Association of genetic variants with renal function in Africans and in Caucasians-4

End across genotypes using the ASSOC program in S.A.G.E. in models without additional covariates. GFR: glomerular filtration rate measured using inulin clearance. ERPF: effective renal plasma flow measured using PAH clearance. RVR: renal vascular resistance.<p><b>Copyright information:</b></p><p>Taken from "Association of genetic variants with renal function in Africans and in Caucasians"</p><p>http://www.biomedcentral.com/1755-8794/1/21</p><p>BMC Medical Genomics 2008;1():21-21.</p><p>Published online 2 Jun 2008</p><p>PMCID:PMC2424071.</p><p></p

Association of genetic variants with renal function in Africans and in Caucasians-3

End across genotypes using the ASSOC program in S.A.G.E. in models without additional covariates. GFR: glomerular filtration rate measured using inulin clearance. ERPF: effective renal plasma flow measured using PAH clearance. RVR: renal vascular resistance.<p><b>Copyright information:</b></p><p>Taken from "Association of genetic variants with renal function in Africans and in Caucasians"</p><p>http://www.biomedcentral.com/1755-8794/1/21</p><p>BMC Medical Genomics 2008;1():21-21.</p><p>Published online 2 Jun 2008</p><p>PMCID:PMC2424071.</p><p></p

Association of genetic variants with renal function in Africans and in Caucasians-2

Nel shows the pattern of linkage disequilibrium in the HapMap CEU panel. We imputed genotypes for all HapMap SNPs in the region around . In this region, linkage disequilibrium patterns in CoLaus were similar to the ones observed in HapMap, although they were resolved at a coarser scale due to lower SNP density. Since it was not computationally feasible to combine imputation and permutation approaches, we plot P values calculated assuming the normal linear model. For directly genotyped SNPs, the differences between calculated and permutation P values were small. The top three hits (and P values) are rs17327624 (0.0006), rs4148733 (0.0008) and rs17327442 (0.0008). The former two were directly genotyped and are in strong LD (D' = 0.96 in CoLaus and 1.00 in HapMap CEU, r= 0.63 and 0.72 respectively), and the imputed SNP rs17327442 is in perfect LD with rs17327624 in HapMap CEU.<p><b>Copyright information:</b></p><p>Taken from "Association of genetic variants with renal function in Africans and in Caucasians"</p><p>http://www.biomedcentral.com/1755-8794/1/21</p><p>BMC Medical Genomics 2008;1():21-21.</p><p>Published online 2 Jun 2008</p><p>PMCID:PMC2424071.</p><p></p

Association of genetic variants with renal function in Africans and in Caucasians-1

End across genotypes using the ASSOC program in S.A.G.E. in models without additional covariates. GFR: glomerular filtration rate measured using inulin clearance. ERPF: effective renal plasma flow measured using PAH clearance. RVR: renal vascular resistance.<p><b>Copyright information:</b></p><p>Taken from "Association of genetic variants with renal function in Africans and in Caucasians"</p><p>http://www.biomedcentral.com/1755-8794/1/21</p><p>BMC Medical Genomics 2008;1():21-21.</p><p>Published online 2 Jun 2008</p><p>PMCID:PMC2424071.</p><p></p

Heat map of selected PheWAS associations.

<p>Associations are shown for each variant with each trait, for the set of all traits that had association with any -variant at 5% FDR. For each association, black circles are drawn with area proportional to the effect size point estimate (inner circle) and 95% upper confidence limit (outer circle), scaled relative to the maximum within each trait. The inner circle is colored according to the effect direction (blue to red) and significance (color scale according to association Z score, with corresponding q value cut-offs shown in the legend). Traits and [variants] are ordered using hierarchical clustering on Euclidean distances between columns [and rows] of the association Z score matrix.</p

Association and literature results.

<p>Summary of association statistics for study results and previously reported associations for Crohn’s disease, IBD, psoriasis, psoriatic arthritis and eczema.</p

Additional file 2: Table S2. of Communicating BRCA research results to patients enrolled in international clinical trials: lessons learnt from the AGO-OVAR 16 study

Shows the countries and respective populations that were involved in AGO-OVAR 16. (DOC 28 kb

Additional file 1: Table S1. of Communicating BRCA research results to patients enrolled in international clinical trials: lessons learnt from the AGO-OVAR 16 study

Lists names and affiliations of local Institutional Review Boards and Independent Ethics Committees that approved the study. (PDF 211 kb

Coverage of 257 Metabochip fine-mapping regions.

<p>Fraction of 1000 Genomes Project SNPs in strong linkage disequilibrium (r²≥.8) with HapMap 3 (green squares) or Metabochip (blue dots) SNPs as a function of minor allele frequencies: (A) 1000 Genomes Pilot 1 SNPs, (B) 1000 Genomes Phase 1 SNPs (May 2011 release).</p

Summary of Metabochip SNPs by trait: Fine-mapping and replication.

<p> <i>SNP counts are numbers of SNPs successfully manufactured on the Metabochip array.</i></p>*<p> <i>Waist-to-hip ratio and waist circumference were adjusted for body mass index.</i></p