1 research outputs found
Rationally Designed Peptoids Modulate Aggregation of Amyloid-Beta 40
Alzheimer’s disease (AD) is
the most common form of dementia
and the sixth leading cause of death in the United States. Plaques
composed of aggregated amyloid-beta protein (Aβ) accumulate
between the neural cells in the brain and are associated with dementia
and cellular death. Many strategies have been investigated to prevent
Aβ self-assembly into disease-associated β-sheet amyloid
aggregates; however, a promising therapeutic has not yet been identified.
In this study, a peptoid-based mimic of the peptide KLVFF (residues
16–20 of Aβ) was tested for its ability to modulate Aβ
aggregation. Peptoid JPT1 includes chiral, aromatic side chains to
induce formation of a stable helical secondary structure that allows
for greater interaction between the aromatic side chains and the cross
β-sheet of Aβ. JPT1 was found to modulate Aβ40 aggregation,
specifically decreasing lag time to β-sheet aggregate formation
as well as the total number of fibrillar, β-sheet structured
aggregates formed. These results suggest that peptoids may be able
to limit the formation of Aβ aggregates that are associated
with AD