17 research outputs found

    P2Y12 inhibitor monotherapy after complex percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials

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    Abstract It remains unknown whether the recent trend of short dual antiplatelet therapy (DAPT) followed by P2Y12 inhibitor monotherapy can simply be applied to patients undergoing complex percutaneous coronary intervention (PCI). We performed a systematic review and meta-analysis to evaluate P2Y12 inhibitor monotherapy vs. conventional DAPT in patients undergoing complex PCI and non-complex PCI (PROSPERO: CRD42022335723). Primary endpoint was the 1-year Net Adverse Clinical Event (NACE). Among 5,323 screened studies, six randomized trials fulfilled the eligibility criteria. A total of 10,588 complex PCI patients (5,269 vs. 5,319 patients) and 25,618 non-complex PCI patients (12,820 vs 12,798 patients) were randomly assigned to P2Y12 inhibitor monotherapy vs. conventional DAPT. In complex PCI patients, P2Y12 inhibitor monotherapy was associated with a lower risk of NACE than conventional DAPT [Odds ratio (OR) 0.76, 95% confidence interval (CI) 0.63–0.91, P = 0.003], whereas in non-complex PCI patients, P2Y12 inhibitor monotherapy was associated with a trend toward lowering the risk of NACE (OR 0.86, 95% CI 0.72–1.02, P = 0.09). This meta-analysis across randomized trials demonstrated that a strategy of short DAPT followed by P2Y12 inhibitor monotherapy reduces the risk of 1-year NACE in patients undergoing complex PCI

    18-0177_Supplementary_Materials – Supplemental material for Drug-Coated Balloon Angioplasty in Atherosclerosis Patients With Popliteal Artery Involvement

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    <p>Supplemental material, 18-0177_Supplementary_Materials for Drug-Coated Balloon Angioplasty in Atherosclerosis Patients With Popliteal Artery Involvement by Tomoharu Dohi, Andrej Schmidt, Dierk Scheinert, Yvonne Bausback, Daijiro Kabata, Ayumi Shintani, Yasushi Sakata and Sabine Steiner in Journal of Endovascular Therapy</p

    Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

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    Suna S, Hikoso S, Yamada T On behalf of the OCVC-Heart Failure Investigators, et al. Study protocol for the PURSUIT-HFpEF study: a Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. BMJ Open 2020;10:e038294. doi: 10.1136/bmjopen-2020-03829
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