Two Lost Sonnets by Sterling A. Brown

This is the publisher's version, also available electronically from http://muse.jhu.edu/journals/callaloo/v021/21.4tidwell01.html.No abstract is available for this item

Double Conscious Brother in the Veil Toward an Intellectual Biography of Sterling A. Brown

This is the publisher's version, also available electronically from http://muse.jhu.edu/journals/callaloo/v021/21.4tidwell03.html.No abstract is available for this item

Sterling A. Brown

This is the publisher's version, also available from http://www.press.jhu.edu/journals/callaloo/index.html.No abstract is available for this item

Two Writers Sharing: Sterling A. Brown, Robert Frost, and In "Dives's Dive"

This is the publisher's version, also available electronically from http://www.jstor.org/stable/3042564?seq=1#page_scan_tab_contents.No abstract is available for this item

"Steady and Unaccusing": An Interview with Sterling A. Brown

This is the publisher's version, also available electronically from On author's personal website, departmental website or institutional repository. On a non-profit server. Publisher copyright and source must be acknowledged. In open access repositories, such as PubMed Central if required by law. Publisher's version/PDF may be used. Reviewed on 03/02/14.Since the early 1980s a series of symposia, public and academic awards, and other recognitions have testified to continuing popular and scholarly interest in Sterling A. Brown, poet, literary critic, teacher, anthologist, and raconteur. The Collected Poems of Sterling A. Brown (Harper & Row), for example, received the Lenore Marshall Poetry Prize for 1980 from Saturday Review. The Modern Language Association, at its December 1981 meeting, paid tribute to Brown's many years of distinguished service as a man of letters. A Black World special issue (September 1970) and Michael Harper and Robert Stepto's Chant of Saints: A Gathering of Afro-American Literature, Art, and Scholarship (1979) became the first two of many anthologies, critical studies, and journal special issues dedicated to him, for his enduring poetic innovations and his pioneering cultural criticism. At Howard University, on February 14, 1997, a symposium assessed the extent to which Brown's thinking reflected and influenced African-American and American views on culture and literature. His sensitive creative work and astute analyses are captured in four published collections of poetry, six critical studies and anthologies, and over forty essays and speeches, together with the regular book review column he wrote in the early issues of Opportunity: A Journal of Negro Life. The following interview--conducted August 2, 1980, but unpublished until now--was one he hoped personally to extend and revise. Nevertheless it offers in retrospect, we think, more testimony that Sterling A. Brown is a presence who remains, in the words from one of his favorite poems, "steady and unaccusing.

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second stage HAT, where parasites have invaded the central nervous system (CNS). The pharmacology of a potential orally available lead compound, N-methoxy-6-{5-[4-(N-methoxyamidino) phenyl]-furan-2-yl}-nicotinamidine (DB844), was evaluated in a vervet monkey model of second stage HAT, following promising results in mice. DB844 was administered orally to vervet monkeys, beginning 28 days post infection (DPI) with Trypanosoma brucei rhodesiense KETRI 2537. DB844 was absorbed and converted to the active metabolite 6-[5-(4-phenylamidinophenyl)-furanyl-2-y​l]-nicotinamide(DB820), exhibiting plasma Cmax values of 430 and 190 nM for DB844 and DB820, respectively, after the 14th dose at 6 mg/kg qd. A 100-fold reduction in blood trypanosome counts was observed within 24 h of the third dose and, at the end of treatment evaluation performed four days post the last drug dose, trypanosomes were not detected in the blood or cerebrospinal fluid of any monkey. However, some animals relapsed during the 300 days of post treatment monitoring, resulting in a cure rate of 3/8 (37.5%) and 3/7 (42.9%) for the 5 mg/kg×10 days and the 6 mg/kg×14 days dose regimens respectively. These DB844 efficacy data were an improvement compared with pentamidine and pafuramidine both of which were previously shown to be non-curative in this model of CNS stage HAT. These data show that synthesis of novel diamidines with improved activity against CNS-stage HAT was possible.This investigation received financial support from the Bill and Melinda Gates Foundation through the Consortium for Parasitic Drug Development

CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement

DB844 (CPD-594-12), N-methoxy-6-{5-[4-(N-methoxyamidino)phenyl]-furan-2-yl}- nicotinamidine, is an oral prodrug that has shown promising efficacy in both mouse and monkey models of second stage human African trypanosomiasis. However, gastrointestinal (GI) toxicity was observed with high doses in a vervet monkey safety study. In the current study, we compared the metabolism of DB844 by hepatic and extrahepatic cytochrome P450s to determine if differences in metabolite formation underlie the observed GI toxicity. DB844 undergoes sequential O-demethylation and N-dehydroxylation in the liver to form the active compound DB820 (CPD-593-12). However, extrahepatic CYP1A1 and CYP1B1 produced two new metabolites, MX and MY. Accurate mass and collision-induced dissociation mass spectrometry analyses of the metabolites supported proposed structures of MX and MY. In addition, MY was confirmed with a synthetic standard and detection of nitric oxide release when DB844 was incubated with CYP1A1. Taken altogether, we propose that MX is formed by insertion of an oxygen into the amidine C=N to form an oxaziridine, which is followed by intramolecular rearrangement of the adjacent O-methyl group and subsequent release of nitric oxide. The resulting imine ester, MX, is further hydrolyzed to form MY. These findings may contribute to furthering the understanding of toxicities associated with benzamidoxime- and benzmethamidoxime-containing molecules

Law and Policy Resource Guide: A Survey of Eminent Domain Law in Texas and the Nation

Eminent Domain is the power of the government or quasi-government entities to take private or public property interests through condemnation. Eminent Domain has been a significant issue since 1879 when, in the case of Boom Company v. Patterson, the Supreme Court first acknowledged that the power of eminent domain may be delegated by state legislatures to agencies and non-governmental entities. Thus, the era of legal takings began. Though an important legal dispute then, more recently eminent domain has blossomed into an enduring contentious social and political problem throughout the United States. The Fifth Amendment to the United States Constitution states, “nor shall private property be taken for public use, without just compensation.” Thus, in the wake of the now infamous decision in Kelo v. City of New London, where the Court upheld the taking of private property for purely economic benefit as a “public use,” the requirement of “just compensation” stands as the primary defender of constitutionally protected liberty under the federal constitution. In response to Kelo, many state legislatures passed a variety of eminent domain reforms specifically tailoring what qualifies as a public use and how just compensation should be calculated. Texas landowners recognize that the state’s population is growing at a rapid pace. There is an increasing need for more land and resources such as energy and transportation. But, private property rights are equally important, especially in Texas, and must be protected as well. Eminent domain and the condemnation process is not a willing buyer and willing seller transition; it is a legally forced sale. Therefore, it is necessary to consider further improvements to the laws that govern the use of eminent domain so Texas landowners can have more assurance that this process is fair and respectful of their private property rights when they are forced to relinquish their land. This report compiles statutes and information from the other forty-nine states to illustrate how they address key eminent domain issues. Further, this report endeavors to provide a neutral third voice in Texas to strike a more appropriate balance between individual’s property rights and the need for increased economic development. This report breaks down eminent domain into seven major topics that, in addition to Texas, seemed to be similar in many of the other states. These categories are: (1) Awarding of Attorneys’ Fee; (2) Compensation and Valuation; (3) Procedure Prior to Suit; (4) Condemnation Procedure; (5) What Cannot be Condemned; (6) Public Use & Authority to Condemn; and (7) Abandonment. In analyzing these seven categories, this report does not seek to advance a particular interest but only to provide information on how Texas law differs from other states. This report lays out trends seen across other states that are either similar or dissimilar to Texas, and additionally, discusses interesting and unique laws employed by other states that may be of interest to Texas policy makers. Our research found three dominant categories which tend to be major issues across the country: (1) the awarding of attorneys’ fees; (2) the valuation and measurement of just compensation; and (3) procedure prior to suit

GDI as an alternative guiding interaction style for occasional users.

Política de acceso abierto tomada de: https://www.springernature.com/gp/open-research/policies/book-policiesIt is usually taken for granted that Direct Manipulation is the best interaction style for inexperienced or non-expert users; moreover, this style of interaction is generally considered the best for almost every situation and user. The recent shifts in technology that we all are currently experiencing have given rise to a great deal of new kinds of users performing specific tasks in a variety of scenarios. In this paper, we focus on users who access a system occasionally, infrequently, or in an unplanned way; i.e., users who do not want or cannot afford a learning curve. We show that for them, Direct Manipulation is not always the most suitable style of interaction. We assess the advantages of guiding this kind of users, in particular through the guided interaction frame- work known as Goal Driven Interaction. GDI can be viewed as a superset of wizards providing support far beyond a few steps through dialogs. Indeed, GDI is an interaction style with characteristics of its own. We report a complete user test that backs up previous hypotheses. The analysis of empirical data proves that GDI is more time-efficient than DM, requiring fewer moderator assistances for the users. Post-test questionnaires confirmed that participants had a strong preference for GDI

Decision insight into stakeholder conflict for ERN.

Participatory modeling has become an important tool in facilitating resource decision making and dispute resolution. Approaches to modeling that are commonly used in this context often do not adequately account for important human factors. Current techniques provide insights into how certain human activities and variables affect resource outcomes; however, they do not directly simulate the complex variables that shape how, why, and under what conditions different human agents behave in ways that affect resources and human interactions related to them. Current approaches also do not adequately reveal how the effects of individual decisions scale up to have systemic level effects in complex resource systems. This lack of integration prevents the development of more robust models to support decision making and dispute resolution processes. Development of integrated tools is further hampered by the fact that collection of primary data for decision-making modeling is costly and time consuming. This project seeks to develop a new approach to resource modeling that incorporates both technical and behavioral modeling techniques into a single decision-making architecture. The modeling platform is enhanced by use of traditional and advanced processes and tools for expedited data capture. Specific objectives of the project are: (1) Develop a proof of concept for a new technical approach to resource modeling that combines the computational techniques of system dynamics and agent based modeling, (2) Develop an iterative, participatory modeling process supported with traditional and advance data capture techniques that may be utilized to facilitate decision making, dispute resolution, and collaborative learning processes, and (3) Examine potential applications of this technology and process. The development of this decision support architecture included both the engineering of the technology and the development of a participatory method to build and apply the technology. Stakeholder interaction with the model and associated data capture was facilitated through two very different modes of engagement, one a standard interface involving radio buttons, slider bars, graphs and plots, while the other utilized an immersive serious gaming interface. The decision support architecture developed through this project was piloted in the Middle Rio Grande Basin to examine how these tools might be utilized to promote enhanced understanding and decision-making in the context of complex water resource management issues. Potential applications of this architecture and its capacity to lead to enhanced understanding and decision-making was assessed through qualitative interviews with study participants who represented key stakeholders in the basin