Somatostatin agonist pasireotide inhibits exercise stimulated growth in the male Siberian hamster (Phodopus sungorus)

R.Dumbell was supported by a University of Aberdeen PhD studentship and a research visit grant awarded by the British Society of Neuroendocrinology. Further support was provided by the Scottish Government Rural and Environment Science and Analytical Services Division (Barrett and the German Research Foundation (DFG; STE 331/8-1; Steinlechner lab). We are grateful for technical assistance from Dana Wilson at RINH and Siegried Hiliken at UVMH, and thank Dr Claus-Dieter Mayer of Biomathematics & Statistics Scotland for valuable advice on statistical analysis.Peer reviewedPostprin

Readiness of Quantum Optimization Machines for Industrial Applications

There have been multiple attempts to demonstrate that quantum annealing and, in particular, quantum annealing on quantum annealing machines, has the potential to outperform current classical optimization algorithms implemented on CMOS technologies. The benchmarking of these devices has been controversial. Initially, random spin-glass problems were used, however, these were quickly shown to be not well suited to detect any quantum speedup. Subsequently, benchmarking shifted to carefully crafted synthetic problems designed to highlight the quantum nature of the hardware while (often) ensuring that classical optimization techniques do not perform well on them. Even worse, to date a true sign of improved scaling with the number of problem variables remains elusive when compared to classical optimization techniques. Here, we analyze the readiness of quantum annealing machines for real-world application problems. These are typically not random and have an underlying structure that is hard to capture in synthetic benchmarks, thus posing unexpected challenges for optimization techniques, both classical and quantum alike. We present a comprehensive computational scaling analysis of fault diagnosis in digital circuits, considering architectures beyond D-wave quantum annealers. We find that the instances generated from real data in multiplier circuits are harder than other representative random spin-glass benchmarks with a comparable number of variables. Although our results show that transverse-field quantum annealing is outperformed by state-of-the-art classical optimization algorithms, these benchmark instances are hard and small in the size of the input, therefore representing the first industrial application ideally suited for testing near-term quantum annealers and other quantum algorithmic strategies for optimization problems.Comment: 22 pages, 12 figures. Content updated according to Phys. Rev. Applied versio

Stroboscopic Laser Diagnostics for Detection of Ordering in One-Dimensional Ion beam

A novel diagnostic method for detecting ordering in one-dimensional ion beams is presented. The ions are excited by a pulsed laser at two different positions along the beam and fluorescence is observed by a group of four photomultipliers. Correlation in fluorescence signals is firm indication that the ion beam has an ordered structure.Comment: 7 pages, REVTEX, fig3 uuencoded, figs 1-2 available upon request from [email protected], to appear in Phys. Rev.

The Effect of absorbing sites on the one-dimensional cellular automaton traffic flow with open boundaries

The effect of the absorbing sites with an absorbing rate $\beta_{0}$, in both one absorbing site (one way out) and two absorbing sites (two ways out) in a road, on the traffic flow phase transition is investigated using numerical simulations in the one-dimensional cellular automaton traffic flow model with open boundaries using parallel dynamics.In the case of one way out, there exist a critical position of the way out $i_{c1}$ below which the current is constant for $\beta_{0}$$<$$\beta_{0c2}$ and decreases when increasing $\beta_{0}$ for $\beta_{0}$$>$$\beta_{0c2}$. When the way out is located at a position greater than $i_{c2}$, the current increases with $\beta_{0}$ for $\beta_{0}$$<$$\beta_{0c1}$ and becomes constant for any value of $\beta_{0}$ greater than $\beta_{0c1}$. While, when the way out is located at any position between $i_{c1}$ and $i_{c2}$ ($i_{c1}$$<$$i_{c2}$), the current increases, for $\beta_{0}$$<$$\beta_{0c1}$, with $\beta_{0}$ and becomes constant for $\beta_{0c1}$$<$$\beta_{0}$$<$$\beta_{0c2}$ and decreases with $\beta_{0}$ for $\beta_{0}$$>$$\beta_{0c2}$. In the later case the density undergoes two successive first order transitions; from high density to maximal current phase at $\beta_{0}$$=$$\beta_{0c1}$ and from intermediate density to the low one at $\beta_{0}$$=$$\beta_{0c2}$. In the case of two ways out located respectively at the positions $i_{1}$ and $i_{2}$, the two successive transitions occur only when the distance $i_{2}$-$i_{1}$ separating the two ways is smaller than a critical distance $d_{c}$. Phase diagrams in the ($\alpha,\beta_{0}$), ($\beta,\beta_{0}$) and ($i_{1},\beta_{0}$) planes are established. It is found that the transitions between Free traffic, Congested traffic and maximal current phase are first order

Analytic results for NN particles with 1/r21/r^2 interaction in two dimensions and an external magnetic field

The $2N$-dimensional quantum problem of $N$ particles (e.g. electrons) with interaction $\beta/r^2$ in a two-dimensional parabolic potential $\omega_0$ (e.g. quantum dot) and magnetic field $B$, reduces exactly to solving a $(2N-4)$-dimensional problem which is independent of $B$ and $\omega_0$. An exact, infinite set of relative mode excitations are obtained for any $N$. The $N=3$ problem reduces to that of a ficticious particle in a two-dimensional, non-linear potential of strength $\beta$, subject to a ficticious magnetic field $B_{\rm fic}\propto J$, the relative angular momentum.Comment: To appear in Physical Review Letters (in press). RevTeX file. Two figures available from [email protected] or [email protected]

The theory of heating of the quantum ground state of trapped ions

Using a displacement operator formalism, I analyse the depopulation of the vibrational ground state of trapped ions. Two heating times, one characterizing short time behaviour, the other long time behaviour are found. The short time behaviour is analyzed both for single and multiple ions, and a formula for the relative heating rates of different modes is derived. The possibility of correction of heating via the quantum Zeno effect, and the exploitation of the suppression of heating of higher modes to reduce errors in quantum computation is considered.Comment: 9 pages, 2 figure

Laser Cooling of two trapped ions: Sideband cooling beyond the Lamb-Dicke limit

We study laser cooling of two ions that are trapped in a harmonic potential and interact by Coulomb repulsion. Sideband cooling in the Lamb-Dicke regime is shown to work analogously to sideband cooling of a single ion. Outside the Lamb-Dicke regime, the incommensurable frequencies of the two vibrational modes result in a quasi-continuous energy spectrum that significantly alters the cooling dynamics. The cooling time decreases nonlinearly with the linewidth of the cooling transition, and the effect of trapping states which may slow down the cooling is considerably reduced. We show that cooling to the ground state is possible also outside the Lamb-Dicke regime. We develop the model and use Quantum Monte Carlo calculations for specific examples. We show that a rate equation treatment is a good approximation in all cases.Comment: 13 pages, 10 figure

Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes

Mice overexpressing human alpha-synuclein in oligodendrocytes (MBP1-alpha-syn) recapitulate some key functional and neuropathological features of multiple system atrophy (MSA). Whether or not these mice develop severe autonomic failure, which is a key feature of human MSA, remains unknown. We explored cardiovascular autonomic regulation using long-term blood pressure (BP) radiotelemetry and pharmacological testing. We instrumented 12 MBP1-alpha-syn mice and 11 wild-type mice aged 9 months for radiotelemetry. Animals were tested with atropine, metoprolol, clonidine, and trimethaphan at 9 and 12 months age. We applied spectral and cross-spectral analysis to assess heart rate (HR) and BP variability. At 9 months of age daytime BP (transgenic: 101 +/- 2 vs. wild type: 99 +/- 2 mmHg) and HR (497 +/- 11 vs. 505 +/- 16 beats/min) were similar. Circadian BP and HR rhythms were maintained. Nighttime BP (109 +/- 2 vs. 108 +/- 2 mmHg) and HR (575 +/- 15 vs. 569 +/- 14 beats/min), mean arterial BP responses to trimethaphan (-21 +/- 8 vs. -10 +/- 5 mmHg, P = 0.240) and to clonidine (-8 +/- 3 vs. -5 +/- 2 mmHg, P = 0.314) were similar. HR responses to atropine (+159 +/- 24 vs. +146 +/- 22 beats/min), and to clonidine (-188 +/- 21 vs. -163 +/- 33 beats/min) did not differ between strains. Baroreflex sensitivity (4 +/- 1 vs. 4 +/- 1 msec/mmHg) and HR variability (total power, 84 +/- 17 vs. 65 +/- 21 msec(2)) were similar under resting conditions and during pharmacological testing. Repeated measurements at 12 months of age provided similar results. In mice, moderate overexpression of human alpha-synuclein in oligodendrocytes is not sufficient to induce overt autonomic failure. Additional mechanisms may be required to express the autonomic failure phenotype including higher levels of expression or more advanced age

Photon Statistics; Nonlinear Spectroscopy of Single Quantum Systems

A unified description of multitime correlation functions, nonlinear response functions, and quantum measurements is developed using a common generating function which allows a direct comparison of their information content. A general formal expression for photon counting statistics from single quantum objects is derived in terms of Liouville space correlation functions of the material system by making a single assumption that spontaneous emission is described by a master equation

Transition Between Ground State and Metastable States in Classical 2D Atoms

Structural and static properties of a classical two-dimensional (2D) system consisting of a finite number of charged particles which are laterally confined by a parabolic potential are investigated by Monte Carlo (MC) simulations and the Newton optimization technique. This system is the classical analog of the well-known quantum dot problem. The energies and configurations of the ground and all metastable states are obtained. In order to investigate the barriers and the transitions between the ground and all metastable states we first locate the saddle points between them, then by walking downhill from the saddle point to the different minima, we find the path in configurational space from the ground state to the metastable states, from which the geometric properties of the energy landscape are obtained. The sensitivity of the ground-state configuration on the functional form of the inter-particle interaction and on the confinement potential is also investigated