Dry eye among patients at the eye clinic of a secondary referral hospital

Introduction: Dry eye is a common but under-diagnosed problem in the general population. Lack of standardised diagnostic protocol causes prevalence of dry eye varied widely in different populations. Nevertheless, effective management rests largely on the accurate diagnosis and identification of the contributing risk factors. Methods: In a cross sectional study, socio-demographic, lifestyle and medical history data were collected from 157 respondents. A validated six-item questionnaire was used to determine the dry eye symptoms. Dry eye was determined by using Schirmer’s test. Fluorescein staining test and tear break up time (TBUT) test were performed to characterise the dry eye. Results: Using the Schirmer’s test, 33.8% of respondents had dry eyes. The likelihood of dry eye increased among Malay females in the seventh decade. The most frequently reported symptom was sensation of dryness of the eye. Although only 22.6% of dry eye cases were symptomatic, up to 47.2% of them may developed surface changes detectable by fluorescein dye test. Ethnicity (p=0.019) and diabetes mellitus (p=0.049) were significantly associated with dry eye. Conclusion: Dry eye could be subclinical but clinical tests in potential risk groups can lead to better detection of this condition and allow prescription of appropriate treatment for affected patients

Predictors of recurrence of major depressive disorder

A total of 201 patients with major depressive disorder from four hospitals in Malaysia were followed up for 5 years to determine the prognostic factors of recurrent major depressive disorder that could potentially contribute to improving the management of MDD patients. For each individual patient, at the time of recruitment as part of a case-control study, information was collected on recent threatening life events, personality and social and occupational functioning, while blood samples were collected to genotype single nucleotide polymorphisms of vitamin D receptor (VDR), zinc transporter-3 (ZnT3), dopamine transporter-1 (DAT1), brain-derived neurotropic factor (BDNF), serotonin receptor 1A (HT1A) and 2A (HT2A) genes. Kaplan-Meier and Cox-regression were used to estimate hazard functions for recurrence of major depressive disorder. Individuals with severe MDD in previous major depressive episodes had five and a half times higher hazard of developing recurrence compared to mild and moderate MDD (HR = 5.565, 95% CI = 1.631–18.994, p = 0.006). Individuals who scored higher on social avoidance had three and a half times higher hazard of recurrence of MDD (HR = 3.525, 95% CI = 1.349–9.209; p = 0.010). There was significant interaction between ApaI +64978C>A single nucleotide polymorphism and severity. The hazard ratio increased by 6.4 times from mild and moderate to severe MDD for A/A genotype while that for C/A genotype increased by 11.3 times. Social avoidance and severity of depression at first episode were prognostic of recurrence. Screening for personality factors at first encounter with MDD patients needs to be considered as part of the clinical practice. For those at risk of recurrence in relation to social avoidance, the psychological intervention prescribed should be customized to focus on this modifiable factor. Prompt and appropriate management of severe MDD is recommended to reduce risk of recurrence

Travellers' knowledge, attitudes and practices prevention of infectious diseases: a cross sectional study

International travel is common, increasing the risk for travel related infections, making it important to understand the knowledge, attitudes and practices (KAP) of international travellers regarding prevention of travel related illnesses. We aimed to determine the KAP of travellers at two Malaysian airports, in order to inform traveller health programs. We conducted face to face interviews with travellers at Kuala Lumpur International Airport and Sultan Abdul Aziz Shah Airport, Malaysia in 2014. Study subjects were selected via convenient sampling. Inclusion criteria were travellers aged ≥18 years who were departing from the studied airports, were able and willing to participate in the study. Subjects were asked about their KAP regarding various travel health subjects. The data from these interviews were collected, summarized and examined with SPSS version 21 and multiple logistic regression analysis to determine factors associated with poor KAP regarding travel health. A total of 316 subjects were included in the study; 57.6% were male and 55.4% were Malaysians. Forty point five percent of subjects sought pre-travel health advice. Of those who sought pre-travel health advice, 39.8% sought it from family or friends, 35.2% from the internet and 12.5% from a physicians. Fifty-two point eight percent of subjects had received pre-travel vaccinations. No subjects were traveling to a malaria high risk country as determined by the Centers for Disease Control and Prevention, 8.2% were travelling to a moderate risk country, 28.9% were travelling to a low risk country, 12.0% were travelling to a very low risk country and 50.9% were travelling to a country with no malaria risk. Four point one percent of subjects took malaria prophylaxis medication. On multivariate logistic regression analysis, the older the study subject age, the better the travel health knowledge [odds ratio (OR)=1.03; 95% confidence interval (CI): 1.01-1.05; p = 0.009]. Being female (OR: 1.92; 95%CI: 1.16-3.18; p = 0.011) and those who sought travel health advice (OR: 1.77; 95%CI: 1.06-2.95; p = 0.028) were more likely to have good practice on travel health. Therefore, awareness program should target the male travellers to improve health practices

Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects

Major depressive disorder (MDD) compromises the individual’s capacity for self-care and productivity. Single nucleotide polymorphisms (SNP) of a number of genes have been associated with MDD. The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc-glutamate homeostasis at the glutamatergic synapse, a disruption of which increases risk of MDD. We hypothesise that variation in SLC30A3 (rs11126936) SNP increases risk of MDD. We recruited 300 MDD cases and 300 controls, matched in the ratio of 1:1 by age, gender and ethnicity. PCR-restriction fragment length polymorphism analysis was used in DNA genotyping, validated by sequencing 10% of samples. Deviation from the Hardy-Weinberg equilibrium was tested using the chi-square test. Conditional logistic regression was used to estimate adjusted odds ratios, controlling for age, gender, ethnicity, occupation and family monthly income. Genotypes G/G and G/T showed two times greater odds of developing MDD compared to variant genotype T/T (OR=1.983, 95% CI=1.031-3.815; p=0.040 and OR=2.232, 95% CI=1.100-4.533; p=0.026 respectively). Carriers of genotypes G/G and G/T of the SNP rs11126936 in SLC30A3 are associated with increased risk of MDD

Incidence and prevalence of generalized pustular psoriasis in multiethnic Johor Bahru, Malaysia:a population-based cohort study using routinely captured electronic health records in the Teleprimary Care (TPC®) clinical information system from 2010 to 2020

BackgroundThere is limited understanding of the epidemiology of generalized pustular psoriasis (GPP) internationally, with no population-based estimates of GPP in South East Asia.ObjectivesTo determine the incidence and prevalence of GPP in the Malaysian population and characterize its flares and trigger factors.MethodsWe conducted a population-based cohort study using the Teleprimary Care database between January 2010 and December 2020. We identified 230 dermatologist-confirmed GPP cases using International Classification of Diseases, 10th revision, diagnostic codes. Annual prevalence and incidence rates were stratified by age, sex and ethnicity. We compared data regarding flares and trigger factors for patients with GPP who had associated psoriasis vulgaris (PV) with those who did not have associated PV.ResultsThe prevalence of GPP was 198 per million (267 women, 127 men) and incidence was 27.2 per million person-years [95% confidence interval (CI) 22.8–31.6]; 35.3 (28.4–42.2) per million person-years for women and 18.3 (13.1–23.5) per million person-years for men. Rates were higher in Chinese individuals [prevalence 271 per million; incidence 41.6 per million person-years (28.9–54.3)] than in the Malay population [prevalence 186; incidence 24.6 (19.4–29.7)] or the Indian ethnic group [prevalence 179; incidence 25.0 (13.8–36.3)]. Annual prevalence was consistently higher in women than in men and highest among the Chinese population, followed by the Indian and Malay populations. Overall, 67% of patients with GPP had associated PV. The prevalence and incidence of GPP without PV were lower than GPP with PV at 66 vs. 132 per million and 19.3 (95% CI 15.6–23.0) vs. 8.0 (95% CI 5.6–10.3) per million person-years, respectively. The mean age at GPP onset was 42.7 years (SD 18.4). A bimodal trend in the age of GPP onset was observed, with first and second peaks at age 20–29 years and age 50–59 years, respectively. Disease onset was significantly earlier in patients with GPP without PV than in those with PV [mean age 37.5 years (SD 20.7) vs. 44.9 years (SD 17.0), P = 0.026]. Flares occurred more frequently in patients without PV than in those with PV [mean number of flares per patient per year was 1.35 (SD 0.77) vs. 1.25 (SD 0.58), P = 0.039]. Common triggers of flares in patients with GPP who did not have PV were infections, pregnancy, menstruation and stress, whereas withdrawal of therapy, particularly systemic corticosteroids, was a more frequent trigger in patients with GPP who also had PV.ConclusionsOur findings contribute to the global mapping of GPP, which will help inform the management of this rare condition

Prevalence and factors associated with sexual dysfunction among middle-aged women in a multi-ethnic country: a cross sectional study in Malaysia

Introduction: This study aimed to determine the prevalence and factors associated with female sexual dysfunction in an outpatient clinic in Malaysia. Methods: The study was conducted among female patients aged 50 years and older who attended the outpatient clinic of a public hospital in Malaysia. A self-administered questionnaire was used that was based on the Malay version of the Female Sexual Function Index questionnaire. The predictors of female sexual dysfunction were identified using multivariate logistic regression analysis. Results: A total of 263 females were recruited in this study, with a mean age of 60.6 ± 6.7 years. The distribution of the respondents’ ethnicities was mostly Malay (42.2%), followed by Chinese (41.8%) and Indian (16.0%). The prevalence of female sexual dysfunction among participants was 68.8%. The prevalence of the subscales of female sexual dysfunction was as follows: desire (85.2%), satisfaction (74.9%), arousal (71.1%), lubrication (66.9%), pain (61.2%), and orgasm (60.8%). According to multivariate logistic regression, patients of Indian ethnicity had an increased risk of female sexual dysfunction (OR=16.60, 95% CI=2.54–108.63), and a higher frequency of sexual intercourse was correlated with a lower risk of female sexual dysfunction (OR=0.13, 95% CI=0.08–0.24). Conclusion: Seven-tenths of the middle-aged female patients attending the outpatient clinic suffered from female sexual dysfunction. Indian ethnicity and having a lower frequency of sexual intercourse were predictors of female sexual dysfunction. Future intervention studies are needed to address this problem

Smartphone ownership, digital literacy, and the mediating role of social connectedness and loneliness in improving the wellbeing of community-dwelling older adults of low socio-economic status in Singapore

During the COVID-19 pandemic, safe-distancing measures resulted in many community-dwelling older adults being socially isolated and lonely, with its attending negative impact on wellbeing and quality of life. While digital technology may have mitigated this, older adults of low socioeconomic status (SES) are more likely to be digitally excluded and hence susceptible to the adverse effects of social isolation and loneliness. This study aims to understand the factors that affect digital literacy, smartphone ownership, and willingness to participate in a digital literacy program (DLP), and to test the hypothesized relations between digital literacy, social connectedness, loneliness, wellbeing, and quality of life amongst community dwelling older adults of low SES.Info-communications Media Development Authority (IMDA)Ministry of Health (MOH)National Medical Research Council (NMRC)Published versionThis research is supported by the Singapore Ministry of Health’s National Medical Research Council under the Fellowship Programme by SingHealth Regional Health System, Population-based, Unified, Learning System for Enhanced and Sustainable (PULSES) Health Centre Grant (NMRC/ CG/C027/2017_SHS), the Healthy, Empowered and Active Living (HEAL) fund and the Infocomm Media Development Authority Digital for Life Fund

Smartphone ownership, digital literacy, and the mediating role of social connectedness and loneliness in improving the wellbeing of community-dwelling older adults of low socio-economic status in Singapore

Introduction During the COVID-19 pandemic, safe-distancing measures resulted in many community-dwelling older adults being socially isolated and lonely, with its attending negative impact on wellbeing and quality of life. While digital technology may have mitigated this, older adults of low socioeconomic status (SES) are more likely to be digitally excluded and hence susceptible to the adverse effects of social isolation and loneliness. This study aims to understand the factors that affect digital literacy, smartphone ownership, and willingness to participate in a digital literacy program (DLP), and to test the hypothesized relations between digital literacy, social connectedness, loneliness, wellbeing, and quality of life amongst community dwelling older adults of low SES. Materials and methods A questionnaire assessing digital literacy, social connectedness, wellbeing and quality of life was administered. Socio-demographic variables, pre-existing internet-enabled, and willingness to participate in a home-based DLP was also collected. Logistic regression was used to identify demographic factors associated with digital literacy, smartphone ownership, and willingness to enroll in a DLP. Serial mediation analysis was also performed using a structural equation model framework. Results A total of 302 participants were recruited. Female gender, older age, lower education levels were associated with lower digital literacy. Those who owned a smartphone tended to be younger and better educated. Older adults who were better educated, of Chinese descent (the ethnic majority in Singapore), and who had lower digital literacy, were most willing to enroll in the digital literacy education program. Social-use digital literacy had a positive indirect effect on well-being ( Discussion The results suggest there are demographic barriers to participation in DLPs and highlight the benefit of focusing on enhancing social-use digital literacy. Further study is needed to evaluate how well specific interventions to improve social-use digital literacy help to reduce social isolation and loneliness, and ultimately improve wellbeing and quality of life

Smartphone Ownership, Digital Literacy, and the Mediating Role of Connectedness and Loneliness In Improving The Wellbeing among Community-Dwelling Singaporean Older Adults of Low Socio-Economic Status

Importance: Safe-distancing measures used during the COVID-19 pandemic may exacerbate social isolation and loneliness with their attending negative consequences. Digital technology may mitigate the negative impact of safe-distancing measures; however, older adults of low socioeconomic status (SES) who may not be digitally literate remain a vulnerable population. Objective: To examine the relationship between digital literacy and social connectedness, loneliness, wellbeing, and quality of life (QOL) amongst older adults. To identify demographic factors associated with smartphone ownership, digital literacy, and willingness to enroll in a home-based digital literacy program. Design: Cross-sectional study. Setting: Convenience sampling of older adults receiving financial aid or living in rental flat referred to a volunteer-led digital literacy program. Participants: 302 community dwelling older adults who are ≥55 years old. Main Outcomes: Smartphone ownership, self-reported digital literacy, willingness to enroll in a digital literacy program; social connectedness (Lubben Social Connectedness Scale, LSNS-6), loneliness (UCLA 3-item scale, UCLA-3), wellbeing (Personal Wellbeing Score), and QOL (EQ-5D-3L [utility index], EQ VAS). Results: Social digital literacy had a positive indirect effect on both the wellbeing and QOL (mediated by social connectedness and perceived loneliness) of older adults, while instrumental digital literacy had a negative indirect effect on the two outcomes. 59.9% of participants owned an internet-enabled phone (smartphone). The median digital literacy index is 3 (score ranging from 0 to 13). Older adults who are younger and more educated were more likely to own a smartphone; while older adults who are more educated, Chinese (ethnic majority), have a smartphone, and lower digital literacy index were more likely to enroll in a home-based digital literacy education program. Conclusions and Relevance: During the COVID-19 pandemic, community dwelling older adults of low SES are socially isolated, lonely, and have low digital literacy. Interventions to improve digital literacy (especially the social domain) may help to reduce social isolation and loneliness, ultimately improving wellbeing and QOL

Measurement properties of the English and Chinese versions of the Functional Assessment of Cancer Therapy-Breast (FACT-B) in Asian breast cancer patients

The objective of the study was to examine the measurement properties of and comparability between the English and Chinese versions of the Functional Assessment of Cancer Therapy-Breast (FACT-B) in breast cancer patients in Singapore. This is an observational study of 271 Singaporean breast cancer patients. The known-group validity of FACT-B total score and Trial Outcome Index (TOI) were assessed in relation to performance status, evidence of disease, and treatment status cross-sectionally; responsiveness to change was assessed in relation to change in performance status longitudinally. Internal consistency and test-retest reliability were evaluated by the Cronbach's alpha and intraclass correlation coefficient (ICC), respectively. Multiple regression analyses were performed to compare the scores on the two language versions, adjusting for covariates. The FACT-B total score and TOI demonstrated known-group validity in differentiating patients with different clinical status. They showed high internal consistency and test-retest reliability, with Cronbach's alpha ranging from 0.87 to 0.91 and ICC ranging from 0.82 to 0.89. The English version was responsive to the change in performance status. The Chinese version was shown to be responsive to decline in performance status but the sample size of Chinese-speaking patients who improved in performance status was too small (N = 6) for conclusive analysis about responsiveness to improvement. Two items concerning sexuality had a high item non-response rate (50.2 and 14.4%). No practically significant difference was found in the total score and TOI between the two language versions despite minor differences in two of the 37 items. The English and Chinese versions of the FACT-B are valid, responsive, and reliable instruments in assessing health-related quality of life in breast cancer patients in Singapore. Data collected from the English and Chinese versions can be pooled and either version could be used for bilingual patients. © 2011 Springer Science+Business Media, LLC.Link_to_subscribed_fulltex