Additional file 4: Figure S2. of Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alstrรถm Syndrome provides mechanistic insight into shared and divergent phenotypes

Top genes found in downregulated pathways. Top 15 genes found in the greatest percentage of downregulated pathways in the (A) BBS model or the (B) Alstrรถm model. (PDF 164 kb

Additional file 5: Figure S3. of Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes

qRT-PCR validation of genes identified to be differentially expressed in opposing directions by RNA-Seq. Relative fold changes in expression of targeted genes in the Alström model (blue) and the BBS model (green) compared to control (red). *indicates p < 0.001; **indicates p < 0.05 (students t-test). (PDF 40 kb

Additional file 2: Table S1. of Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes

Differentially expressed genes in Alström model. All genes exhibiting significant changes in alms1-depleted zebrafish larvae, relative to control. Columns represent: ENSEMBL transcript ID (Feature.ID), gene name (gene_symbol), fold change (FC), p-value relative to control (p < 0.05), false discovery rate (FDR; FDR < 0.05). (PDF 159 kb

Additional file 2: of New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali

Contig pile-ups of the genome of 12 P. falciparum isolates from Mali aligned against the reference 3D7 genome. The genome assembly of each of the 12 isolates, represented by its constituent contigs (blue lines in between blue circles) is aligned against each of the 14 nuclear chromosomes of the reference P. falciparum 3D7 strain (black). The location of var gene sequences is shown (red) in both the 3D7 genome and the contigs aligned to it. (PDF 1608 kb