Anticuerpos anticardiolipina en pacientes con hipertensión arterial esencial

Los anticuerpos antifosfolípidos pueden activar el endotelio, modificar su función, alterar la regulación del tono vascular, producir daño renal, y así participar en la patogenia de la hipertensión arterial esencial.Antiphospholipid antibodies can activate the endothelium, alter their function, alter the regulation of vascular tone, cause kidney damage, and thus participate in the pathogenesis of essential hypertension.Fil: Diumenjo, M. S.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Testasecca, E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Testasecca, A.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Maneschi, E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Inmunologí

Factores trombogénicos sistémicos en paciente con síndrome coronario agudo con cinecoronariografía normal y patológica

En la fisiopatología del síndrome coronario agudo (SCA) sin evidencia de lesión ateromatosa oclusiva, podría participar un estado de hipertrombogenicidad sanguínea, generado por factores trombogénicos sistémicos, como los factores de riesgo cardiovascular y los que intervienen en el balance coagulación-anticoagulación, fibrinolisis y formación de fibrina. Objetivo: Estudiar y comparar los factores trombogénicos sistémicos en pacientes con SCA y cinecoronariografía (CCG) normal y patológica.In the pathophysiology of acute coronary syndrome (ACS) without evidence of occlusive atherosclerotic lesion, could participate a state of blood hipertrombogenicidad generated by systemic thrombogenic factors such as cardiovascular risk factors and those involved in the balance coagulation-anticoagulation, fibrinolysis and fibrin formation. Objective: Study and compare systemic thrombogenic factors in patients with ACS and normal and pathological coronary angiography (GCC).Fil: Testasecca, E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Testasecca, A.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Maneschi, E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Fragapane, P.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Diumenjo, M. S.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Inmunologí

Dynamic simulation of a 4th generation district heating network with the presence of prosumers

District Heating Network is identified as a promising technology for decarbonizing urban areas. Thanks to the surplus of heat available from distributed renewable energy plants, a typical heat consumer of the network could become an energy producer during the day (typically referred to as a “prosumer”). Most of the models for thermal grids developed during past years usually assumed a centralized production of the consumed heat. The increasing presence of prosumers will require accurate dynamic modelling to monitor the changes induced in the thermohydraulic parameters of the network. To fill this knowledge gap, this paper aims at developing a model of a thermal grid with prosumers in the TRNSYS environment. The model allows for the dynamic monitoring of the main thermohydraulic parameters of the network. To show these capabilities, a ring-shaped network serving a cluster of 10 residential users located in Palermo (Italy) was assumed as the case study. Different scenarios are investigated based on the presence of solar collectors, prosumers along the network, and cooling by an absorption chiller. The achievable energy and emissions savings are calculated. The results of the study show that even only decreasing the operating temperature can significantly reduce heat losses via the network pipes. In particular, a temperature drop from 100 °C to 80 °C can reduce heat losses by 27.1%. Furthermore, the heat losses can be decreased by up to 52.8% when the network temperature is lowered from 100 °C to 60 °C. Additionally, the presence of prosumers and the solar field could lead to a 31.3% reduction in the energy produced by the centralized plant and a 17.6% reduction in energy consumed for pumping

Thermodynamic-based method for supporting design and operation of thermal grids in presence of distributed energy producers

District heating networks are well-established technologies to efficiently cover the thermal demand of buildings. Recent research has been devoting large efforts to improve the design and management of these systems for integrating low-temperature heat coming from distributed sources such as industrial processes and renewable energy plants. Passing from a centralized to a decentralized approach in the heat supply, it is important to develop indicators that allow an assessment of the rational use of the available heat sources in supplying heating networks, and a quantification of the effect of inefficiencies on the unit cost of heat. To answer these questions, Exergy Cost Theory is here proposed. Thanks to the unit exergetic cost of heat, energy managers can (i) quantify the effects of thermodynamic inefficiencies occurring in the production and distribution on the final cost of heat, (ii) compare alternative systems for heat production, and (iii) monitor the performance of buildings’ substation over time. To show the capabilities of the method, some operating scenarios are compared for a cluster of five buildings in the tertiary sector interconnected by a thermal grid, where heat is produced by a cogeneration unit, an industrial process, and distributed heat pumps. Results suggest that moving from the centralized production of heat based on fossil fuels to a decentralized production with air-to-water heat pumps, the unit cost of heat can be decreased by almost 30% thanks to the improvement of thermodynamic efficiency. In addition, the analysis reveals a great sensitivity of unit exergetic cost to the maintenance in substations. The developed tool can provide thermodynamic-sound support for the design, operation, and monitoring of innovative district heating networks

The Ciona intestinalis immune-related galectin genes (CiLgals-a and CiLgals-b) are expressed by the gastric epithelium

The transcription of two Ciona intestinalis galectin genes (CiLgals-a and CiLgalseb) is uparegulated by LPS in the pharynxis (hemocytes, vessel epithelium, endostilar zones) which is retained the main organ of the immunity. In this ascidian, for the first time we show, by immunohistochemistry and in situ hybridization methods, that these two immune-related genes are expressed in the gastric epithelium of na\uefve ascidians, whereas the galectins appear to be only contained in the intestine columnar epithelium. In addition, according to previous results on the pharynx, the genes are also expressed and galectins produced by hemocytes scattered in the connective tissue surrounding the gut. The genes expression and galectin localization in several tissues, including the previous findings on the transcription upregulation, the constitutive expression of these genes by endostylar zones and by the gastric epithelium suggest a potential multifunctional role of these galectins. In this respect, it is of interest to define where the CiLgals are normally found as related to the tissue functions. Such an approach should be a starting point for further investigations

Exergoeconomics as a Cost-Accounting Method in Thermal Grids with the Presence of Renewable Energy Producers

Thermal grids are efficient, reliable, and sustainable technologies for satisfying the thermal demands of buildings. The capability to operate at a low temperature allows not only for the integration of heat produced by renewable energy sources but also for the storage of surplus electricity from the grid via “power to heat” technologies. Besides, in the future, heat consumers are expected to behave increasingly as “prosumers”, supplying in some periods heat produced by renewable energy plants on site. In this scenario, it is important to propose a method for the cost allocation among producers connected to the grid. In this regard, this paper proposes Exergoeco-nomics as a possible tool for rational cost assignment. To show the capabilities of the method, some operating scenarios are compared for a cluster of five buildings of the tertiary sector interconnected by a thermal grid. Based on exergoeconomic indicators, such as the exergy and exergoeconomic unit costs, insights into the cost formation process of the heat consumed by users are provided. Sensitivity analyses of heat unit cost to design and operating variables are also performed. Results show that in the presence of distributed producers, the heat unit cost could be approximately 33% lower than in the case of centralized production, due to the lower amount of irreversibility generated. Capital investment accounts for 20–28% of the heat unit cost

Regulation of self-glycosylation of reversibly glycosylated polypeptides from Solarum tuberosum

Reversibly glycosylated polypeptides (RGPs) belong to a family of self-glycosylating proteins believed to be involved in plant polysaccharide synthesis. The precise function of these enzymes remains to be elucidated. Our results showed that the RGP 38-kDa subunit is phosphorylated in potato extracts (Solanum tuberosum L.). An increase in the self-glycosylation of Solanum tuberosum RGP (StRGP) 38-kDa subunit was observed after alkaline phosphatase (AP) treatment. Our results suggest that phosphorylation of StRGP appears to regulate its self-glycosylation. It was determined that when the StRGP reaction was carried out in the presence of UDP-[14C]Glc as the sugar donor and then 1 mM UDP was added in a chase-out experiment, radioactive UDP-Glc was obtained indicating that StRGP reaction seems to be reversible. The anomeric configuration of transferred sugars to StRGP protein was also studied.Fil: Testasecca, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Wald, Flavia A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cozzarin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Moreno, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin