The upper two are the original micrographs and the lower two show the extracellular compartment highlighted in red

Note that the hydrocephalic brain has reduced extracellular space. Scale bar = 0.2 μm<p><b>Copyright information:</b></p><p>Taken from "Effect of hydrocephalus on rat brain extracellular compartment"</p><p>http://www.cerebrospinalfluidresearch.com/content/5/1/12</p><p>Cerebrospinal Fluid Research 2008;5():12-12.</p><p>Published online 10 Jul 2008</p><p>PMCID:PMC2488327.</p><p></p

In control rats, the cerebral cortex (A) and white matter (C) exhibit minimal immunoreactivity

In age matched hydrocephalic rats, perineuronal labeling is increased in the cerebral cortex (B) and periglial labeling is increased in the white matter (E). No labeling is seen in hydrocephalic white matter when the primary antibody is omitted (D). Scale bar = 100 μm. The bar graph shows densitometric analysis of immunolabeling (arbitrary units) in cortex layer 1 of control (C) and hydrocephalic (H) rats. The hydrocephalus-related increase is significant only in the 3-week rats (*= 0.0003 ANOVA, Bonferroni-Dunn; all groups n = 4). Note that significant changes were also present in the glia limitans.<p><b>Copyright information:</b></p><p>Taken from "Effect of hydrocephalus on rat brain extracellular compartment"</p><p>http://www.cerebrospinalfluidresearch.com/content/5/1/12</p><p>Cerebrospinal Fluid Research 2008;5():12-12.</p><p>Published online 10 Jul 2008</p><p>PMCID:PMC2488327.</p><p></p