The Wales Immunology Teaching Toolkit

   The Wales Immunology Teaching Toolkit is a collaborative project between Cardiff and Swansea Universities. The open Canvas course hosts a range of immunology and general lab teaching resources that can be freely used and embedded either into websites or VLEs. All resources can be accessed from: Wales Immunology Teaching Toolkit</p

Additional file 1: of Seasonal influenza vaccination in patients with COPD: a systematic literature review

Search strategy. (XLSX 33 kb

Additional file 2: of Seasonal influenza vaccination in patients with COPD: a systematic literature review

Summary tables Safety results. Table S1 COPD Exacerbations after seasonal influenza vaccination. Table S2 Spirometric results before, 1 week and 3–4 weeks after seasonal influenza vaccination. Table S3: Local and systemic effects after seasonal influenza vaccination (most frequent effects). (XLSX 93 kb

Preservation of healthy lean body mass and function during weight loss

Sustainable treatments for obesity are needed and novel pharmacotherapies that aid weight loss appear promising. In their proposed agenda, Pinkney and Tarrant1 highlight additional priorities towards behavioural approaches in people living with obesity alongside current and emerging medical treatment. We support these suggestions and would like to highlight a different but aligned area of importance: the preservation of healthy lean body mass (LBM), in particular, skeletal muscle and physical function, during periods of substantial weight loss. [...]</p

Additional file 1: of Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases

Sensitivity data for MMP and TIMP luminex assays. MMP/TIMP ratios in BAL in COPD and PLF subjects. (DOCX 171 kb

Additional file 1: of Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD

Table S1. Spearman’s correlation analysis between CT parameters and sputum markers (all sputum samples). Table S2. CT parameters in subjects according to sputum Bacterial PCR Detection. Figure S1. Scatterplots of (A) %LAA<− 950 against Pi10 (rho − 0.36***, p < 0.001) (B) E/I MLD against Pi10 (rho 0.18*, p 0.045) (C) %LAA<− 950 against E/I MLD (rho 0.47***, p < 0.001). (DOCX 74 kb

Additional file 2: of Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD

Table S1. Radiological findings at exacerbation. Table S2. Exacerbation treatment stratified by the presence or absence of radiographic pneumonic infiltrate. Table S3. Bacterial identification by culture and PCR in all exacerbation sputum samples and those exacerbation sputum samples with fewer than 30% squamous cells (considered high quality). Table S4. Bacterial and viral identification at exacerbation by culture (bacteria) and PCR (bacteria/viral). Table S5. Levels of inflammatory markers at paired stable and exacerbation visits. Table S6. Changes in levels of serum inflammatory markers between stable (pre-exacerbation) and exacerbation samples. Table S7. Levels of serum inflammatory markers at paired stable and exacerbation visits. The occurrence of the first infiltrate-associated exacerbation where available was prioritised, or first non-infiltrative exacerbation if not (subjects are therefore only represented once). Table S8. Lung function changes between nearest stable-state and exacerbation visits, stratified by the presence/absence of pneumonic infiltrate. Figure S1. The proportion of bacterial positive sputum samples at exacerbation by both culture and PCR. Figure S2. The lung microbiome (phylum) of exacerbations stratified by the presence or absence of pneumonic infiltrate. Figure S3. Area under the receiver operator curve analysis for CRP, fibrinogen and neutrophil count. (DOCX 232 kb