Gorlin syndrome in a patient with skin type VI

Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder that is characterized by multiple basal cell carcinomas developing at a young age, keratocystic odontogenic tumors of the jaw, palmar or plantar pits, calcification of the falx cerebri, and skeletal abnormalities. Nevoid basal cell carcinoma syndrome is caused by mutations in the PTCH1 or SUFU genes. Our patient with Fitzpatrick skin type VI was diagnosed with Gorlin syndrome based on the presentation of multiple major diagnostic characteristics. Although he is 33 years old, he has not developed any multiple basal cell carcinomas to date

Quantifying the ki-67 heterogeneity profile in prostate cancer.

BackgroundKi-67 is a robust predictive/prognostic marker in prostate cancer; however, tumor heterogeneity in prostate biopsy samples is not well studied.MethodsUsing an MRI/US fusion device, biopsy cores were obtained systematically and by targeting when indicated by MRI. Prostate cores containing cancer from 77 consecutive men were analyzed. The highest Ki-67 was used to determine interprostatic variation. Ki-67 range (highest minus lowest) was used to determine intraprostatic and intralesion variation. Apparent diffusion coefficient (ADC) values were evaluated in relation to Ki-67.ResultsInterprostatic Ki-67 mean ± standard deviation (SD) values for NCCN low (L), intermediate (I), and high (H) risk patients were 5.1 ± 3.8%, 7.4 ± 6.8%, and 12.0 ± 12.4% (ANOVA P = 0.013). Intraprostatic mean ± SD Ki-67 ranges in L, I, and H risk patients were 2.6 ± 3.6%, 5.3 ± 6.8%, and 10.9 ± 12.3% (ANOVA P = 0.027). Intralesion mean ± SD Ki-67 ranges in L, I, and H risk patients were 1.1 ± 0.9%, 5.2 ± 7.9%, and 8.1 ± 10.8% (ANOVA P = 0.22). ADC values at Ki-67 > and <7.1% were 860 ± 203 and 1036 ± 217, respectively (P = 0.0029).ConclusionsHigh risk patients have significantly higher inter- and intraprostatic Ki-67 heterogeneity. This needs to be considered when utilizing Ki-67 clinically

Mean-field behavior of the sandpile model below the upper critical dimension

We present results of large scale numerical simulations of the Bak, Tang and Wiesenfeld sandpile model. We analyze the critical behavior of the model in Euclidean dimensions $2\leq d\leq 6$. We consider a dissipative generalization of the model and study the avalanche size and duration distributions for different values of the lattice size and dissipation. We find that the scaling exponents in $d=4$ significantly differ from mean-field predictions, thus suggesting an upper critical dimension $d_c\geq 5$. Using the relations among the dissipation rate $\epsilon$ and the finite lattice size $L$, we find that a subset of the exponents displays mean-field values below the upper critical dimensions. This behavior is explained in terms of conservation laws.Comment: 4 RevTex pages, 2 eps figures embedde

Converting Treatment Plans From Helical Tomotherapy to L-Shape Linac: Clinical Workflow and Dosimetric Evaluation.

This work evaluated a commercial fallback planning workflow designed to provide cross-platform treatment planning and delivery. A total of 27 helical tomotherapy intensity-modulated radiotherapy plans covering 4 anatomical sites were selected, including 7 brain, 5 unilateral head and neck, 5 bilateral head and neck, 5 pelvis, and 5 prostate cases. All helical tomotherapy plans were converted to 7-field/9-field intensity-modulated radiotherapy and volumetric-modulated radiotherapy plans through fallback dose-mimicking algorithm using a 6-MV beam model. The planning target volume (PTV) coverage ( D1, D99, and homogeneity index) and organs at risk dose constraints were evaluated and compared. Overall, all 3 techniques resulted in relatively inferior target dose coverage compared to helical tomotherapy plans, with higher homogeneity index and maximum dose. The organs at risk dose ratio of fallback to helical tomotherapy plans covered a wide spectrum, from 0.87 to 1.11 on average for all sites, with fallback plans being superior for brain, pelvis, and prostate sites. The quality of fallback plans depends on the delivery technique, field numbers, and angles, as well as user selection of structures for organs at risk. In actual clinical scenario, fallback plans would typically be needed for 1 to 5 fractions of a treatment course in the event of machine breakdown. Our results suggested that <1% dose variance can be introduced in target coverage and/or organs at risk from fallback plans. The presented clinical workflow showed that the fallback plan generation typically takes 10 to 20 minutes per case. Fallback planning provides an expeditious and effective strategy for transferring patients cross platforms, and minimizing the untold risk of a patient missing treatment(s)

Moment analysis of the probability distributions of different sandpile models

We reconsider the moment analysis of the Bak-Tang-Wiesenfeld and the Manna sandpile model in two and three dimensions. In contrast to recently performed investigations our analysis turns out that the models are characterized by different scaling behavior, i.e., they belong to different universality classes.Comment: 6 pages, 6 figures, accepted for publication in Physical Review

“Lost in Translation? Transnational American Rock Music of the Sixties and its Misreading in 1980s China”

Excerpt from The Power of Culture: Encounters between China and the United States, edited by Priscilla Robert

Sphaleron rate at high temperature in 1+1 dimensions

We resolve the controversy in the high temperature behavior of the sphaleron rate in the abelian Higgs model in 1+1 dimensions. The $T^2$ behavior at intermediate lattice spacings is found to change into $T^{2/3}$ behavior in the continuum limit. The results are supported by analytic arguments that the classical approximation is good for this model.Comment: LATTICE98(electroweak