Konzeption von Implementierungsschritten lebensfähiger Produktionsmanagementsysteme : Herleitung auf Basis einer Analogiebetrachtung zur kindlichen Entwicklung : Vortrag im Rahmen der mündlichen Doktorprüfung in Aachen am 29. Februar 2016

<p>Pairwise Kolmogorov-Smirnov tests to check the difference of the histograms of N-domain’s Q-scores of the final structures.</p

Simulation setup.

<p>A) Strucuture of SufI. N-, M-, and C-domains are depicted in blue, green, and red. Linkers that connet two domains are depicted in yellow. B) The codon-based elongation rate by Spencer <i>et al</i>’s algorithm. A threshold is introduced. The region where the elongation rate is slower than the threshold is drawn in red. C) The elongation schedule used in the CTF_codon simulations. Regions marked in red in B take long elongation time. D) Three CTF schems. The CTF_fast (dashed), the CTF_slow (dotted), and the CTF_codon (solid) lines. E) A schematic view of the system including the wall-and-tunnel potential.</p

Pairwise Kolmogorov-Smirnov tests to check the difference of the histograms of Q_total-scores of the final structures.

<p>Pairwise Kolmogorov-Smirnov tests to check the difference of the histograms of Q_total-scores of the final structures.</p

Representative time courses of folding simulations.

<p>A) A time course of a refolding trajectory. B) that of the CTF_codon. Some snapshots were drawn with the same color code as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004356#pcbi.1004356.g001" target="_blank">Fig 1A</a>.</p

Pairwise Mann-Whitney U tests tests to check the difference of the histograms of N-domain’s Q-scores of the final structures.

<p>Pairwise Mann-Whitney U tests tests to check the difference of the histograms of N-domain’s Q-scores of the final structures.</p

Pairwise Mann-Whitney U tests to check the difference of the histograms of Q_total-scores of the final structures.

<p>Pairwise Mann-Whitney U tests to check the difference of the histograms of Q_total-scores of the final structures.</p

The correlation between the inverse of elongation rate and the degree of folding in SufI.

<p>A) The degree of folding acquisition Δ<i>Q</i>_<i>i</i> after averaging over the window size 5. B) One over the translation rate computed from the Spencer <i>et al</i>.’s algorithm [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004356#pcbi.1004356.ref043" target="_blank">43</a>]. Experimentally-detected translational attenuation regions, 33-40kDa (281-326th residues) and 25-28kDa (214-240th residues), are shaded in grey [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004356#pcbi.1004356.ref016" target="_blank">16</a>]. C) The scattered plot of the translation time and the degree of folding. Here, residues 200–350 are used. The correlation coefficient was 0.51.</p

SufI folding networks for refolding (A) and for the codon-based CTF (B).

<p>The refolding network possesses 3284 nodes, while the codon-based CTF has only 820 nodes. The size of nodes represent their probabilities. The darkness of the node represents native-ness. The darker one is closer to the native. Diamonds, triangle, and stars indicate that N-, M-, and C-domains are pre-dominantly unfolded, respectively. When pre-dominantly unfolded domains are no uniquely decided, circles are used.</p

Misfolding in SufI domains.

<p>A) Fractions of misfolded domains at the end of simulations in four different schemes; the refolding (black), the CTF_fast (red), the CTF_slow (green), and the CTF_codon (blue). B) Representative final structures of misfolding. i) structure that is misfolded in N-domain. ii) Misfolded in M-domain. iii) (right) Misfolded in C-domain. (left) Native structure for comparison. See text for the explanation of the block arrows.</p

Impact of Early Reoperation following Living-Donor Liver Transplantation on Graft Survival

<div><p>Background</p><p>The reoperation rate remains high after liver transplantation and the impact of reoperation on graft and recipient outcome is unclear. The aim of our study is to <i>evaluate the impact of early reoperation following living-donor liver transplantation</i> (LDLT) on graft and recipient survival.</p><p>Methods</p><p>Recipients that underwent LDLT (n = 111) at the University of Tokyo Hospital between January 2007 and December 2012 were divided into two groups, a reoperation group (n = 27) and a non-reoperation group (n = 84), and case-control study was conducted.</p><p>Results</p><p>Early reoperation was performed in 27 recipients (24.3%). Mean time [standard deviation] from LDLT to reoperation was 10 [9.4] days. Female sex, Child-Pugh class C, Non-HCV etiology, fulminant hepatitis, and the amount of intraoperative fresh frozen plasma administered were identified as possibly predictive variables, among which females and the amount of FFP were identified as independent risk factors for early reoperation by multivariable analysis. The 3-, and 6- month graft survival rates were 88.9% (95%confidential intervals [CI], 70.7–96.4), and 85.2% (95%CI, 66.5–94.3), respectively, in the reoperation group (n = 27), and 95.2% (95%CI, 88.0–98.2), and 92.9% (95%CI, 85.0–96.8), respectively, in the non-reoperation group (n = 84) (the log-rank test, p = 0.31). The 12- and 36- month overall survival rates were 96.3% (95%CI, 77.9–99.5), and 88.3% (95%CI, 69.3–96.2), respectively, in the reoperation group, and 89.3% (95%CI, 80.7–94.3) and 88.0% (95%CI, 79.2–93.4), respectively, in the non-reoperation group (the log-rank test, p = 0.59).</p><p>Conclusions</p><p>Observed graft survival for the recipients who underwent reoperation was lower compared to those who did not undergo reoperation, though the result was not significantly different. Recipient overall survival with reoperation was comparable to that without reoperation. The present findings enhance the importance of vigilant surveillance for postoperative complication and surgical rescue at an early postoperative stage in the LDLT setting.</p></div