Effect of tapered magnetic field on expanding laser produced plasma for heavy ion inertial fusion

The ion source performance required for heavy ion inertial fusion (HIF) is beyond that used for current operating particle accelerator facilities. Ion sources are required to provide several tens to hundreds mA of low charge state heavy ions (q/A~100-200), such as Bi1+ to minimize the difficulty of a final focusing system caused by space charge repulsion force.[1] A laser ion source (LIS) is one of a promising candidate of such ion sources..

Operating experience with the laser ion source relevant the HIF application

Since March 2014, a laser ion source (LIS) has been used to provide high brightness low charge state heavy ion beams for regular routine operation of the hadron accelerator complex in Brookhaven National Laboratory (BNL)[1]. The peak current and pulse width of the typical beams from the LIS are several hundreds of microampere and about 200 microseconds, respectively. Of course, these specifications cannot be directly applied to the HIF. However, only by reducing the plasma drift distance to one tenth, the beam current and pulse width will become 1000 times and 1/10 respectively and these values are not far from the HIF’s requirements. Therefore, it would be useful to discuss some operational difficulties and to investigate what should be improved in the existing LIS in BNL toward the HIF application..

OPTICAL QPSK SIGNAL QUALITY DEGRADATION DUE TO PHASE ERROR OF PUMP LIGHT

The influence of pump phase error on phase-sensitive optical amplifier (PSA) repeaters and the waveform degradation due to chromatic dispersion and fiber nonlinearities in the optical multi-relay transmission of quadrature phase-shift keying phase-conjugated twin waves are considered theoretically. First, the influence of noise from the pump phase error, optical local oscillator, receiver, and the amplified spontaneous-emission (ASE) in PSA repeaters is investigated with the assumption that transmission fibers are linear lossy channels. The bit-error rate (BER) is estimated as a function of the signal-to-noise ratio, and the relationship between the number of transmission relays and the fiber launch power is clarified. Waveform degradation due to chromatic dispersion and the optical fiber nonlinearities in transmission fibers are investigated with the noiseless condition, and the maximum repeatable number as a function of the fiber launch power is calculated. Finally, we show the relationship among the maximum repeatable number, standard deviation of pump phase error in PSA repeaters, and the fiber launch power to clarify the optimum transmission condition with consideration of the noise and the waveform degradation

Effect of tapered magnetic field on expanding laser produced plasma for heavy ion inertial fusion

The ion source performance required for heavy ion inertial fusion (HIF) is beyond that used for current operating particle accelerator facilities. Ion sources are required to provide several tens to hundreds mA of low charge state heavy ions (q/A~100-200), such as Bi1+ to minimize the difficulty of a final focusing system caused by space charge repulsion force.[1] A laser ion source (LIS) is one of a promising candidate of such ion sources..

ヒトiPS細胞の骨分化誘導における逆転写-定量的リアルタイムPCR (RT-qPCR) で用いる参照遺伝子についての検討

Reverse transcription quantitative PCR (RT-qPCR) is used to quantify gene expression and require standardization with reference genes. We sought to identify the reference genes best suited for experiments that induce osteogenic differentiation from human induced pluripotent stem cells. They were cultured in an undifferentiated maintenance medium and after confluence, further cultured in an osteogenic differentiation medium for 28 days. RT-qPCR was performed on undifferentiation markers, osteoblast and osteocyte differentiation markers, and reference gene candidates. The expression stability of each reference gene candidate was ranked using four algorithms. General rankings identified TATA box binding protein in the first place, followed by transferrin receptor, ribosomal protein large P0, and finally, beta-2-microglobulin, which was revealed as the least stable. Interestingly, universally used GAPDH and ACTB were found to be unsuitable. Our findings strongly suggest a need to evaluate the expression stability of reference gene candidates for each experiment.博士（医学）・甲第770号・令和3年3月15日© The Author(s) 2020 : Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Totally Laparoscopic Gastrectomy for Gastric Cancer Associated with Recklinghausen's Disease

This paper documents the first case of gastric cancer associated with Recklinghausen's disease, which was successfully treated by a totally laparoscopic operation. A 67-year-old woman with Recklinghausen's disease was referred to this department to undergo surgical treatment for early gastric cancer. The physical examination showed multiple cutaneous neurofibromas throughout the body surface, which made an upper abdominal incision impossible. Laparoscopic surgery requiring only small incisions was well indicated, and a totally laparoscopic distal gastrectomy with lymph node dissection was performed. Billroth I reconstruction was done intra-abdominally using a delta-shaped anastomosis. The patient followed a satisfactory postoperative course with no complications. Since the totally laparoscopic gastrectomy has many advantages over open surgery, it should therefore be preferentially used as a less invasive treatment in the field of gastric cancer

Prognostic significance of nonsustained ventricular tachycardia in patients receiving cardiac resynchronization therapy for primary prevention: Analysis of the Japan cardiac device treatment registry database

BackgroundWhether nonsustained ventricular tachycardia (NSVT) is a marker of increased risk of sustained ventricular tachyarrhythmias (VTAs) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator (CRT‐D) for primary prevention.MethodsAmong the follow‐up data of the Japan cardiac device treatment registry (JCDTR) with an implantation date between January 2011 and August 2015, information regarding a history of NSVT before the CRT‐D implantation for primary prevention had been registered in 269 patients. Outcomes were compared between two groups with and without NSVT: NSVT group (n = 179) and No NSVT group (n = 90).ResultsThere was no significant difference with regard to age, gender, and NYHA class between the two groups. Left ventricular ejection fraction (LVEF) was 25.6% in the NSVT group and 28.0% in the No NSVT group (P = .046). The rate of appropriate therapy at 24 months was 26.0% and 18.4% in the NSVT and No NSVT groups (P = .22), respectively. Survival free from heart failure death was reduced in the NSVT group, as compared with the No NSVT group, with the rate of 90.2% vs 97.2% at 24 months (P = .030). A multivariate analysis identified a history of NSVT, anemia, and no use of angiotensin‐converting enzyme inhibitor (ACEI) or angiotensin‐receptor blocker (ARB) as predictors of heart failure death.ConclusionsNSVT appears to be a surrogate marker of severe heart failure rather than a substrate for subsequent sustained VTAs in patients with CRT‐D for primary prevention