Mind Match: A Holistic App-Based Intervention for Post-Pandemic Adolescent Mental Health

The global COVID-19 pandemic and subsequent quarantine measures had profound implications for the mental well-being of adolescents. Studies have shown that adolescents who received MRIs post-pandemic demonstrated more severe mental health problems (Gotlib et al, 2021). As of 2021, more than 36% of DC youth who have depression did not receive any mental health care (NAMI, 2021). These statistics underscore the urgent need to address the mental health challenges faced by teenagers, particularly those from underrepresented backgrounds with limited access to mental health services (Mental health disparities: Diverse populations, 2017). In response to the downstream effects of COVID-19 on underrepresented adolescents\u27 mental health, our program, Mind Match, offers a comprehensive approach. It incorporates a mental health curriculum, an online certificate program, and a peer mentorship program. These components are facilitated through an innovative mental health monitoring application called Here 4 You, which also serves as a centralized platform for mental health support. Underclassmen engage in self-directed lessons, while upperclassmen can choose to become certified mentors for their peers. To monitor progress, our app will include a quarterly survey assessing depression, anxiety, social connectivity, and mental health knowledge. We will track academic performance, attendance, and in-school health resource utilization. With adequate funding, our app has the potential to mitigate the adverse effects of COVID-19 on adolescent mental health, making it an invaluable addition to school environments.https://hsrc.himmelfarb.gwu.edu/dchapp/1016/thumbnail.jp

Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) comprise a group of illnesses marked by memory and behavioral dysfunction that can occur in up to 50% of HIV patients despite adequate treatment with combination antiretroviral drugs. Iron dyshomeostasis exacerbates HIV-1 infection and plays a major role in Alzheimer’s disease pathogenesis. In addition, persons living with HIV demonstrate a high prevalence of neurodegenerative disorders, indicating that HAND provides a unique opportunity to study ferroptosis in these conditions. Both HIV and combination antiretroviral drugs increase the risk of ferroptosis by augmenting ferritin autophagy at the lysosomal level. As many viruses and their proteins exit host cells through lysosomal exocytosis, ferroptosis-driving molecules, iron, cathepsin B and calcium may be released from these organelles. Neurons and glial cells are highly susceptible to ferroptosis and neurodegeneration that engenders white and gray matter damage. Moreover, iron-activated microglia can engage in the aberrant elimination of viable neurons and synapses, further contributing to ferroptosis-induced neurodegeneration. In this mini review, we take a closer look at the role of iron in the pathogenesis of HAND and neurodegenerative disorders. In addition, we describe an epigenetic compensatory system, comprised of bromodomain-containing protein 4 (BRD4) and microRNA-29, that may counteract ferroptosis by activating cystine/glutamate antiporter, while lowering ferritin autophagy and iron regulatory protein-2. We also discuss potential interventions for lysosomal fitness, including ferroptosis blockers, lysosomal acidification, and cathepsin B inhibitors to achieve desirable therapeutic effects of ferroptosis-induced neurodegeneration

Adjusting to life in retirement: the protective role of new group memberships and identification as a retiree

Among the many factors that influence retirement adjustment, there is increasing recognition of the role played by people’s social relationships. In particular, research points to the benefits that joining new groups can have for people’s well-being when they experience life change. In three studies, we extend this research to assess the contribution that new groups and identities make to supporting the well-being and adjustment of people transitioning to retirement. Study 1, involving 302 retirees, demonstrates that joining new groups in retirement and developing a stronger sense of identification with retirees predicts life satisfaction after controlling for known predictors (e.g., financial planning, marital status, physical health status, retirement aspirations), while only retiree identification predicts adjustment. We then examine the extent to which multiple group memberships support retirement adjustment and well-being through the mediating role of new group memberships and retiree identification. This is first examined in a cross-sectional study of 90 retired academics (Study 2) and then in a two-wave study involving a general sample of 121 recent retirees (Study 3). Findings from both studies point to the importance of social group and identity gain in retirement adjustment and highlight the particular importance of retiree identification in the transition.This work was supported by the Australian Research Council [DP160102514]

Collective Action on Behalf of Women: Testing the Conceptual Distinction Between Traditional Collective Action and Small Acts in College Women

The current study examines the nature of actions that U.S. college women (N = 267) engage in to promote, protect, or enhance the welfare of other women. The study had two goals: 1) to distinguish between traditional forms of action (traditional collective action) and more informal, interpersonal, forms of action (small acts) among college women; and 2) to test whether the classic antecedents of collective action (gender identity, feminist identity, women’s activist identity, efficacy, appraisals of gender inequality, and injustice standards) are differentially predictive of these two types of participation. A confirmatory factor analysis provided strong support for these two distinct forms of participation: traditional collective action and small acts. Moreover, whereas women’s activist identity was the only predictor of traditional collective action, all predictors except gender identification and perceived group efficacy predicted small acts. Practical and theoretical implications for mobilizing college women for traditional collective action versus small acts are discussed

Adjusting to life in retirement: the protective role of new group memberships and identification as a retiree

Among the many factors that influence retirement adjustment, there is increasing recognition of the role played by people’s social relationships. In particular, research points to the benefits that joining new groups can have for people’s well-being when they experience life change. In three studies, we extend this research to assess the contribution that new groups and identities make to supporting the well-being and adjustment of people transitioning to retirement. Study 1, involving 302 retirees, demonstrates that joining new groups in retirement and developing a stronger sense of identification with retirees predicts life satisfaction after controlling for known predictors (e.g., financial planning, marital status, physical health status, retirement aspirations), while only retiree identification predicts adjustment. We then examine the extent to which multiple group memberships support retirement adjustment and well-being through the mediating role of new group memberships and retiree identification. This is first examined in a cross-sectional study of 90 retired academics (Study 2) and then in a two-wave study involving a general sample of 121 recent retirees (Study 3). Findings from both studies point to the importance of social group and identity gain in retirement adjustment and highlight the particular importance of retiree identification in the transition

The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): the CLL Research Consortium experience.

This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients with chronic lymphocytic leukaemia. The duration of both time to first treatment (TTFT) and overall survival (OS) were significantly longer than observed previously, and this is at least partly due to improved therapeutic options. Deletion 13q remains the most favourable prognostic group with median TTFT and OS from fluorescence in situ hybridization (FISH) testing of 72 months and >12 years, respectively. Deletion 11q had the poorest median TTFT (22 months) and 17p deletion the poorest median OS (5 years). The percentages of abnormal nuclei were significantly associated with differential TTFT for the trisomy 12, 13q and 17p deletion cohorts but not for the 11q deletion cohort. From the date of the first FISH study, patients with >85% 13q deletion nuclei had a notably shorter TTFT (24 months). Patients with ≤20% 17p deletion nuclei had longer median TTFT and OS from the date of the first FISH study (44 months and 11 years), and were more likely to be IGHV mutated

The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): the CLL Research Consortium experience

Summary This study revisited the Dohner prognostic hierarchy in a cohort of 1585 well-documented patients with chronic lymphocytic leukaemia. The duration of both time to first treatment (TTFT) and overall survival (OS) were significantly longer than observed previously, and this is at least partly due to improved therapeutic options. Deletion 13q remains the most favourable prognostic group with median TTFT and OS from fluorescence in situ hybridization (FISH) testing of 72 months and >12 years, respectively. Deletion 11q had the poorest median TTFT (22 months) and 17p deletion the poorest median OS (5 years). The percentages of abnormal nuclei were significantly associated with differential TTFT for the trisomy 12, 13q and 17p deletion cohorts but not for the 11q deletion cohort. From the date of the first FISH study, patients with >85% 13q deletion nuclei had a notably shorter TTFT (24 months). Patients with ≤20% 17p deletion nuclei had longer median TTFT and OS from the date of the first FISH study (44 months and 11 years), and were more likely to be IGHV mutated