3,452 research outputs found
Opinion diversity and community formation in adaptive networks
It is interesting and of significant importance to investigate how network
structures co-evolve with opinions. The existing models of such co-evolution
typically lead to the final states where network nodes either reach a global
consensus or break into separated communities, each of which holding its own
community consensus. Such results, however, can hardly explain the richness of
real-life observations that opinions are always diversified with no global or
even community consensus, and people seldom, if not never, totally cut off
themselves from dissenters. In this article, we show that, a simple model
integrating consensus formation, link rewiring and opinion change allows
complex system dynamics to emerge, driving the system into a dynamic
equilibrium with co-existence of diversified opinions. Specifically, similar
opinion holders may form into communities yet with no strict community
consensus; and rather than being separated into disconnected communities,
different communities remain to be interconnected by non-trivial proportion of
inter-community links. More importantly, we show that the complex dynamics may
lead to different numbers of communities at steady state with a given tolerance
between different opinion holders. We construct a framework for theoretically
analyzing the co-evolution process. Theoretical analysis and extensive
simulation results reveal some useful insights into the complex co-evolution
process, including the formation of dynamic equilibrium, the phase transition
between different steady states with different numbers of communities, and the
dynamics between opinion distribution and network modularity, etc.Comment: 12 pages, 8 figures, Journa
Ion trap long-range XY model for quantum state transfer and optimal spatial search
Linear ion trap chains are a promising platform for quantum computation and simulation. The XY
model with long-range interactions can be implemented with a single side-band Mølmer–Sørensen
scheme, giving interactions that decay as 1/r
α, where α parameterises the interaction range. Lower
α leads to longer range interactions, allowing faster long-range gate operations for quantum
computing. However, decreasing α causes an increased generation of coherent phonons and
appears to dephase the effective XY interaction model. We characterise and show how to correct for
this effect completely, allowing lower α interactions to be coherently implemented. Ion trap chains
are thus shown to be a viable platform for spatial quantum search in optimal O(
√
N) time, for N
ions. Finally, we introduce a O(
√
N) quantum state transfer protocol, with a qubit encoding that
maintains a high fidelity
Modeling the dynamic rupture propagation on heterogeneous faults with rate- and state-dependent friction
We investigate the effects of non-uniform distribution of constitutive parameters on the dynamic propagation of
an earthquake rupture. We use a 2D finite difference numerical method and we assume that the dynamic rupture
propagation is governed by a rate- and state-dependent constitutive law. We first discuss the results of several
numerical experiments performed with different values of the constitutive parameters a (to account for the direct
effect of friction), b (controlling the friction evolution) and L (the characteristic length-scale parameter) to
simulate the dynamic rupture propagation on homogeneous faults. Spontaneous dynamic ruptures can be simulated
on velocity weakening (a < b) fault patches: our results point out the dependence of the traction and slip velocity
evolution on the adopted constitutive parameters. We therefore model the dynamic rupture propagation on
heterogeneous faults. We use in this study the characterization of different frictional regimes proposed by
Boatwright and Cocco (1996) based on different values of the constitutive parameters a, b and L. Our numerical
simulations show that the heterogeneities of the L parameter affect the dynamic rupture propagation, control
the peak slip velocity and weakly modify the dynamic stress drop and the rupture velocity. Moreover, a barrier
can be simulated through a large contrast of L parameter. The heterogeneity of a and b parameters affects the
dynamic rupture propagation in a more complex way. A velocity strengthening area (a > b) can arrest a dynamic
rupture, but can be driven to an instability if suddenly loaded by the dynamic rupture front. Our simulations
provide a picture of the complex interactions between fault patches having different frictional properties and illustrate
how the traction and slip velocity evolutions are modified during the propagation on heterogeneous
faults. These results involve interesting implications for slip duration and fracture energy
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro
Although peroxisome proliferator-activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in hepatocarcinogenesis remains unclear. We investigated the therapeutic efficacy of PPAR
EXACT RUN LENGTH DISTRIBUTION OF THE DOUBLE SAMPLING X CHART WITH ESTIMATED PROCESS PARAMETERS
Since the run length distribution is generally highly skewed, a significant concern about focusing too much on the average run length (ARL) criterion is that we may miss some crucial information about a control chart’s performance. Thus it is important to investigate the entire run length distribution of a control chart for an in-depth understanding before implementing the chart in process monitoring. In this paper, the percentiles of the run length distribution for the double sampling (DS) X chart with estimated process parameters are computed. Knowledge of the percentiles of the run length distribution provides a more comprehensive understanding of the expected behaviour of the run length. This additional information includes the early false alarm, the skewness of the run length distribution, and the median run length (MRL). A comparison of the run length distribution between the optimal ARL-based and MRL-based DS X chart with estimated process parameters is presented in this paper. Examples of applications are given to aid practitioners to select the best design scheme of the DS X chart with estimated process parameters, based on their specific purpose
EXACT RUN LENGTH DISTRIBUTION OF THE DOUBLE SAMPLING X CHART WITH ESTIMATED PROCESS PARAMETERS
Since the run length distribution is generally highly skewed, a significant concern about focusing too much on the average run length (ARL) criterion is that we may miss some crucial information about a control chart’s performance. Thus it is important to investigate the entire run length distribution of a control chart for an in-depth understanding before implementing the chart in process monitoring. In this paper, the percentiles of the run length distribution for the double sampling (DS) X chart with estimated process parameters are computed. Knowledge of the percentiles of the run length distribution provides a more comprehensive understanding of the expected behaviour of the run length. This additional information includes the early false alarm, the skewness of the run length distribution, and the median run length (MRL). A comparison of the run length distribution between the optimal ARL-based and MRL-based DS X chart with estimated process parameters is presented in this paper. Examples of applications are given to aid practitioners to select the best design scheme of the DS X chart with estimated process parameters, based on their specific purpose
Predictors of allergen sensitization in Singapore children from birth to 3 years
10.1186/s13223-016-0161-xAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology121Article number 56GUSTO (Growing up towards Healthy Outcomes
Outpatient-Based Therapy of Oral Fludarabine and Subcutaneous Alemtuzumab for Asian Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
Background. Intravenous alemtuzumab and fludarabine are effective in combination for the treatment of chronic lymphocytic leukemia (CLL), but require hospital visits for intravenous injection. We performed a pilot study to assess the safety and efficacy of outpatient-based oral fludarabine with subcutaneous alemtuzumab (OFSA) for the treatment of relapsed/refractory CLL. Results. Depending on their response, patients were given two to six 28-day cycles of subcutaneous alemtuzumab 30 mg on days 1,3, and 5 and oral fludarabine 40 mg/m2/day for 5 days. Median patient age was 74. The lymphocyte counts of all five patients fell after the 1st cycle of treatment and reached normal/low levels on completion of 2 to 6 cycles of therapy. Platelet counts and hemoglobin were unaffected. All five patients achieved complete hematological remission, while two attained minimal residual disease negativity on 4-color flow cytometry. Conclusions. Our OFSA regimen was effective in elderly Asian patients with relapsed/refractory CLL, and it should be investigated further
Nanocasting Synthesis of Ultrafine WO3 Nanoparticles for Gas Sensing Applications
Ultrafine WO3 nanoparticles were synthesized by nanocasting route, using mesoporous SiO2 as a template. BET measurements showed a specific surface area of 700 m 2/gr for synthesized SiO2, while after impregnation and template removal, this area was reduced to 43 m 2/gr for WO3 nanoparticles. HRTEM results showed single crystalline nanoparticles with average particle size of about 5 nm possessing a monoclinic structure, which is the favorite crystal structure for gas sensing applications. Gas sensor was fabricated by deposition of WO3 nanoparticles between electrodes via low frequency AC electrophoretic deposition. Gas sensing measurements showed that this material has a high sensitivity to very low concentrations of NO2 at 250°C and 300°C
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