ORT Broker Policy: Reduce Cost and Response Time Using Throttled Load Balancing Algorithm

AbstractCloud computing is simply define as “cloud” is delivery of demand services resources everything from application to data centers over the internet on a pay for use basis. In cloud computing load balancing is a technique to distribute the workload for balancing between two or more cloud server. Load balancing technique is defined some cases which are defining as guarantee continuity of the service provided manage, high traffic levels and always be ready for sudden peaks in traffic. Load balancing aims to optimize resource use, maintain the cost of data center and virtual machines, maximize throughput, minimize response time and avoid overload of any single resource. The main objective of this research paper is to reduce cost and response times using throttled load balancing policy across VM's in multi data center and optimise response time service broker policy. This study has evaluated throttled load balancing algorithm and their scheduling criteria like overall response time, Data center processing time and total cost of Virtual Machine and data transfer cost

THE APPLICATION OF CROSS–LAGGED PANEL ANALYSIS IN EDUCATIONAL RESEARCH

Cross–lagged panel analysis is found in the main stream of social, behavioral, medical, business and educational research. It is a form of quasi-experimental design used to determine whether the relationship between two variables is spurious i.e., due to a third variable and not due to causation. Cross–lagged panel analysis is a process used to determine which variable is the cause and which variable is the effect. It is an exploratory method of collecting information at two points in time i.e., time 1 and time 2, to clarify the causal relations between uncontrolled variables which could be tested more rigorously in an experimental setting. The Cross–lagged Panel Correlation (CLPC) is a low power test but better adapted than either multiple regression or factor analysis for answering many questions in longitudinal studies. It captures the dynamic relationship among the variables and allows the model to be controlled over time. This paper focuses on the 2w2v (two wave & two variable) design to describe a research method which can be used to explore the causal predominance relationship in the absence of a true experimental design, but only in a passive manner. Key words: cross–lagged panel correlation, spurious correlation, synchronous correlation, autocorrelation, stationarity, synchronicity.

Anesthetic management in a challenging case of primary pulmonary synovial sarcoma

Primary pulmonary synovial sarcoma is a very rare tumor. This tumor accounts for less than 0.5% of all lung neoplasia. While synovial sarcomas are commonly reported from periarticular tissues, they are often found in lung or thorax as a metastasis from an extrapulmonary primary. However, rarely they arise primarily from lung tissue. We report a case of primary pulmonary synovial sarcoma which was indenting the right side of the heart. He was managed with neoadjuvant chemotherapy followed by surgical resection. The anesthetic management was challenging. The focus was kept on stringent invasive as well as non-invasive monitoring of cardiac and respiratory parameters. The surgery was uneventful and the patient made a successful recovery.

Platelet in thrombo-inflammation: Unraveling new therapeutic targets

In the broad range of human diseases, thrombo-inflammation appears as a clinical manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that is recognized as thrombosis and inflammation of superficial veins. However, it is more hazardous when developed in the microvasculature of injured/inflamed/infected tissues and organs. Several diseases like sepsis and ischemia-reperfusion can cause formation of microvascular thrombosis subsequently leading to thrombo-inflammation. Thrombo-inflammation can also occur in cases of antiphospholipid syndrome, preeclampsia, sickle cell disease, bacterial and viral infection. One of the major contributors to thrombo-inflammation is the loss of normal anti-thrombotic and anti-inflammatory potential of the endothelial cells of vasculature. This manifest itself in the form of dysregulation of the coagulation pathway and complement system, pathologic platelet activation, and increased recruitment of leukocyte within the microvasculature. The role of platelets in hemostasis and formation of thrombi under pathologic and non-pathologic conditions is well established. Platelets are anucleate cells known for their essential role in primary hemostasis and the coagulation pathway. In recent years, studies provide strong evidence for the critical involvement of platelets in inflammatory processes like acute ischemic stroke, and viral infections like Coronavirus disease 2019 (COVID-19). This has encouraged the researchers to investigate the contribution of platelets in the pathology of various thrombo-inflammatory diseases. The inhibition of platelet surface receptors or their intracellular signaling which mediate initial platelet activation and adhesion might prove to be suitable targets in thrombo-inflammatory disorders. Thus, the present review summarizes the concept and mechanism of platelet signaling and briefly discuss their role in sterile and non-sterile thrombo-inflammation, with the emphasis on role of platelets in COVID-19 induced thrombo-inflammation. The aim of this review is to summarize the recent developments in deciphering the role of the platelets in thrombo-inflammation and discuss their potential as pharmaceutical targets

Robotic intraoperative tracheal repair during retrosternal malignant goiter excision: an anesthetic challenge

Thyroidectomy is the treatment of choice for large retrosternal goiters. These tumors often are large enough to require thoracotomy. Robotic surgery can help in avoiding thoracotomy and its associated post operative complications. Rarely, such tumors and their surgery can be complicated by tracheal tears. Such tears, especially those near the carina are difficult to repair and often require open thoracotomy. We described such a case where we avoided open thoracotomy and instead performed a minimally invasive robotic repair of tracheal tear. The maintenance of ventilation during this robotic repair was critical. A combination of several airway devices was used to allow the complex surgical repair to be executed without affecting ventilation

Ball valving laryngeal masses: a difficult “ball” in the anaesthetists’ court

Dynamic airway obstruction (also called ball-valve effect) is a serious condition often seen in glottic lesions. This is an anesthetic challenge as total airway obstruction can occur after the induction of general anesthesia. We present a case of a middle aged female who had a large laryngeal mass which was showing ball-valve effect. The patient had refused for tracheostomy despite it being the safest procedure in the circumstances. We then performed videolaryngoscopy and managed to intubate the patient with the help of some improvisation. The patient underwent a succesful and uneventful surgery

A Grusome trend in Homicidal Crimes, Cut Throat- A case series Medical Science The International Weekly Journal for Medicine The International Weekly Journal for Medicine

Globally, cut throat injuries account for approximately 5 % to 10 % of all traumatic injuries. The distinction between homicidal, suicidal and accidental wounding is a central issue for forensic experts. Cut-throat wounds are “effective ” in homicidal attacks with sharp & heavy sharp weapons. While accidental injuries in this topographic region caused by sharp objects are rarely seen and most often caused by broken glass. Suicidal incised neck wounds are typically multiple, being characterized by a number of hesitation cuts parallel to the wound. In these cases, presence or absence of particular features (e.g., hesitation marks, defensive wounds) can allow distinction between suicide and homicide, especially if further circumstances, i.e. atypical crime scene scenarios or missing suicide notes, need the forensic pathologist to have an incredulous approach regarding the manner of death. The present article describes five cases of homicidal cut throat injuries- history and autopsy findings are discussed. Key Words: sharp weapon injuries, cut-throat, homicide, autopsy. 1

Polysulfated Trehalose as a Novel Anticoagulant Agent with Dual Mode of Action

Physiological hemostatic balance is a coordinated outcome of counteracting coagulation and fibrinolytic systems. An imbalance of procoagulant and anticoagulant factors may result in life threatening thromboembolism. Presently, anticoagulant administration is the first line of therapy for the treatment of these conditions and several anticoagulants have been approved, including various forms of heparin. However, the polyanionic nature and multispecificity of heparin pose several complications. Generally, the polysulfated compounds with antithrombotic potential are thought to have feasible synthetic procedures with much less bleeding, thus having favourable safety profiles. Here we report the synthesis of a novel compound, trehalose octasulfate and the assessment of its anticoagulation potential. Molecular docking of trehalose and trehalose octasulfate with antithrombin showed a specificity switch in binding affinity on sulfation, where trehalose octasulfate interacts with critical residues of AT that are either directly involved in heparin binding or in the conformational rearrangement of AT on heparin binding. An in vitro analysis of trehalose octasulfate demonstrated prolonged clotting time. Lead compound when intravenously injected in occlusion induced thrombotic rats showed remarkable reduction in the size and weight of the clot at a low dose. Delay in coagulation time was observed by analysing blood plasma isolated from rats preinjected with trehalose octasulfate. A decrease in Adenosine 5′-Diphosphate (ADP) induced platelet aggregation indicated a probable dual anticoagulant and antiplatelet mechanism of action. To summarize, this study presents trehalose octasulfate as a novel, effective, dual acting antithrombotic agent