Baseline characteristics of the study population (N = 98).

<p>Data presented as n (%), median (range) or mean (± SD) as appropriate.</p><p># n = 50</p><p>*4 missing values</p><p>**1 missing value.</p><p>Baseline characteristics of the study population (N = 98).</p

Gestational age specific longitudinal reference ranges of the percent change (∆%) in maternal cardiac contractility and work from baseline to passive leg raising.

<p>The solid line represents the mean and the interrupted lines represent the 5^th and 95^th percentiles. ∆ACI, acceleration index; B. ∆VI, velocity index; C. ∆PEP, pre-ejection period; D. ∆LVET, left ventricular ejection time; E. ∆STR, systolic time ratio and F. ∆LCWI, left ventricular work index.</p

Longitudinal changes in parameters describing maternal cardiac contractility and work measured using impedance cardiography.

<p>A. ACI, acceleration index; B. VI, velocity index; C. PEP, pre-ejection period; D. LVET, left ventricular ejection time; E. STR, systolic time ratio and F. LCWI, left ventricular work index.</p

Mean differences between hemodynamic variables measured by impedance cardiography at baseline and 90 seconds after passive leg raising during the second half of pregnancy.

<p>Data are presented as mean values for the difference (delta-values) between the measurements recorded at PLR and baseline (95% confidence intervals). p <0.05 was considered as significant. GA, gestational age; SV, stroke volume (ml); CO, cardiac output (L/min); cardiac index (L/min/m²); HR, heart rate (beats/min); BPS, systolic blood pressure (mm Hg); BPD, diastolic blood pressure (mm Hg); MAP, mean arterial pressure (mm Hg); SVR, systemic vascular resistance (dyne s/cm⁵); SVRI, systemic vascular resistance index (dyne s m²/cm⁵); TFC, thoracic fluid content (1/kOhm); ACI, acceleration index (1/100 s²); LCWI, left ventricular work index (Kg m/m²); PEP, pre-ejection period (ms); LVET, left ventricular ejection time (ms); VI, velocity index (1/1000s) and STR, systolic time ratio (%).</p><p>Mean differences between hemodynamic variables measured by impedance cardiography at baseline and 90 seconds after passive leg raising during the second half of pregnancy.</p

Gestational age specific longitudinal reference ranges of the percent change (∆%) in maternal systemic blood flow, blood pressure, vascular resistance and thoracic fluid content measured from baseline to passive leg raising.

<p>The solid line represents the mean and the interrupted lines represent the 5^th and 95^th percentiles. A. ∆SV, stroke volume; B. ∆HR, heart rate; C. ∆CO, cardiac output; D. ∆MAP, mean arterial pressure; E. ∆SVR, systemic vascular resistance and F. ∆TFC, thoracic fluid content.</p

Longitudinal changes in maternal systemic blood flow, blood pressure, vascular resistance and thoracic fluid content during the second half of pregnancy.

<p>A. SV, stroke volume; B. HR, heart rate; C. CO, cardiac output; D. MAP, mean arterial pressure; E. SVR, systemic vascular resistance and F. TFC, thoracic fluid content.</p

Additional file 3: Figure S2. of Secular trends and correlates of physical activity: The Tromsø Study 1979-2008

Secular trends in sex-specific prevalence of WPA 1979–2008. (PDF 32 kb

Additional file 2: Table S1. of Secular trends and correlates of physical activity: The Tromsø Study 1979-2008

Characteristics of participants by number of surveys attended. (DOCX 17 kb

Additional file 1: of Pain sensitivity and analgesic use among 10,486 adults: the Tromsø study

In-depth description of the definitions of analgesic use. (DOCX 19 kb

Results of the quality assessment of the included studies by marker.

<p>Abbreviations: LNM, Lymphatic node metastasis; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; LVD, lymphatic vascular density.</p><p>Maximal score for any given category is 1.</p