22 research outputs found
Image_1_Dynamic typhoon visualization based on the integration of vector and scalar fields.pdf
Typhoons and other marine meteorological disasters often bring significant losses to human beings, and their data are characterized by multiple sources and scales, making traditional visualization methods unable to accurately express the characteristics and movement trends of the disasters. To address the above problems, this study proposes a typhoon dynamic visualization method based on the integration of vector and scalar fields. To address the above problems, this study proposes a typhoon dynamic visualization method based on the integration of vector and scalar fields. The method uses the ray casting method to visualize the volume rendering of typhoon scalar data, proposes a hybrid interpolation method to improve the visualization efficiency, and introduces the Sobel operator to achieve the edge enhancement of the volume rendering effect. Meanwhile, a particle system approach is used for dynamic visualization of typhoon vector data, where the tedious particle motion calculation is divided into two parts: parallel tracking and dynamic rendering to improve the visualization efficiency, and the Lagrangian field representation of the particle system is achieved. The experimental results show that the typhoon visualization method proposed in this study has better comprehensive visual effects, with a rendering frame rate greater than 44, and is able to stably and smoothly express the continuous spatio-temporal dynamic visualization features of typhoon.This study is conducive to the understanding of the evolution law of marine meteorological disasters and the adoption of disaster prevention and mitigation measures, and is of great significance for the expression of marine meteorological data such as typhoons and the analysis of their spatial and temporal changes.</p
Cyclosporine A‑Encapsulated pH/ROS Dual-Responsive Nanoformulations for the Targeted Treatment of Colitis in Mice
Inflammatory bowel disease (IBD) is a frequently occurring
disease
that seriously influences the patient’s quality of life. To
decrease adverse effects and improve efficacy of therapeutics, nanomedicines
have been widely used to treat IBD. However, how to thoroughly release
payloads under an inflammatory microenvironment and synergistic therapy
of IBD need to be further investigated. To address this issue, cyclosporine
A (CsA)-loaded, folic acid (FA)-modified, pH and reactive oxygen species
(ROS) dual-responsive nanoparticles (FA-CsA NPs) were fabricated using
pH/ROS-responsive material as carrier. The prepared FA-CsA NPs had
spherical shape and uniform size distribution and could smartly release
their payloads under acid and/or ROS microenvironment. In
vitro experiments demonstrated that FA-CsA NPs can be effectively
internalized by activated macrophages, and the internalized NPs could
down-regulate the expression of proinflammatory cytokines compared
to free drug or nontargeted NPs. In vivo experiments
verified that FA-CsA NPs significantly accumulated at inflammatory
colon tissues and the accumulated NPs obviously improved the symptoms
of colitis in mice without obvious adverse effects. In conclusion,
our results provided a candidate for the targeted treatment of IBD
Influence of Zwitterions on Thermomechanical Properties and Morphology of Acrylic Copolymers: Implications for Electroactive Applications
<i>n</i>-Butyl acrylate-based zwitterionomers and ionomers containing 3-[[2-(methacryloyloxy)ethyl](dimethyl)ammonio]-1-propanesulfonate (SBMA) and 2-[butyl(dimethyl)amino]ethyl methacrylate methanesulfonate (BDMAEMA MS), respectively, were synthesized using conventional free radical polymerization. Size-exclusion chromatography confirmed the molecular weights of the copolymers exceeded the critical molecular weight between entanglements (<i>M</i><sub>e</sub>) for poly(<i>n</i>-butyl acrylate). Differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS), and atomic force microscopy (AFM) revealed that zwitterionomers promoted more well-defined microphase separation than cationic analogues. Dynamic mechanical analyses (DMA) of the copolymers showed a rubbery plateau region due to physical cross-links between charges for zwitterionomers only. Since SBMA and BDMAEMA MS have very similar chemical structures, we attributed improved microphase separation and superior elastomeric performance of the zwitterionomers to stronger association between covalently tethered charged pairs
DataSheet_1_Genome-wide identification, expression and function analysis of the MTP gene family in tulip (Tulipa gesneriana).docx
Currently, soil heavy metal contamination is a severe issue, particularly with Cd pollution. The metal tolerance protein (MTP) proteins, as plant divalent cation transporters, play a crucial role in the transport and tolerance of heavy metals in plants. This study conducted comprehensive identification and characterization of the MTP gene family in the tulip. A total of 11 TgMTP genes were identified and phylogenetically classified into three subfamilies. Conserved motif and gene structure analyses unveiled commonalities and variations among subfamily members. Expression profiling demonstrated several TgMTPs were markedly upregulated under Cd exposure, including the TgMTP7.1. Heterologous expression in yeast validated that TgMTP7.1 could ameliorate Cd sensitivity and enhance its tolerance. These results provide primary insights into the MTP gene family in tulip. Phylogenetic relationships and functional analyses establish a framework for elucidating the transporters and molecular mechanisms governing Cd accumulation and distribution in tulip. Key TgMTPs identified, exemplified by TgMTP7.1, may illuminate molecular breeding efforts aimed at developing Cd-tolerant cultivars for the remediation of soil Cd contamination.</p
Table_1_Genome-wide identification, expression and function analysis of the MTP gene family in tulip (Tulipa gesneriana).xlsx
Currently, soil heavy metal contamination is a severe issue, particularly with Cd pollution. The metal tolerance protein (MTP) proteins, as plant divalent cation transporters, play a crucial role in the transport and tolerance of heavy metals in plants. This study conducted comprehensive identification and characterization of the MTP gene family in the tulip. A total of 11 TgMTP genes were identified and phylogenetically classified into three subfamilies. Conserved motif and gene structure analyses unveiled commonalities and variations among subfamily members. Expression profiling demonstrated several TgMTPs were markedly upregulated under Cd exposure, including the TgMTP7.1. Heterologous expression in yeast validated that TgMTP7.1 could ameliorate Cd sensitivity and enhance its tolerance. These results provide primary insights into the MTP gene family in tulip. Phylogenetic relationships and functional analyses establish a framework for elucidating the transporters and molecular mechanisms governing Cd accumulation and distribution in tulip. Key TgMTPs identified, exemplified by TgMTP7.1, may illuminate molecular breeding efforts aimed at developing Cd-tolerant cultivars for the remediation of soil Cd contamination.</p
RAFT Synthesis of ABA Triblock Copolymers as Ionic Liquid-Containing Electroactive Membranes
2-(Dimethylamino)Âethyl acrylate (DMAEA) imparts versatile
functionality
to polyÂ[Sty-<i>b</i>-(<i>n</i>BA-<i>co</i>-DMAEA)-<i>b</i>-Sty] ABA triblock copolymers. A controlled
synthetic strategy minimized chain transfer reactions and enabled
the preparation of high-molecular-weight ABA triblock copolymers with
relatively narrow PDIs between 1.39 and 1.44 using reversible addition–fragmentation
chain transfer (RAFT) polymerization. The presence of tertiary amine
functionality and their zwitterionic derivatives in the central blocks
of the triblock copolymers afforded tunable polarity toward ionic
liquids. Gravimetric measurements determined the swelling capacity
of the triblock copolymers for ionic liquids (IL) 1-ethyl-3-methylimidazolium
trifluoromethanesulfonate (EMIm TfO) and 1-ethyl-3-methylimidazolium
ethylsulfate (EMIm ES).
A correlation of differential scanning calorimetry (DSC), dynamic
mechanical analysis (DMA), and small-angle X-ray scattering (SAXS)
results revealed the impact of ionic liquid incorporation on the thermal
transitions, thermomechanical properties, and morphologies of the
triblock copolymers. IL-containing membranes of DMAEA-derived triblock
copolymers and EMIm TfO exhibited desirable rubbery plateau moduli
of ∼100 MPa and electromechanical actuation to a 4 V electrical
stimulus. Maintaining the mechanical ductility of polymer matrices
while increasing their ion-conductivity is paramount for future electroactive
devices
The knowledge map of active authors and co-cited authors on GWAS in AD.
The knowledge map of active authors and co-cited authors on GWAS in AD.</p
Locus validated for association with AD risk by GWAS.
Locus validated for association with AD risk by GWAS.</p
Top 10 institutions contributing to publications on GWAS in AD.
Top 10 institutions contributing to publications on GWAS in AD.</p
The clusters of keywords.
ObjectivesAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive and behavioral function. Studies have shown that genetic factors are one of the main causes of AD risk. genome-wide association study (GWAS), as a novel and effective tool for studying the genetic risk of diseases, has attracted attention from researchers in recent years and a large number of studies have been conducted. This study aims to summarize the literature on GWAS in AD by bibliometric methods, analyze the current status, research hotspots and future trends in this field.MethodsWe retrieved articles on GWAS in AD published between 2002 and 2022 from Web of Science. CiteSpace and VOSviewer software were applied to analyze the articles for the number of articles published, countries/regions and institutions of publication, authors and cited authors, highly cited literature, and research hotspots.ResultsWe retrieved a total of 2,751 articles. The United States had the highest number of publications in this field, and Columbia University was the institution with the most published articles. The identification of AD-related susceptibility genes and their effects on AD is one of the current research hotspots. Numerous risk genes have been identified, among which APOE, CLU, CD2AP, CD33, EPHA1, PICALM, CR1, ABCA7 and TREM2 are the current genes of interest. In addition, risk prediction for AD and research on other related diseases are also popular research directions in this field.ConclusionThis study conducted a comprehensive analysis of GWAS in AD and identified the current research hotspots and research trends. In addition, we also pointed out the shortcomings of current research and suggested future research directions. This study can provide researchers with information about the knowledge structure and emerging trends in the field of GWAS in AD and provide guidance for future research.</div