1,477 research outputs found

    Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

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    Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control in randomized clinical trials and will hopefully be widely adopted by preclinical stroke research in the near future. Increasingly, funding bodies and review boards overseeing animal experiments are taking a proactive stance, and demand auditable quality control measures in preclinical research. Every good quality control system is based on its SOPs. This article introduces the concept of quality control and presents for the first time an SOP in experimental stroke research

    Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

    Get PDF
    Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control in randomized clinical trials and will hopefully be widely adopted by preclinical stroke research in the near future. Increasingly, funding bodies and review boards overseeing animal experiments are taking a proactive stance, and demand auditable quality control measures in preclinical research. Every good quality control system is based on its SOPs. This article introduces the concept of quality control and presents for the first time an SOP in experimental stroke research

    UCL (University College London) Libraries Masterplan: Library Report to Estates Management Committee January 2008

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    This document is a Report from UCL Library Services to UCL on Master Planning activities and outputs which have been undertaken to quantify use and development of estate in UCL Library Services. Prioritised options have been identified for the UCL Main and Science Libraries, and for a new central site option. This work has also addressed the needs of UCL for long-term offsite storage, which concludes that UCL needs to retain its facility at Wickford for at least the next ten years

    Is low fertility really a problem? Population aging, dependency, and consumption.

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    Copyright 2014 by the American Association for the Advancement of Science; all rights reserved.Longer lives and fertility far below the replacement level of 2.1 births per woman are leading to rapid population aging in many countries. Many observers are concerned that aging will adversely affect public finances and standards of living. Analysis of newly available National Transfer Accounts data for 40 countries shows that fertility well above replacement would typically be most beneficial for government budgets. However, fertility near replacement would be most beneficial for standards of living when the analysis includes the effects of age structure on families as well as governments. And fertility below replacement would maximize per capita consumption when the cost of providing capital for a growing labor force is taken into account. Although low fertility will indeed challenge government programs and very low fertility undermines living standards, we find that moderately low fertility and population decline favor the broader material standard of living

    The Gharial: Going Extinct Again

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