Fast high--voltage amplifiers for driving electro-optic modulators

We describe five high-voltage (60 to 550V peak to peak), high-speed (1-300ns rise time; 1.3-300MHz bandwidth) linear amplifiers for driving capacitive or resistive loads such as electro-optic modulators. The amplifiers use bipolar transistors in various topologies. Two use electron tubes to overcome the speed limitations of high-voltage semiconductors. All amplifiers have been built. Measured performance data is given for each.Comment: 9pages, 6figures, 6tables, to appear in Review of Scientific Instrument

Filling the "discursive void" in the construction of talent management policy knowledge: a Slovak case study [forthcoming]

HRM practices have fared well across national borders due to globalization. The field of international HRM has learnt us a great deal by exploring different effects on HRM implementation in different countries. Our symposium is rooted in two main streams of the literature, HRM effectiveness and HRM challenges of Multi-National Corporations (MNCs) in different regions of the world. Overall, it is acknowledged that HRM philosophy and practices are context specific and shaped by specific organizational dynamics as well as socio-cultural, economic and political contexts. Therefore, one must expect HRM policies and practices to differ in content and emphasis across national borders. Along with a long list of HRM-related issues, the literature does not pay attention yet enough to the involvement of line managers in HRM implementation in international context. In case of MNCs structures, HRM philosophies and policies are usually designed at the headquarters and communicated through towards subsidiaries, but it may be line subsidiaries-based managers who, in the end, take final responsibilities to implement centrally designed HRM systems. In case of indigenous organizations, the main logic remains: line managers stay responsible for the execution of HR practices

Open IP strategies for enabling sustainability transitions

As global societies are evolving to knowledge economies, intellectual property (IP) is becoming increasingly important. Contemporaneously, firms are opening up their innovation processes in contrast to the internally focused closed innovation paradigm, making IP of substantial relevance for firms as well as for societies. However, in spite of this relevance, existing literature about Open IP approaches is scarce, and most existing investigations are focusing on the software industry. This paper links Open IP to social and environmental issues, and particularly discusses IP strategies against the backdrop of sustainability transitions. The challenges for innovative, small companies to compete with incumbents and their role to contribute to sustainability transitions are demonstrated and suggestions for promising future research are presented

Impaired nutrient signaling and body weight control in a Na⁺ neutral amino acid cotransporter (Slc6a19)-deficient mouse

Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid transporters. To understand the role of epithelial neutral amino acid uptake in whole body homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0) amino acid transporter BᴼAT1 (Slc6a19). A general neutral aminoaciduria was observed similar to human Hartnup disorder which is caused by mutations in SLC6A19. Na⁺ -dependent uptake of neutral amino acids into the intestine and renal brush-border membrane vesicles was abolished. No compensatory increase of peptide transport or other neutral amino acid transporters was detected. Mice lacking BᴼAT1 showed a reduced body weight. When adapted to a standard 20% protein diet, BᴼAT1-deficient mice lost body weight rapidly on diets containing 6 or 40% protein. Secretion of insulin in response to food ingestion after fasting was blunted. In the intestine, amino acid signaling to the mammalian target of rapamycin (mTOR) pathway was reduced, whereas the GCN2/ATF4 stress response pathway was activated, indicating amino acid deprivation in epithelial cells. The results demonstrate that epithelial amino acid uptake is essential for optimal growth and body weight regulation.This work was supported by National Health and Medical Research Council Grant 525415, Australian Research Council Grant DP0877897, University of Sydney Bridging Grant RIMS2009-02579), and by an anonymous foundatio

Integrating intellectual property and sustainable business models: The SBM-IP canvas

Companies attempt to address global sustainability challenges through innovating products, services, and business models. This paper focuses on sustainable business model (SBM) innovations as a way to systemically transform businesses towards sustainability. It has been widely recognized that strategic approaches to using intellectual property (IP) need to be aligned with business model innovation for commercial success. Here we suggest that IP, aligned with SBMs, can also be used to create not only commercial, but also societal and environmental impact. Knowledge about how to best align IP with SBMs to drive sustainability transitions remains limited. We address this gap by developing an SBM-IP canvas that integrates IP considerations into each of the SBM canvas building blocks. We do this by employing relevant theoretical concepts from three literature streams, namely the business model (including SBM), IP, and innovation literature. We use case examples to illustrate different IP considerations that are relevant for the SBM-IP building blocks. These examples show that different IP types (e.g., patents, trademarks) and ways of using them (e.g., more or less restrictive licensing) are applied by companies in relation to the different building blocks. While covering new theoretical ground, the proposed SBM-IP canvas can help decision makers understand how they can use different IP types strategically to propose, create, deliver, and capture sustainable value for society, environment, and the business.</jats:p

Замена электродвигателя ПЭН турбоприводом на Кемеровской ТЭЦ

В данной работе рассматривается возможность замены электродвигателя ПЭН турбоприводом на Кемеровской ТЭЦ, с установкой турбопривода на существующий фундамент. Целью работы является оценка возможности увеличения отпуска электроэнергии от станции в результате уменьшения затрат на собственные нужды и повышение маневренности ТЭЦ.In this paper we consider the possibility of replacing the turbine drive motor PEN to Kemerovo CHP , with the installation of turbine drive on the existing foundation. The aim is to assess the possibility of increasing the supply of electric power from the plant by reducing the costs of their own needs and improving maneuverability CHP

Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo

We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm. cis-Regulatory analysis shows that transcription of the gene encoding the Notch ligand Delta is activated by the widely expressed Runx transcription factor, but spatially restricted by HesC-mediated repression through a site in the delta 5′UTR. Spatial transcription of the hesC gene, however, is controlled by Blimp1 repression. Blimp1 thus represses the repressor of delta, thereby permitting its transcription. The blimp1 gene is itself linked into a feedback circuit that includes the wnt8 signaling ligand gene, and we showed earlier that this circuit generates an expanding torus of blimp1 and wnt8 expression. The finding that delta expression is also controlled at the cis-regulatory level by the blimp1-wnt8 torus-generating subcircuit now explains the progression of Notch signaling from the mesoderm to the endoderm of the developing embryo. Thus the specific cis-regulatory linkages of the gene regulatory network encode the coordinated spatial expression of Wnt and Notch signaling as they sweep outward across the vegetal plate of the embryo