Understanding psychological health among women in sex work: the role of resilience and coping strategies

Division 06: Clinical and Community Psychology: DIV06-OC22 - Thematic Session - Prostitution: no. DIV06-OC22002Congress Theme: From Crisis to Sustainable Well Bein

The voices of women in sex work: a qualitative study of the role of rationalising their identity and ability in promoting resilience

Congress Theme: From Crisis to Sustainable Well BeingDivision 06: Clinical and Community Psychology: DIV06-OC22 - Thematic Session - Prostitution: no. DIV06-OC2200

Duration of untreated psychosis and its determinants in Chinese aAdults with First-episode Psychosis

Poster A. Schizophrenia and Psychotic Disorder

The clinical impact of chromosomal microarray on paediatric care in Hong Kong.

OBJECTIVE: To evaluate the clinical impact of chromosomal microarray (CMA) on the management of paediatric patients in Hong Kong. METHODS: We performed NimbleGen 135k oligonucleotide array on 327 children with intellectual disability (ID)/developmental delay (DD), autism spectrum disorders (ASD), and/or multiple congenital anomalies (MCAs) in a university-affiliated paediatric unit from January 2011 to May 2013. The medical records of patients were reviewed in September 2013, focusing on the pathogenic/likely pathogenic CMA findings and their "clinical actionability" based on established criteria. RESULTS: Thirty-seven patients were reported to have pathogenic/likely pathogenic results, while 40 had findings of unknown significance. This gives a detection rate of 11% for clinically significant (pathogenic/likely pathogenic) findings. The significant findings have prompted clinical actions in 28 out of 37 patients (75.7%), while the findings with unknown significance have led to further management recommendation in only 1 patient (p < 0.001). Nineteen out of the 28 management recommendations are "evidence-based" on either practice guidelines endorsed by a professional society (n = 9, Level 1) or peer-reviewed publications making medical management recommendation (n = 10, Level 2). CMA results impact medical management by precipitating referral to a specialist (n = 24); diagnostic testing (n = 25), surveillance of complications (n = 19), interventional procedure (n = 7), medication (n = 15) or lifestyle modification (n = 12). CONCLUSION: The application of CMA in children with ID/DD, ASD, and/or MCAs in Hong Kong results in a diagnostic yield of ∼ 11% for pathogenic/likely pathogenic results. Importantly the yield for clinically actionable results is 8.6%. We advocate using diagnostic yield of clinically actionable results to evaluate CMA as it provides information of both clinical validity and clinical utility. Furthermore, it incorporates evidence-based medicine into the practice of genomic medicine. The same framework can be applied to other genomic testing strategies enabled by next-generation sequencing

Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10

Squamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion. Copyright © 2012 Informa Healthcare USA, Inc.link_to_subscribed_fulltex

Quality of life and its determinants in adult-onset first-episode psychosis

Poster A. Schizophrenia and Psychotic Disorder

Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin

Background: Curcumin is a natural polyphenol. It is a potent suppressor of nuclear factor kappa B (NF-κB). High NF-κB levels have suppressive effect on E-cadherin (molecule related to cell-cell adhesion) in nasopharyngeal carcinoma (NPC) cells. We hypothesized that suppressing NF-κB by curcumin could up-regulate E-cadherin expression in NPC cells. Materials and Methods: NPC cell lines HK1 and HONE1 were used. Real-time quantitative PCR and Western blotting were used to examine the expression changes of NF-κB and E-cadherin. A mouse xenograft model was used to validate the results. Results: With curcumin treatment, NF-κB was down-regulated and E-cadherin was up-regulated in NPC cells. The negative correlation of NF-κB and E-cadherin was confirmed in the mouse xenograft model. Conclusion: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-KB and activating E-cadherin expression.link_to_subscribed_fulltex

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Sexual dysfunction in Chinese patients with first-episode psychosis: prevalence, clinical correlates, and functioning

Poster A. Schizophrenia and Psychotic Disorder