39 research outputs found
Jatropha curcas biodiesel production in Kenya: economics and potential value chain development for smallholder farmers.
Modeling the differentiation of A- and C-type baroreceptor firing patterns
The baroreceptor neurons serve as the primary transducers of blood pressure
for the autonomic nervous system and are thus critical in enabling the body to
respond effectively to changes in blood pressure. These neurons can be
separated into two types (A and C) based on the myelination of their axons and
their distinct firing patterns elicited in response to specific pressure
stimuli. This study has developed a comprehensive model of the afferent
baroreceptor discharge built on physiological knowledge of arterial wall
mechanics, firing rate responses to controlled pressure stimuli, and ion
channel dynamics within the baroreceptor neurons. With this model, we were able
to predict firing rates observed in previously published experiments in both A-
and C-type neurons. These results were obtained by adjusting model parameters
determining the maximal ion-channel conductances. The observed variation in the
model parameters are hypothesized to correspond to physiological differences
between A- and C-type neurons. In agreement with published experimental
observations, our simulations suggest that a twofold lower potassium
conductance in C-type neurons is responsible for the observed sustained basal
firing, whereas a tenfold higher mechanosensitive conductance is responsible
for the greater firing rate observed in A-type neurons. A better understanding
of the difference between the two neuron types can potentially be used to gain
more insight into the underlying pathophysiology facilitating development of
targeted interventions improving baroreflex function in diseased individuals,
e.g. in patients with autonomic failure, a syndrome that is difficult to
diagnose in terms of its pathophysiology.Comment: Keywords: Baroreflex model, mechanosensitivity, A- and C-type
afferent baroreceptors, biophysical model, computational mode
The role of peptides in bone healing and regeneration: A systematic review
Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited. Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge
Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study
Differential expression of immunologic proteins in gingiva after socket preservation in mini pigs
235 ADMINISTRATION OF LEVOTHYROXINE IMPROVES THE PROPORTION OF TRANSFERABLE EMBRYOS FOLLOWING SUPEROVULATION IN JAPANESE BLACK CATTLE
Randomized Clinical Trial for Early Postoperative Complications of Ex-PRESS Implantation versus Trabeculectomy: Complications Postoperatively of Ex-PRESS versus Trabeculectomy Study (CPETS)
10.1038/srep26080Scientific Reports62608