Impedance analysis of new PS internal dump design

The High Luminosity Large Hadron Collider (HL-LHC) project at CERN calls for increasing beam intensity in the injector chain. In the Proton Synchrotron (PS), a pre-injector of the LHC, these intensities can result in beam instabilities and potential RF heating of machine components, such that impedance mitigation measures are required. To study these intensity effects, the PS impedance model has been developed and is continuously updated. Each new machine element that is to be added into the accelerator requires an impedance study to minimize its contribution with respect to the machine's overall impedance budget. In such a context, this paper presents the impedance analysis of the new design of the internal beam dump for the PS, showing the design process required to reduce the impedance contribution of this element. Furthermore, the impedance analysis of the currently installed beam dump is analysed in order to compare the impedance contributions of the two designs

Design of the Target Dump Injection Segmented (TDIS) in the framework of the High Luminosity Large Hadron Collider (HL-LHC) project

The High Luminosity Large Hadron Collider (HL-LHC) Project at CERN calls for increasing beam brightness and intensity. In this scenario, most equipment has to be redesigned and rebuilt. In particular, beam intercepting devices (such as dumps, collimators, absorbers and scrapers) have to withstand impact or scraping of the new intense HL-LHC beams without failure. Furthermore, minimizing the electromagnetic beam-device interactions is also a key design driver since they can lead to beam instabilities and excessive thermo-mechanical loading of devices. In this context, the present study assesses the conceptual design quality of the new LHC injection protection absorber, the Target Dump Injection Segmented (TDIS), from an electromagnetic and thermo-mechanical perspective. This contribution analyzes the thermo-mechanical response of the device considering two cases: an accidental beam impact scenario and another accidental scenario with complete failure of the RFcontacts. In addition, this paper presents the preliminary results from the simulation of the energy deposited by the two counter-rotating beams circulating in the device

A multi-physics approach to simulate the RF heating 3D power map induced by the proton beam in a beam intercepting device

The project High Luminosity Large Hadron Collider (HL-LHC) calls for a streaking beam intensity and brightness in the LHC machine. In such a scenario, beam-environment electromagnetic interactions are a crucial topic: they could lead to uneven power deposition in machine equipment. The resulting irregular temperature distribution would generate local thermal gradients, this would create mechanical stresses which could lead to cracks and premature failure of accelerator devices. This work presents a method to study this phenomenon by means of coupled electro-thermomechanical simulations. Further, an example of application on a real HL-LHC device is also discussed

Acquired and inherited risk factors for splanchnic venous thrombosis

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CORD BLOOD PLATELET LYSATE: IN VITRO EVALUATION TO SUPPORT THE USE IN REGENERATIVE MEDICINE.

Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors in Vitro and in vivo. Due to its putative effect on tissue repair, the use of autologous PRP has become largely popular. Recently, a jellified PRP derivative obtained from umbilical cord blood (CB) has been utilized in vivo to treat mucosal and cutaneous lesions. Nevertheless, whether PRP derived from CB and adult blood display different potency in promoting cell growth in Vitro has been rarely investigated. In this study, we compared cytokine profile and mesenchymal cell growth supporting the ability of platelet lysate obtained from adult and cord blood. Our in vitro results strongly back the utilization of CB platelet lysate in vivo, as an efficacious, safe and inexpensive alternative to promote damaged tissue healing when the autologous PRP is contraindicated. Moreover, the policy of manufacturing CB platelet lysate can limit the current disposal of many collected CB units not suitable for transplant due to their low nucleated cell count

Vector Search with OpenAI Embeddings: Lucene Is All You Need

We provide a reproducible, end-to-end demonstration of vector search with OpenAI embeddings using Lucene on the popular MS MARCO passage ranking test collection. The main goal of our work is to challenge the prevailing narrative that a dedicated vector store is necessary to take advantage of recent advances in deep neural networks as applied to search. Quite the contrary, we show that hierarchical navigable small-world network (HNSW) indexes in Lucene are adequate to provide vector search capabilities in a standard bi-encoder architecture. This suggests that, from a simple cost-benefit analysis, there does not appear to be a compelling reason to introduce a dedicated vector store into a modern "AI stack" for search, since such applications have already received substantial investments in existing, widely deployed infrastructure

Analysis on the mechanical effects induced by beam impedance heating on the HL-LHC target dump injection segmented (TDIS) absorber

The High Luminosity Large Hadron Collider (HL-LHC) Project at CERN calls for increasing beam brightness and intensity. In such a scenario, critical accelerator devices need to be redesigned and rebuilt. Impedance is among the design drivers, since its thermo-mechanical effects could lead to premature device failures. In this context, the current work reports the results of a multiphysics study to assess the electromagnetic and thermo-mechanical behaviour of the Target Dump Injection Segmented (TDIS). It first discusses the outcomes of the impedance analysis performed to characterise the resistive wall and the high order resonant modes (HOMs) trapped in the TDIS structures. Then, their RF-heating effects and the related temperature distribution are considered. Finally, mechanical stresses induced by thermal gradients are studied in order to give a final validation on the design qualit

Childhood polycythemia vera and essential thrombocythemia: Does their pathogenesis overlap with that of adult patients?

[No abstract available