Preclinical study of pharmacological activity of enterosorbente on the basis of montmorillonite

At present, enterosorbents based on mineral raw materials are in high demand among the population. However, there are no enterosorbents on the Russian pharmaceutical market on the basis of domestic mineral raw materials, to study the pharmacological activity of enterosorbent based on montmorillonite of Russian origin under experimental conditions. The methodological approach was based on the implementation of a complex of theoretical, pharmacological, toxicological, histological, biochemical, statistical methods. Models of experimental diarrhea, acute and toxic liver damage, acute experimental pancreatitis were selecte

EXPERIMENTAL STUDY OF THE ANTIDIARRHOEAL ACTIVITY OF MONTMORILLONITE-CONTAINING ENTEROSORBENT

Aim. To study the antidiarrhoeal activity of montmorillonite-based enterosorbent on the model of serotonin-induced diarrhea.Materials and methods. The study was performed on laboratory mice of both genders, acute diarrhea was induced by intraperitoneal injection of serotonin hydrochloride at a dose of 0.32 mg/kg, enterosorbent as an aqueous suspension was administered orally in a wide range of doses 30 minutes prior to serotonin administration. Within 4 hours, the time of diarrhea onset, the number of defecations, the fluid content in the fecal masses was considered. Morphological examination of the small intestine was carried out. Results. The administration of serotonin led to the development of diarrhea in 100% of animals in 12,8±1,2 minutes, the number of defecations increased 2,5 times compared to intact animals and was 19,5±0,5 times within 4 hours, the fecal masses were predominantly wet and liquid. The use of enterosorbent under the Crim_04 cipher in the maximum dose led to a delay in the development of diarrhea to 73,6±4,1 minutes, a reduction in the number of defecations to 9,4±0,1 and a significant inspissation of stool. The antidiarrhoeal effect of enterosorbent was confirmed morphologically.Conclusions. Montmorillonite-based enterosorbent under the laboratory cipher Crim_04 has a dose-dependent antidiarrhoeal activity in the modeling of serotonin-induced diarrhea

Physico-chemical properties of montmorillonite clays and their application in clinical practice (review)

The review is devoted to the medical application of montmorillonite clay minerals. Properties and mechanisms of action of enterosorbents. The properties of the enterosorbents include an absorption capacity and active surface. The mechanisms of action include the sorption of toxins in the gastrointestinal tract, the contact effect on the mucosa, enhancing the release of toxins in the gastrointestinal tract, increasing the metabolism and excretion of toxin

Preclinical study of pharmacological activity of enterosorbente on the basis of montmorillonite

At present, enterosorbents based on mineral raw materials are in high demand among the population. However, there are no enterosorbents on the Russian pharmaceutical market on the basis of domestic mineral raw materials, to study the pharmacological activity of enterosorbent based on montmorillonite of Russian origin under experimental conditions. The methodological approach was based on the implementation of a complex of theoretical, pharmacological, toxicological, histological, biochemical, statistical methods. Models of experimental diarrhea, acute and toxic liver damage, acute experimental pancreatitis were selecte

STUDY OF THE SORPTION ACTIVITY OF ENTEROSORBENT ON THE BASIS OF MONTMORILLONITEAGAINST THE E.coli ENTEROTHOXIN ON THE MODEL OF ISOLATED LOOPES OF THE INTESTINE

Aim. To study the sorption activity of enterosorbent based on montmorillonite under the laboratory cipher of Crim_04 against E.coli enterotoxin in vivo.Material and Methods. Isolated loops of the small intestine were formed in laboratory rats under anesthesia, and E. coli toxin was injected into the control loops at a dose of 2 μg/loop. The enterosorbent under the code Crim_04 in the form of water suspensions with concentrations of 50 mg/ml, 100 mg/ml and 200 mg/ml was injected into the lumen of the loops with toxin. After 4 hours, the expression of the fluid in the lumen of the intestine and its inhibition by the enterosorbent were evaluated. Comparison was Smekta.Results. The introduction of toxin into the lumen of the gut caused an increased fluid yield, the dilatation index for the control loops was 112,7±1,2 mg/cm versus 27,4±0,4 mg / cm in intact loops. The enterosorbent under the Crim_04 cipher exhibited a dose-dependent inhibitory effect on the fluid outlet into the lumen of the gut, at a concentration of 200 mg/ml, the dilation index was 31,6±0,8 mg / cm, inhibiting the fluid yield by 95,1%. This effect is confirmed morphologically, the morphometric parameters when using enterosorbent under the Crim_04 cipher are close to the level of intact loops.Conclusion. The montmorillonite-based enterosorbent under the laboratory cipher Crim_04 has a high sorption activity against the thermolabile cholera-like E. coli enterotoxin on the isolated bowel loop model

Nab-paclitaxel monotherapy in patients with metastatic breast cancer with visceral crisis: evaluation of efficacy and tolerability in clinical practice

The authors analysed the efficacy and safety of Nab-paclitaxel (Nab-R) monotherapy in patients with metastatic breast cancer with visceral crisis (VC) in the second- and further-line chemotherapy. The objective response rate (ORR) was 35.3% (6 of 17 persons). The most frequent side effects were general weakness, nausea, symptoms of peripheral neuropathy. The degree of toxicity did not exceed 1–2 in 60% of cases. The median time to progression was 7.8 months. (95% CI 6–10.6). The median overall survival for patients with VC was 14.9 months. (95% CI 12.0–16.9). Efficacy and controlled toxicity of Nab-P allows its use in pre-treated patients, including ones with VC