A study on Stereoencephalotomy for Involuntary Movement

1) A head fixing apparatus radiography was made. Encephalograph could be taken in correct position to measure exactly the position of the pallidum. 2) A characteristic stereoenchephalotomic apparatus was made and the results were found satisfactory in using. 3) 10% Moljodol oil-wax injected to clarify the position and the form of the lesion after operation. 4) After operation radiorgaphy was performed to make the form and the position of the lesion clear. They were compared with the operation effects

A QM/MM study of nitric oxide reductase-catalysed N₂O formation

<div><p>Nitrous oxide (N₂O), with a greenhouse effect 300 times that of CO₂, is increasingly eliminated into the atmosphere. Using a hybrid quantum mechanics/molecular mechanics (QM/MM) method, we examined nitric oxide reductase-catalysed N₂O formation, which includes two important chemical reactions of N–N bond formation and N–O bond cleavage. The N–N bond formation has no activation barrier, but N–O bond cleavage exhibits an activation barrier of 20.9 kcal·mol⁻¹ at the QM/MM level. We show that the N–O bond cleavage occurs via a hyponitrous intermediate (Fe_B (II; <i>s</i> = 4/2)/N₂O₂ (−1; <i>s</i> = 1/2)/ (III; <i>s</i> = −1/2)), with bidentate coordination between Glu211 and a non-heme iron atom. The Glu211 coordination decreases the N–O bond cleavage energy barrier by inhibiting the formation of stable, five-membered ring intermediate (Fe_B–O¹–N¹–N²–O²–).</p></div