenecking of processes. The simulation of a small scale production facilitates to recognize lowlights and highlights in the production , improving the results when it is applied to a full scale production