1 research outputs found
Triphenylphosphinecarboxamide: An Effective Reagent for the Reduction of Azides and Its Application to Nucleic Acid Detection
A series of triphenylphosphinecarboxamide
(TPPc) derivatives were
designed and synthesized as alternative reagents to triphenylphosphine
for the facile reduction of azides. The TPPc derivatives performed
as efficient reducing agents for the synthesis of primary amines without
the need for an additional hydrolysis procedure. The TPPc derivatives
were also applied to nucleic acid sensing using a RhAz-oligonucleotide
conjugate in a DNA-templated fluorogenic reaction