Identification of a new snake fossil from the Canary Islands using micro-CT techniques

Abstract and keywords in English and SpanishThere are no native snakes on the Canary Islands today. The recovery of a boid vertebra from Miocene deposits on Fuertaventura suggested snakes could have been present in the past, but this single small vertebra could have reached the island from the nearby African continent in the gut of a bird. Now, however, the articulated remains of a snake have been found in a volcanic cave on Fuerteventura. The specimen is covered by a calcitic matrix and is of uncertain age. Given the fragility of the remains and the difficulty of removing the matrix, we used micro-Ct scans to make three-dimensional digital models for study. These reveal that the bones belong to a 'colubrid' snake. = En el Mioceno de las Islas Canarias se ha citado la presencia de una vértebra de boido, que por su pequeño temaño pudo haber llegado a las islas desde el cercano continente africano en el tracto digestivo de un ave. Sin embargo, en un tubo volcánico de Fuerteventura se han encontrado restos de vértebras y costillas articuladas, cubiertas por una capa de calcita y de edad incierta, que pertenecen a una seriente de la familia 'Colubridae'. Para su estudio, dadas la fragilidad de los restos y la dificultad para eliminar la calcita, se utilizó un escáner micro CT para obtener modelos digitales tridimensionales.Evans, S.E., Martín-González, E., Jones, M.E.H., Sánchez-Pinto, L. & García-Talavera, F

Dengue

Lecture 49 ISBN e-book : 9781615045754International audienc

Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Background The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally. Methods Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Data were assessed overall and by WHO regions, sex, and index versus non-index cases. Findings Of the 61 612 individuals in the registry, 42 167 adults (21 999 [53·6%] women) from 56 countries were included in the study. Of these, 31 798 (75·4%) were diagnosed with the Dutch Lipid Clinic Network criteria, and 35 490 (84·2%) were from the WHO region of Europe. Median age of participants at entry in the registry was 46·2 years (IQR 34·3–58·0); median age at diagnosis of familial hypercholesterolaemia was 44·4 years (32·5–56·5), with 40·2% of participants younger than 40 years when diagnosed. Prevalence of cardiovascular risk factors increased progressively with age and varied by WHO region. Prevalence of coronary disease was 17·4% (2·1% for stroke and 5·2% for peripheral artery disease), increasing with concentrations of untreated LDL cholesterol, and was about two times lower in women than in men. Among patients receiving lipid-lowering medications, 16 803 (81·1%) were receiving statins and 3691 (21·2%) were on combination therapy, with greater use of more potent lipid-lowering medication in men than in women. Median LDL cholesterol was 5·43 mmol/L (IQR 4·32–6·72) among patients not taking lipid-lowering medications and 4·23 mmol/L (3·20–5·66) among those taking them. Among patients taking lipid-lowering medications, 2·7% had LDL cholesterol lower than 1·8 mmol/L; the use of combination therapy, particularly with three drugs and with proprotein convertase subtilisin–kexin type 9 inhibitors, was associated with a higher proportion and greater odds of having LDL cholesterol lower than 1·8 mmol/L. Compared with index cases, patients who were non-index cases were younger, with lower LDL cholesterol and lower prevalence of cardiovascular risk factors and cardiovascular diseases (all p<0·001). Interpretation Familial hypercholesterolaemia is diagnosed late. Guideline-recommended LDL cholesterol concentrations are infrequently achieved with single-drug therapy. Cardiovascular risk factors and presence of coronary disease were lower among non-index cases, who were diagnosed earlier. Earlier detection and greater use of combination therapies are required to reduce the global burden of familial hypercholesterolaemia. Funding Pfizer, Amgen, Merck Sharp & Dohme, Sanofi–Aventis, Daiichi Sankyo, and Regeneron