Anomalous origin of the left coronary artery with origin in the right coronary artery from a single coronary ostium associated with multivessel coronary artery disease: case report and literature review

The anomalous origin of the coronary arteries is a group of rare congenital heart conditions in which there has been an increase in its diagnosis thanks to more accessible and less invasive imaging techniques such as coronary angiotomography, which allows visualization of the arteries in its entire path in a short exploration interval, with adequate spatial and temporal resolution. The clinical presentation is variable, up to 80% are asymptomatic and the remaining 20% may present arrhythmias, myocardial infarction, heart failure and sudden death. We present the case of a patient with unstable angina in whom an anomalous origin of the left coronary artery (LCA) with origin in the right coronary artery (RCA) from a single coronary ostium associated with multivessel coronary artery disease was diagnosed

Green biomass production and quality of essential oils of pal-marosa (cymbopogon martini (roxb.) will. watson) with appli-cation of synthesis fertilizers and organic fertilizers

El uso de fertilizantes minerales en cultivos de Cymbopogon martini (Palmarosa) con el fin de incrementar la biomasa y el rendimiento de aceite esencial (AE) es una práctica cada vez más frecuente. Este aceite es rico en geraniol y acetato de geranilo, moléculas con alto valor en las industrias de productos cosméticos y farmacéutica. Las plantas fueron obtenidas del Centro Nacional de Investigación Agroindustrial de Plan-tas Aromaticas y Medicinales de la Universidad Industrial de Santander (UIS) (Cenivam) (07° 08’ 31.68”N, 73° 07’ 06.14O; 988 m.s.n.m.), Santander, Colombia. El objetivo del estudio fue evaluar la productividad de biomasa y analizar la calidad y el rendimiento de los aceites esenciales (AE) de este cultivo con la apli-cación de tres tipos de fertilizantes químico: Nutrimon® 14-14-14, NPK granulado (10% N, 14% P2O5 , 14% K2O), en dosis de 2, 4 y 6 g/planta, más un tratamiento con 400 g de un fertilizante orgánico,. Se utilizó un diseño de bloques completos al azar, con trece tratamientos y tres cosechas de tres plantas cada una como repeticiones. Los datos fueron sometidos a análisis de variancia con comparación de las medias por la prueba de Tukey a 5% de probabilidad. No se observaron correlaciones entre biomasa y rendimien-to del AE en función del tipo del fertilizante aplicado, lo que sugirió que los tratamientos que incrementa-ron la producción de biomasa no necesariamente representaron mayor rendimiento del AE y viceversa. Se encontró que los fertilizantes orgánicos son ideales para este cultivo, ya que favorecieron rendimientos relativamente altos en aceite, con altos porcentajes de geraniol y acetato de geranilo.The use of mineral fertilizers in Cymbopogon martini (Palmarosa) crops has been implemented in order to increase biomass and essential oil yield. Palmarosa oil is rich in geraniol and geranyl acetate, molecules with high value in the cosmetic and pharmaceutical industries. Plants were obtained from the Seed Bank of the Centro Nacional de Investigación Agroindustrial de Plantas Aromaticas y Medicinales de la Univer-sidad Industrial de Santander (UIS) (Cenivam), Santander, Colombia. Seedlings were maintained under conditions of nursery for two months and then were taken to the experimental field, in which the survival rate in the new crop conditions was calculated. The crop was carried out in the Cenivam experimental area (07° 08’ 31.68”N, 73° 07’ 06.14W; 988 m.a.s.l.), in a sandy-soil clay loam. The aim of the study was to evaluate the biomass productivity and analyze the quality and yield of the essential oil obtained of the C. martini crop under three types of fertilizers: Nutrimon® 14-14-14, mineral NPK granular fertilizer for agricultural use for land application composed of ammoniacal nitrogen 10%, nitric nitrogen (4%), assimi-lable phosphorus (P2O5) (14%), and water soluble potassium (K2O) (14%), for treatments, 2, 4 and 6 g/plant were applied locally; and a treatment with 400 g of organic fertilizer were applied. A complete random block design, with thirteen treatments and three harvests and each one, consisting of three plants as replications was used. Data were analyzed using analysis of variance, comparing the means by Tukey test at 5% probability. No correlations between biomass and essential oil yield, according to the type of fertilizer applied, were observed, that suggests that treatments that increased the biomass did not neces-sarily represent higher essential oil yield, and treatments whose essential oil yield increments were signifi-cant, not necessarily corresponded to the largest biomass. It was found that organic or green fertilizers could be ideal for these crops, as they allowed relatively high oil yields, with higher percentages of geraniol and its acetate

An updated synthesis of N1′‐([11C]methyl)naltrindole for positron emission tomography imaging of the delta opioid receptor

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/167550/1/jlcr3898.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167550/2/jlcr3898_am.pd

Producción de biomasa verde y calidad de aceites esenciales de palmarosa (Cymbopogon martini Roxb.) con aplicación de fertilizantes de síntesis y orgánicos

El uso de fertilizantes minerales en cultivos de Cymbopogon martini Roxb. (Palmarosa) con el fin de incrementar la biomasa y el rendimiento de aceite esencial (AE) es una práctica cada vez más frecuente. Este aceite es rico en geraniol y acetato de geranilo, moléculas con alto valor en las industrias de productos cosméticos y farmacéutica. Las plantas fueron obtenidas del Centro Nacional de Investigación Agroindustrial de Plantas Aromaticas y Medicinales de la Universidad Industrial de Santander (UIS) (Cenivam) (07° 08’ 31.68”N, 73° 07’ 06.14O; 988 m.s.n.m.), Santander, Colombia. El objetivo del estudio fue evaluar la productividad de biomasa y analizar la calidad y el rendimiento de los aceites esenciales (AE) de este cultivo con la aplicación de tres tipos de fertilizantes químico: Nutrimon® 14-14-14, NPK granulado (10% N, 14% P2O5 , 14% K2O), en dosis de 2, 4 y 6 g/planta, más un tratamiento con 400 g de un fertilizante orgánico,. Se utilizó un diseño de bloques completos al azar, con trece tratamientos y tres cosechas de tres plantas cada una como repeticiones. Los datos fueron sometidos a análisis de variancia con comparación de las medias por la prueba de Tukey a 5% de probabilidad. No se observaron correlaciones entre biomasa y rendimiento del AE en función del tipo del fertilizante aplicado, lo que sugirió que los tratamientos que incrementaron la producción de biomasa no necesariamente representaron mayor rendimiento del AE y viceversa. Se encontró que los fertilizantes orgánicos son ideales para este cultivo, ya que favorecieron rendimientos relativamente altos en aceite, con altos porcentajes de geraniol y acetato de geranilo.The use of mineral fertilizers in Cymbopogon martini Roxb. (Palmarosa) crops has been implemented in order to increase biomass and essential oil yield. Palmarosa oil is rich in geraniol and geranyl acetate, molecules with high value in the cosmetic and pharmaceutical industries. Plants were obtained from the Seed Bank of the Centro Nacional de Investigación Agroindustrial de Plantas Aromaticas y Medicinales de la Universidad Industrial de Santander (UIS) (Cenivam), Santander, Colombia. Seedlings were maintained under conditions of nursery for two months and then were taken to the experimental field, in which the survival rate in the new crop conditions was calculated. The crop was carried out in the Cenivam experimental area (07° 08’ 31.68”N, 73° 07’ 06.14W; 988 m.a.s.l.), in a sandy-soil clay loam. The aim of the study was to evaluate the biomass productivity and analyze the quality and yield of the essential oil obtained of the C. martini crop under three types of fertilizers: Nutrimon® 14-14-14, mineral NPK granular fertilizer for agricultural use for land application composed of ammoniacal nitrogen 10%, nitric nitrogen (4%), assimilable phosphorus (P2O5) (14%), and water soluble potassium (K2O) (14%), for treatments, 2, 4 and 6 g/plant were applied locally; and a treatment with 400 g of organic fertilizer were applied. A complete random block design, with thirteen treatments and three harvests and each one, consisting of three plants as replications was used. Data were analyzed using analysis of variance, comparing the means by Tukey test at 5% probability. No correlations between biomass and essential oil yield, according to the type of fertilizer applied, were observed, that suggests that treatments that increased the biomass did not necessarily represent higher essential oil yield, and treatments whose essential oil yield increments were significant, not necessarily corresponded to the largest biomass. It was found that organic or green fertilizers could be ideal for these crops, as they allowed relatively high oil yields, with higher percentages of geraniol and its acetate.Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias5507-543-31904Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombianan

Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC)

Abstract Background In the US, EU and elsewhere, basic clinical research studies with positron emission tomography (PET) radiotracers that are generally recognized as safe and effective (GRASE) can often be conducted under institutional approval. For example, in the United States, such research is conducted under the oversight of a Radioactive Drug Research Committee (RDRC) as long as certain requirements are met. Firstly, the research must be for basic science and cannot be intended for immediate therapeutic or diagnostic purposes, or to determine the safety and effectiveness of the PET radiotracer. Secondly, the PET radiotracer must be generally recognized as safe and effective. Specifically, the mass dose to be administered must not cause any clinically detectable pharmacological effect in humans, and the radiation dose to be administered must be the smallest dose practical to perform the study and not exceed regulatory dose limits within a 1-year period. In our experience, the main barrier to using a PET radiotracer under RDRC approval is accessing the required information about mass and radioactive dosing. Results The University of Michigan (UM) has a long history of using PET radiotracers in clinical research studies. Herein we provide dosing information for 55 radiotracers that will enable other PET Centers to use them under the approval of their own RDRC committees. Conclusions The data provided herein will streamline future RDRC approval, and facilitate further basic science investigation of 55 PET radiotracers that target functionally relevant biomarkers in high impact disease states.http://deepblue.lib.umich.edu/bitstream/2027.42/174047/1/41181_2020_Article_110.pd

Reduced dengue incidence following city-wide wMel Wolbachia mosquito releases throughout three Colombian cities: Interrupted time series analysis and a prospective case-control study.

BackgroundThe introduction of Wolbachia (wMel strain) into Aedes aegypti mosquitoes reduces their capacity to transmit dengue and other arboviruses. Randomised and non-randomised studies in multiple countries have shown significant reductions in dengue incidence following field releases of wMel-infected Ae. aegypti. We report the public health outcomes from phased, large-scale releases of wMel-Ae. aegypti mosquitoes throughout three contiguous cities in the Aburrá Valley, Colombia.Methodology/principal findingsFollowing pilot releases in 2015-2016, staged city-wide wMel-Ae. aegypti deployments were undertaken in the cities of Bello, Medellín and Itagüí (3.3 million people) between October 2016 and April 2022. The impact of the Wolbachia intervention on dengue incidence was evaluated in two parallel studies. A quasi-experimental study using interrupted time series analysis showed notified dengue case incidence was reduced by 95% in Bello and Medellín and 97% in Itagüí, following establishment of wMel at ≥60% prevalence, compared to the pre-intervention period and after adjusting for seasonal trends. A concurrent clinic-based case-control study with a test-negative design was unable to attain the target sample size of 63 enrolled virologically-confirmed dengue (VCD) cases between May 2019 and December 2021, consistent with low dengue incidence throughout the Aburrá Valley following wMel deployments. Nevertheless, VCD incidence was 45% lower (OR 0.55 [95% CI 0.25, 1.17]) and combined VCD/presumptive dengue incidence was 47% lower (OR 0.53 [95% CI 0.30, 0.93]) among participants resident in wMel-treated versus untreated neighbourhoods.Conclusions/significanceStable introduction of wMel into local Ae. aegypti populations was associated with a significant and sustained reduction in dengue incidence across three Colombian cities. These results from the largest contiguous Wolbachia releases to-date demonstrate the real-world effectiveness of the method across large urban populations and, alongside previously published results, support the reproducibility of this effectiveness across different ecological settings.Trial registrationNCT03631719

Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia.

BackgroundThe wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and has been shown to reduce the transmission of dengue and other Aedes-borne viruses. Here we report the entomological results from phased, large-scale releases of Wolbachia infected Ae. aegypti mosquitoes throughout three contiguous cities located in the Aburrá Valley, Colombia.Methodology/principal findingsLocal wMel Wolbachia-infected Ae. aegypti mosquitoes were generated and then released in an initial release pilot area in 2015-2016, which resulted in the establishment of Wolbachia in the local mosquito populations. Subsequent large-scale releases, mainly involving vehicle-based releases of adult mosquitoes along publicly accessible roads and streets, were undertaken across 29 comunas throughout Bello, Medellín and Itagüí Colombia between 2017-2022. In 9 comunas these were supplemented by egg releases that were undertaken by staff or community members. By the most recent monitoring, Wolbachia was found to be stable and established at consistent levels in local mosquito populations (>60% prevalence) in the majority (67%) of areas.ConclusionThese results, from the largest contiguous releases of wMel Wolbachia mosquitoes to date, highlight the operational feasibility of implementing the method in large urban settings. Based on results from previous studies, we expect that Wolbachia establishment will be sustained long term. Ongoing monitoring will confirm Wolbachia persistence in local mosquito populations and track its establishment in the remaining areas