9 research outputs found
Differential Indicators of Diabetes-Induced Oxidative Stress in New Zealand White Rabbits: Role of Dietary Vitamin E Supplementation
Determination of reliable bioindicators of diabetes-induced oxidative
stress and the role of dietary vitamin E supplementation
were investigated. Blood (plasma) chemistries, lipid peroxidation
(LPO), and antioxidant enzyme activities were measured over
12 weeks in New Zealand White rabbits (control, diabetic, and diabetic +
vitamin E). Cholesterol and triglyceride levels did not correlate
with diabetic state. PlasmaLPOwas influenced by diabetes and
positively correlated with glucose concentration only, not cholesterol
or triglycerides. Liver glutathione peroxidase (GPX) activity
negatively correlated with glucose and triglyceride levels. Plasma
and erythrocyte GPX activities positively correlated with glucose,
cholesterol, and triglyceride concentrations. Liver superoxide dismutase
activity positively correlated with glucose and cholesterol
concentration. Vitamin E reduced plasma LPO, but did not affect
the diabetic state. Thus, plasmaLPOwas the most reliable indicator
of diabetes-induced oxidative stress. Antioxidant enzyme activities
and types of reactive oxygen species generated were tissue dependent.
Diabetes-induced oxidative stress is diminished by vitamin E
supplementation
Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial
Pathophysiology of T follicular helper cells in humans and mice
Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4(+) T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of TFH cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human TFH cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human TFH cells have revealed both similarities and differences between human and mouse TFH cells. Here we present the similarities and differences between mouse and human lymphoid organ-resident TFH cells and discuss the role of TFH cells in response to vaccines and in disease pathogenesis.Supported by the US National Institutes of Health (U19-AI057234, U19-AI082715
and U19-AI089987), the Alliance for Lupus Research, the Baylor Health Care
System (H.U.) and the Australian National Health and Medical Research
Council (C.G.V.)