69 research outputs found
Analysis of 2D THz-Raman spectroscopy using a non-Markovian Brownian oscillator model with nonlinear system-bath interactions
We explore and describe the roles of inter-molecular vibrations employing a
Brownian oscillator (BO) model with linear-linear (LL) and square-linear (SL)
system-bath interactions, which we use to analyze two-dimensional (2D)
THz-Raman spectra obtained by means of molecular dynamics (MD) simulations. In
addition to linear absorption (1D IR), we calculated 2D Raman-THz-THz,
THz-Raman-THz, and THz-THz-Raman signals for liquid formamide, water, and
methanol using an equilibrium non-equilibrium hybrid MD simulation. The
calculated 1D IR and 2D THz-Raman signals are compared with results obtained
from the LL+SL BO model applied through use of hierarchal Fokker-Planck
equations with non-perturbative and non-Markovian noise. We find that all of
the qualitative features of the 2D profiles of the signals obtained from the MD
simulations are reproduced with the LL+SL BO model, indicating that this model
captures the essential features of the inter-molecular motion. We analyze the
fitted 2D profiles in terms of anharmonicity, nonlinear polarizability, and
dephasing time. The origins of the echo peaks of the librational motion and the
elongated peaks parallel to the probe direction are elucidated using optical
Liouville paths.Comment: 37 pages with 14 figures and 3 table
PICO-LON Project for WIMPs search
Highly segmented inorganic crystal has been shown to have good performance
for dark matter search. The energy resolution of ultra thin and large area
NaI(Tl) scintillator has been developed. The estimated sensitivity for
spin-dependent excitation of 127I was discussed. The recent status of low
background measurement at Oto Cosmo Observatory is reportedComment: 3 pages, 1 figure, Proceedings of TAUP200
Tubular-Trabecular Type Basal Cell Adenoma of the Parotid Gland: A Patient Report
Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells. We report on a female patient with BCA that developed in the right parotid gland in her 50s. The present patient demonstrated a few tumor nests in the fibrous capsule, and her tumor was larger than usual. These facts made us suspect of malignancy. Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm. It was difficult to determine whether the ductal structures noted in the tumor capsule were invasive. By immunohistochemistry, tumor cells of the tubular nests were positive for cytokeratin 7 and that the outer cells of tubular nests were positive for alpha smooth muscle actin (SMA) and calponin. Tumor cells were immuno-negative for S-100 protein and glial fibrillary acidic protein. The Ki-67 labeling scores of the cells were extremely low (< 1%). We could achieve an accurate diagnosis of BCA by immunohistochemistry with MIB-1 and other markers
Residual Strain Dependence on Matrix Structure in RHQ-Nb3Al Wires by Neutron Diffraction Measurement
We prepared three types of non-Cu RHQ-Nb3Al wire samples with different
matrix structures: an all-Ta matrix,a composite matrix of Nb and Ta with a Ta
inter filament, and an all-Nb matrix. Neutron diffraction patterns of the wire
samples were measured at room temperature in J-PARC "TAKUMI". To obtain
residual strains of materials, we estimated lattice constant a by multi-peak
analysis in the wire. Powder sample of each wire was measured, where the powder
was considered to be strain-free. The grain size of all the powder samples was
below 0.02 mm. For wire sample with the all-Nb matrix, we also obtained lattice
spacing d by a single-peak analysis. Residual strains of Nb3Al filament were
estimated from the two analysis results and were compared. Result, residual
strains obtained from the multi-peak analysis showed a good accuracy with small
standard deviation. The multi-peak analysis results for the residual strains of
Nb3Al filament in the three samples were all tensile residual strain in the
axial direction, they are 0.12%, 0.12%, and 0.05% for the all-Ta matrix, the
composite matrix, and the all-Nb matrix, respectively. Difference in the
residual strain of Nb3Al filament between the composite and all-Nb matrix
samples indicates that type of inter-filament materials show a great effect on
the residual strain. In this paper, we report the method of measurement, method
of analysis, and results for residual strain in the tree types of non-Cu
RHO-Nb3Al wires.Comment: 7 pages, 8 figure
PICOLON dark matter search project
PICOLON (Pure Inorganic Crystal Observatory for LOw-energy Neutr(al)ino) aims to search for cosmic dark matter by high purity NaI(Tl) scintillator. We developed extremely pure NaI(Tl) crystal by hybrid purification method. The recent result of 210Pb in our NaI(Tl) is less than 5.7 μBq/kg. We will report the test experiment in the low-background measurement at Kamioka Underground Laboratory. The sensitivity for annual modulating signals and finding dark matter particles will be discussed
発症早期ALS患者に対する超高用量メチルコバラミンの有効性・安全性について : ランダム化比較試験
Importance:
Post hoc analysis in a phase 2/3 trial indicated ultra-high dose methylcobalamin slowed decline of the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) total score at week 16 as well as at week 182, without increase of adverse events, in patients with amyotrophic lateral sclerosis (ALS) who were enrolled within 1 year from onset.
Objective:
To validate the efficacy and safety of ultra-high dose methylcobalamin for patients with ALS enrolled within 1 year of onset.
Design:
A multicenter, placebo-controlled, double-blind, randomized phase 3 trial with 12-week observation and 16-week randomized period, conducted from October 2017 to September 2019.
Setting:
Twenty-five neurology centers in Japan.
Participants:
Patients with ALS diagnosed within 1 year of onset by the updated Awaji criteria were initially enrolled. Of those, patients fulfilling the following criteria after 12-week observation were eligible for randomization: 1- or 2-point decrease in ALSFRS-R total score, a percent forced vital capacity over 60%, no history of noninvasive respiratory support and tracheostomy, and being ambulant. The target number was 64 in both methylcobalamin and placebo groups. Of 203 patients enrolled in the observation, 130 patients (age, 61.0 ± 11.7 years; female, 56) met the criteria and were randomly assigned through an electronic web-response system to methylcobalamin or placebo (65 for each). Of these, 129 patients were eligible for the full analysis set, and 126 completed the double-blind stage.
Interventions:
Intramuscular injection of methylcobalamin 50 mg or placebo twice weekly for 16 weeks.
Main outcomes and measures:
The primary endpoint was change in ALSFRS-R total score from baseline to week 16 in the full analysis set.
Results:
The least-squares mean difference in ALSFRS-R total score at week 16 of the randomized period was 1.97 points greater with methylcobalamin than placebo (−2.66 versus −4.63; 95% CI, 0.44–3.50; P = 0.012). The incidence of adverse events was similar between the two groups.
Conclusions and relevance:
Ultra-high dose methylcobalamin was efficacious in slowing functional decline and safe in the 16-week treatment period in ALS patients in the early stage and with moderate progression rate.
Trial registration:
UMIN-CTR Identifier: UMIN000029588 (umin.ac.jp/ctr); ClinicalTrials.gov Identifier: NCT03548311 (clinicaltrials.gov
Twin Tower-shaped Anastomosis: Two Comitant Veins Anastomosed to a Single Recipient Vein in an End-to-end Fashion
In some cases of free flap transfer, two comitant veins must be anastomosed to a single suitable recipient vein to avoid congestion due to the lack of network between the two comitant veins. In this situation, both veins are mostly anastomosed to the recipient vein in an end-to-side fashion. However, the distal end of the recipient vein sometimes has to be cut to reach the comitant veins that are short in length. In such cases, we anastomose both of the comitant veins to a single recipient vein in an end-to-end fashion with a twin tower shape. The twin tower-shaped anastomosis technique involves two comitant veins in parallel anastomosed to a single recipient vein in an end-to-end fashion, and the gap of the two comitant veins is closed directly via an interrupted suture method. With this technique, two comitant veins and the recipient vein can be successfully anastomosed in an end-to-end fashion
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