Pool temperature stratification analysis in CIRCE-ICE facility with RELAP5-3D© model and comparison with experimental tests

In the frame of heavy liquid metal (HLM) technology development, CIRCE pool facility at ENEA/Brasimone Research Center was updated by installing ICE (Integral Circulation Experiments) test section which simulates the thermal behavior of a primary system in a HLM cooled pool reactor. The experimental campaign led to the characterization of mixed convection and thermal stratification in a HLM pool in safety relevant conditions and to the distribution of experimental data for the validation of CFD and system codes. For this purpose, several thermocouples were installed into the pool using 4 vertical supports in different circumferential position for a total of 119 thermocouples [1][2]. The aim of this work is to investigate the capability of the system code RELAP5-3D (c) to simulate mixed convection and thermal stratification phenomena in a HLM pool in steady state conditions by comparing code results with experimental data. The pool has been simulated by a 3D component divided into 1728 volumes, 119 of which are centered in the exact position of the thermocouples. Three dimensional model of the pool is completed with a mono-dimensional nodalization of the primary main flow path. The results obtained by code simulations are compared with a steady state condition carried out in the experimental campaign. Results of axial, radial and azimuthal temperature profile into the pool are in agreement with the available experimental data Furthermore the code is able to well simulate operating conditions into the main flow path of the test section

Pre-test analysis of protected loss of primary pump transients in CIRCE-HERO facility

In the frame of LEADER project (Lead-cooled European Advanced Demonstration Reactor), a new configuration of the steam generator for ALFRED (Advanced Lead Fast Reactor European Demonstrator) was proposed. The new concept is a super-heated steam generator, double wall bayonet tube type with leakage monitoring [1]. In order to support the new steam generator concept, in the framework of Horizon 2020 SESAME project (thermal hydraulics Simulations and Experiments for the Safety Assessment of MEtal cooled reactors), the ENEA CIRCE pool facility will be refurbished to host the HERO (Heavy liquid mEtal pRessurized water cOoled tubes) test section to investigate a bundle of seven full scale bayonet tubes in ALFRED-like thermal hydraulics conditions. The aim of this work is to verify thermofluid dynamic performance of HERO during the transition from nominal to natural circulation condition. The simulations have been performed with RELAP5-3D© by using the validated geometrical model of the previous CIRCE-ICE test section [2], in which the preceding heat exchanger has been replaced by the new bayonet bundle model. Several calculations have been carried out to identify thermal hydraulics performance in different steady state conditions. The previous calculations represent the starting points of transient tests aimed at investigating the operation in natural circulation. The transient tests consist of the protected loss of primary pump, obtained by reducing feed-water mass flow to simulate the activation of DHR (Decay Heat Removal) system, and of the loss of DHR function in hot conditions, where feed-water mass flow rate is absent. According to simulations, in nominal conditions, HERO bayonet bundle offers excellent thermal hydraulic behavior and, moreover, it allows the operation in natural circulation

Post-test simulation of a PLOFA transient test in the CIRCE-HERO facility

CIRCE is a lead–bismuth eutectic alloy (LBE) pool facility aimed to simulate the primary system of a heavy liquid metal (HLM) cooled pool-type fast reactor. The experimental facility was implemented with a new test section, called HERO (Heavy liquid mEtal pRessurized water cOoled tubes), which consists of a steam generator composed of seven double-wall bayonet tubes (DWBT) with an active length of six meters. The experimental campaign aims to investigate HERO behavior, which is representative of the tubes that will compose ALFRED SG. In the framework of the Horizon 2020 SESAME project, a transient test was selected for the realization of a validation benchmark. The test consists of a protected loss of flow accident (PLOFA) simulating the shutdown of primary pumps, the reactor scram and the activation of the DHR system. A RELAP5-3D© nodalization scheme was developed in the pre-test phase at DIAEE of “Sapienza” University of Rome, providing useful information to the experimentalists. The model consisted to a mono-dimensional scheme of the primary flow path and the SG secondary side, and a multi-dimensional component simulating the large LBE pool. The analysis of experimental data, provided by ENEA, has suggested to improve the thermal–hydraulic model with a more detailed nodalization scheme of the secondary loop, looking to reproduce the asymmetries observed on the DWBTs operation. The paper summarizes the post-test activity performed in the frame of the H2020 SESAME project as a contribution of the benchmark activity, highlighting a global agreement between simulations and experiment for all the primary circuit physical quantities monitored. Then, the attention is focused on the secondary system operation, where uncertainties related to the boundary conditions affect the computational results

Vector and scalar form factors for K- and D-meson semileptonic decays from twisted mass fermions with Nf = 2

We present lattice results for the form factors relevant in the K -> pion and D -> pion semileptonic decays, obtained from simulations with two flavors of dynamical twisted-mass fermions and pion masses as light as 260 MeV. For K -> pion decays we discuss the estimates of the main sources of systematic uncertainties, including the quenching of the strange quark, leading to our final result f+(0) = 0.9560 (57) (62). Combined with the latest experimental data, our value of f+(0) implies for the CKM matrix element |Vus| the value 0.2267 (5) (20) consistent with the first-row CKM unitarity. For D -> pion decays the application of Heavy Meson Chiral Perturbation Theory allows to extrapolate our results for both the scalar and the vector form factors at the physical point with quite good accuracy, obtaining a nice agreement with the experimental data. In particular at zero-momentum transfer we obtain f+(0) = 0.64 (5).Comment: 8 pages, 4 figures, 1 table, proceedings of the XXVII Int'l Symposium on Lattice Field Theory (LAT2009), July 26-31 2009, Peking University, Beijing (China

Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway

we read with great interest the paper by Dr. Chen et al1, recently published in European Review for Medical and Pharmacological Sciences and titled ‘‘Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway’’. Authors concluded that lncRNA00673 is highly expressed and may be a potential target for the treatment of Hepatocellular Carcinoma (HCC). Moreover, according to authors, it can promote the proliferation and metastasis of HCC by the regulation of Notch signaling pathway. We congratulate the authors for their interesting work

A tensile strength apparatus with the facility to monitor negative pore-water pressure

This paper presents a new testing method for investigating the behaviour of clayey geomaterials subjected to a tensile (negative) total stress. The method includes the use of high capacity tensiometers to measure the pore-water pressure of the test specimen, an aspect which has not been demonstrated in any other direct tensile testing method. This addition allows interpretation of failure data in terms of effective stress rather than total stress, which is the approach that should be pursued in the saturated range. The test specimen shape and loading method have been modified from those commonly seen in existing literature to ensure that the direction of the major principal stress in the failure zone coincides with the direction of the externally applied tensile force, allowing for a more accurate analysis of tensile failure. Results are shown for saturated specimens and compared to results obtained for the same soil in uniaxial compression, using a modified version of the presented uniaxial tensile method, and a triaxial compression test. It is demonstrated that crack initiation occurs by shear failure if the data is interpreted in terms of effective stress rather than total stress, and that the failure mechanisms under tension do not differ from compression

Leading isospin-breaking corrections to pion, kaon and charmed-meson masses with Twisted-Mass fermions

We present a lattice computation of the isospin-breaking corrections to pseudoscalar meson masses using the gauge configurations produced by the European Twisted Mass collaboration with $N_f = 2 + 1 + 1$ dynamical quarks at three values of the lattice spacing ($a \simeq 0.062, 0.082$ and $0.089$ fm) with pion masses in the range $M_\pi \simeq 210 - 450$ MeV. The strange and charm quark masses are tuned at their physical values. We adopt the RM123 method based on the combined expansion of the path integral in powers of the $d$- and $u$-quark mass difference ($\widehat{m}_d - \widehat{m}_u$) and of the electromagnetic coupling $\alpha_{em}$. Within the quenched QED approximation, which neglects the effects of the sea-quark charges, and after the extrapolations to the physical pion mass and to the continuum and infinite volume limits, we provide results for the pion, kaon and (for the first time) charmed-meson mass splittings, for the prescription-dependent parameters $\epsilon_{\pi^0}$, \epsilon_\gamma(\overline{MS}, 2~\mbox{GeV}), \epsilon_{K^0}(\overline{MS}, 2~\mbox{GeV}), related to the violations of the Dashen's theorem, and for the light quark mass difference (\widehat{m}_d - \widehat{m}_u)(\overline{MS}, 2~\mbox{GeV}).Comment: 47 pages, 20 figures, 4 tables; comments on QED and QCD splitting prescriptions added; version to appear in PR

Steatosis, steatohepatitis and cancer immunotherapy: An intricate story

Immune checkpoint inhibitors represent one of the most significant recent advances in clinical oncology, since they dramatically improved the prognosis of deadly cancers such as melanomas and lung cancer. Treatment with these drugs may be complicated by the occurrence of clinically-relevant adverse drug reactions, most of which are immune-mediated, such as pneumonitis, colitis, endocrinopathies, nephritis, Stevens Johnson syndrome and toxic epidermal necrolysis. Drug-induced steatosis and steatohepatitis are not included among the typical forms of cancer immunotherapy-induced liver toxicity, which, instead, usually occurs as a panlobular hepatitis with prominent lymphocytic infiltrates. Nonetheless, non-alcoholic fatty liver disease is a risk factor for immunotherapy-induced hepatitis, and steatosis and steatohepatitis are frequently observed in this condition. In the present review we discuss how these pathology findings could be explained in the context of current models suggesting immune-mediated pathogenesis for steatohepatitis. We also review evidence suggesting that in patients with hepatocellular carcinoma, the presence of steatosis or steatohepatitis could predict a poor therapeutic response to these agents. How these findings could fit with immune-mediated mechanisms of these liver diseases will also be discussed