1 research outputs found
Development of a Potent and Selective HDAC8 Inhibitor
A novel,
isoform-selective inhibitor of histone deacetylase 8 (HDAC8)
has been discovered by the repurposing of a diverse compound collection.
Medicinal chemistry optimization led to the identification of a highly
potent (0.8 nM) and selective inhibitor of HDAC8