Comparison of dynamic of autonomic control indices in cardiovascular system under the treatment by ACE inhibitor (Enalapril) and beta-blocker (Metoprolol) in patients with hypertension

The objective of the present research was to compare the influence of Enalapril and Metoprolol on synchronization of 0.1 Hz-regulation of heart and blood microcirculation. 42 patients aged 49±9 years old with hypertension I, II were included in the study. 0.1 Hz-oscillations in heart rate variability (HRV) and blood microcirculation were registered during the passive orthostatic sign while breathing spontaneously. The duration of each test was 10 minutes. Synchronization was estimated as a phase difference between 0.1 Hz-rhythms in heart rate and in filling of blood microcirculation. Quantitative measures of synchronization were also estimated. In addition frequency values of HRV spectrum in LF- and HF-ranges were assessed. Enalapril and Metoprolol had comparable effect on blood pressure reduction. Treatment with both Enalapril and Metoprolol in patients with significant vegetative dysfunction resulted in repair of functional interaction between 0.1 Hz-regulation of heart and blood microcirculation. Enalapril was preferred in hypertensive patients with prevalence of disorders of vegetative regulation of blood microcirculation. Metoprolol influenced positively on 0,1 Hz-rhythm synchronization in patients with predominance of heart vegetative regulation dysfunction and in patients with sympathicotonia. In patients with hypertension and initially normal level of synchronization of 0.1 Hz-mechanisms treatment with Enalapril or Metoprolol caused functional dissociation. Differentiated approach to the choice of hypertensive therapy should consider individual peculiarities of system vegetative dysfunction. The level of synchronization of 0.1 Hz-rhythms in cardiovascular system should especially be evaluated initially and during the treatmen

Properties of Fe, Ni and Zn isotope chains near the drip-line

The location of proton and neutron drip-lines and the characteristics of the neutron-deficient and the neutron-rich isotopes Fe, Ni and Zn on the basis of Hartree-Fock method with Skyrme forces (Ska, SkM*, Sly4) taking into account deformation was investigated. The calculations predict a big jump of deformation parameter up to β ~ 0.4 for Ni isotopes in the neighborhood of N ~ 62. The manifestation of magic numbers for isotopes ⁴⁸Ni, ⁵⁶Ni, ⁷⁸Ni and also for the stable isotope in the respect to neutron emission ¹¹⁰Ni which is situated beyond the neutron drip-line is discussed.На основі метода Хартрі-Фока з силами Скірма (Ska, SkM*, Sly4) при врахуванні деформації досліджено положення протонної і нейтронної границі стабільності і характеристики нейтронодефіцітних і нейтрононадлишкових изотопів Fe, Ni и Zn. Розрахунки зазбачають, що для изотопів Ni в околі N ~ 62 спостерігається великий стрибок величини параметра деформації до β ~ 0.4. Обговорюються прояви магічних чисел для изотопів нікеля ⁴⁸Ni, ⁵⁶Ni, ⁷⁸Ni, а також для нейтроностабільного изотопа ¹¹⁰Ni , який знаходиться за межами границі стабильності.На основе метода Хартри-Фока с силами Скирма (Ska, SkM*, Sly4) при учете деформации исследовано положение протонной и нейтронной границы стабильности и характеристики нейтронодефицитных и нейтроноизбыточных изотопов Fe, Ni и Zn. Расчеты предсказывают, что для изотопов Ni в окрестности N ~ 62 наблюдается большой скачок величины параметра деформации до β ~ 0.4. Обсуждается проявление магических чисел для изотопов никеля ⁴⁸Ni, ⁵⁶Ni, ⁷⁸Ni, а также для нейтроностабильного изотопа ¹¹⁰Ni, который находится за пределами границы стабильности

Oscillatory processes in vegetative regulation of cardiovascular system (Review)

The research work provides current understanding of the functional organization of vegetative regulation of cardiovascular system. The basic oscillatory processes in vegetative regulation system have been determined, and the information about their functional properties has been generalized. The most significant oscillatory processes are main heart rhythm, respiration and low-frequency oscillations in vegetative regulation of cardiovascular system. The article considers intersystem interactions involving the vegetative regulation of cardiovascular syste