Interação genótipo x ambiente para produção de leite na raça Pardo Suíço, utilizando-se inferência Bayesiana.

Informações de 2.981 lactações referentes às primeiras lactações de vacas da raça Pardo-Suíça, filhas de 151 reprodutores, distribuídas em 62 rebanhos, com parições entre 1980 a 2002, foram utilizadas para se verificar a existência da heterogeneidade de variância entre rebanhos e o seu impacto na classificação de reprodutores. As produções de leite foram utilizadas para se classificar os rebanhos em níveis de alta e baixa produção. Utilizou-se um modelo animal que incluiu os efeitos fixos de rebanho-ano e estação de parto, efeito linear do período de lactação, linear e quadrático da idade da vaca ao parto, como covariáveis, além dos efeitos aleatórios de animal e ambiente temporário. Estimaram-se componentes de variância, considerando-se os rebanhos como uma única amostra e assumindo-se a produção de leite em cada nível de produção como característica diferente. Médias e componentes de variância foram maiores para o nível de alta produção, caracterizando a presença de heterogeneidade de variância entre os rebanhos. As estimativas de herdabilidade foram de 0,21 em ambos os níveis para a produção de leite e de 0,25 e 0,26 para os níveis de alta e baixa produção, respectivamente. As correlações genéticas entre os níveis foram de 0,48, indicando a presença de heterogeneidade de variâncias. Correlações de Spearman entre os valores genéticos dos reprodutores preditos em análise conjunta com o nível de alta produção foram altas, enquanto que correlações baixas foram observadas para o nível de produção baixo, para os 10, 20 e 30% dos melhores reprodutores. Reprodutores com proles em rebanhos mais variáveis estariam sendo melhores classificados na avaliação genética, quando se desconsidera a heterogeneidade de variânci

CD3e expression in HTLV-1-infected individuals is associated with proviral load and Tax expression

Financial support: FUNDHERP, CTC, INCTC, FAPESP, CNPq and CAPES

Pacing Ability in Elite Runners with Intellectual Impairment

Purpose. To understand how athletes invest their energy over a race, differences in pacing ability between athletes with and without intellectual impairment (II) were explored using a novel field test. Methods. Well-trained runners (n=67) participated in this study, including 34 runners with II (age = 24.4 +/- 4.5 years; IQ = 63.1 +/- 7.7) and 33 runners without II (age = 31.4 +/- 11.2 years). The ability to perform at a pre-planned submaximal pace was assessed. Two 400m running trials were performed on an athletics track, with an individually standardized velocity. In the first trial, the speed was imposed by auditory signals given in 20m-40m intervals, in combination with coach-feedback during the initial 200m. The participant was instructed to maintain this velocity without any feedback during the final 200m. In trial 2, no coach-feedback was permitted. Results. Repeated measures analyses revealed a significant between-groups effect. II-runners deviated more from the target time than runners without II. The significant trial x group interaction effect (F = 4.15, p<.05) revealed that the ability to self-regulate the pace during the final 200m improved for runners without II (Trial 1: 1.7 +/- 1.0s, Trial 2: 0.9 +/-0.8s) whereas the II-runners deviated even more in Trial 2 (4.4 +/- 4.3s), than in Trial 1 (3.2 +/- 3.9s). Conclusion. Our findings support the assumption that intellectual capacity is involved in pacing. It is demonstrated that II-runners have difficulties maintaining a preplanned submaximal velocity, and this study contributes to understanding problems II-exercisers might experience when exercising. With this field test, we can assess the impact of II on pacing and performance in individual athletes which will lead to a fair Paralympic classification-procedure

Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains)

Background: The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults who have nonhypoxic ischaemic encephalopathy acute brain injuries and conditions and are receiving invasive mechanical ventilation in the intensive care unit (ICU) is uncertain. Objective: The objective of this study was to summarise the protocol and statistical analysis plan for the Mega-ROX Brains trial. Design, setting, and participants: Mega-ROX Brains is an international randomised clinical trial, which will be conducted within an overarching 40,000-participant, registry-embedded clinical trial comparing conservative and liberal ICU oxygen therapy regimens. We expect to enrol between 7500 and 9500 participants with nonhypoxic ischaemic encephalopathy acute brain injuries and conditions who are receiving unplanned invasive mechanical ventilation in the ICU. Main outcome measures: The primary outcome is in-hospital all-cause mortality up to 90 d from the date of randomisation. Secondary outcomes include duration of survival, duration of mechanical ventilation, ICU length of stay, hospital length of stay, and the proportion of participants discharged home. Results and conclusions: Mega-ROX Brains will compare the effect of conservative vs. liberal oxygen therapy regimens on 90-day in-hospital mortality in adults in the ICU with acute brain injuries and conditions. The protocol and planned analyses are reported here to mitigate analysis bias. Trial Registration: Australian and New Zealand Clinical Trials Registry (ACTRN 12620000391976)

Evaluation of damage caused on Coffea arabica by a population of Pratylenchus coffeae considered non-pathogenic on coffee

Evaluation of damage caused on Coffea arabica by a population of Pratylenchus coffeae considered non-pathogenic on coffee Two greenhouse experiments were carried out in order to evaluate the damage caused on Arabica coffee (Coffea arabica) by an M(2) population of Pratylenchus coffeae, apparently non-pathogenic to coffee. Experiment 1, with `Catua Vermelho` coffee at stage of two leaf pairs and with the initial nematode densities (Pi) of 0; 333; 1,000; 3.000; and 9,000 per plant, demonstrated that M(2) can damage young coffee plants, although it is unable to reproduce on coffee roots. Experiment 2, with the same coffee cultivar and nematode densities, but with plants at stage of six leaf pairs, showed that the M2 population was unable to cause damage. Therefore, it was established that M(2) is a population of P. coffeae without reproduction on Arabica coffee, which causes damage only in the first generation on young coffee below stages of six leaf pairs