Additional file 1 of ADHD genetic burden associates with older epigenetic age: mediating roles of education, behavioral and sociodemographic factors among older adults

Additional file 1. Supplementary Tables and Material

Strongest associated SNPs detected by GWASs in the HRS discovery sample and comparisons in the ELSA replication sample, for immediate recall level (IR-L) and change (IR-C) and residual delayed recall level (rDR-L) and change (rDR-C).

<p>Strongest associated SNPs detected by GWASs in the HRS discovery sample and comparisons in the ELSA replication sample, for immediate recall level (IR-L) and change (IR-C) and residual delayed recall level (rDR-L) and change (rDR-C).</p

Regional plots showing meta-analyses results for rDR-L.

<p>(A) Results with the top associated SNP in the <i>APOE</i> region labeled. Two conditional meta-analyses were performed for rDR-L, (B) estimating the association with the <i>APOE</i> SNP shown (rs769449), conditioning on the top <i>TOMM40</i> SNP (rs2075650); and (C) estimating the association with the <i>TOMM40</i> SNP shown (rs2075650), conditioning on the top <i>APOE</i> SNP (rs769449). The y-axis shows -log₁₀ P-values; x-axis shows position of genes on chromosome 19 with SNPs 400-kb in both directions of the SNP of interest. The diamond represents the top SNP of interest. The circles represent each genotyped SNP in this region; the circle color indicates pairwise linkage disequilibrium (LD) in relation to the top SNP (calculated from hg19/1000 Genomes Nov 2014 EUR). The solid (blue) line indicates the recombination rate.</p

Age-adjusted values for estimated immediate recall (IR), delayed recall (DR), and residual delayed recall (rDR) in HRS.

<p>Age-adjusted values for estimated immediate recall (IR), delayed recall (DR), and residual delayed recall (rDR) in HRS.</p

Regional plots showing results of the meta-analyses of IR-C.

<p>(A) Meta-analysis results with the top SNP in <i>TOMM40</i> (rs157582) shown; (B) results when estimating the association with the <i>TOMM40</i> SNP shown (rs157582), conditioning on the top <i>APOE</i> SNP (rs769449); and (C) results when estimating the association with the <i>APOE</i> SNP (rs769449), conditioning on the top <i>TOMM40</i> SNP (rs157582). The y-axis shows -log₁₀ P-values; x-axis shows position of genes on chromosome 19 with SNPs 400-kb in both directions of the SNP of interest. The diamond represents the top SNP of interest. The circles represent each genotyped SNP in this region; the circle color indicates pairwise linkage disequilibrium (LD) in relation to the top SNP (calculated from hg19/1000 Genomes Nov 2014 EUR). The solid (blue) line indicates the recombination rate.</p

Scores (as words recalled) for immediate, delayed, and residualized delayed recall among 20,650 participants in the HRS.

<p>Scores (as words recalled) for immediate, delayed, and residualized delayed recall among 20,650 participants in the HRS.</p

Characteristics of HRS participants at the first assessment point, tested for immediate and delayed recall between 1996 and 2012, in the HRS full and Non-Hispanic White (NHW) genotypic samples.

<p>Characteristics of HRS participants at the first assessment point, tested for immediate and delayed recall between 1996 and 2012, in the HRS full and Non-Hispanic White (NHW) genotypic samples.</p

P-values for all 1,198,956 SNP associations from GWAS on the HRS genetic sample.

<p>(A) Level of Immediate Recall (IR-L); (B) Change in Immediate Recall (IR-C); (C) Level of Residualized Delayed Recall (rDR-L); (D) Change in Residualized Delayed Recall (rDR-C). For these figures, the upper (red) horizontal line demarcates the threshold of p = -log(5.0x10^-08) and the lower (blue) horizontal line demarcates p = -log(1x10^-05). SNPs are arranged by their chromosomal position (x-axis).</p