Standard Model Higgs Searches at the LHC

An overview of the searches for the Standard Model Higgs boson at the LHC is presented. The main Higgs production and decay modes that have been studied are introduced, and the analysis techniques and the recent developments done by the ATLAS and CMS experiments are described. Some preliminary results from current studies are included. The discovery potential within the first few years of physics running is evaluated.Comment: Invited talk at the Hadron Collider Physics Symposium (HCP2008), Galena, Illinois, USA, May 27-31, 2008; 9 pages, LaTeX, 13 eps figures, typo corrected, reference detaile

The localization of VAMP5 in skeletal and cardiac muscle

学位記番号：医博甲152

読解過程における音読と黙読の役割 : 音韻情報の処理に着目した実験的検討

学位の種別:論文博士University of Tokyo(東京大学

Effectiveness of Anti-PD-1 Antibody Monotherapy for the Primary Malignant Melanoma of the Esophagus： A Case Report

Primary malignant melanoma of the esophagus（PMME）is extraordinarily rare with a high degree of malignancy and poor prognosis, and a standard therapy remains to be established. The anti-PD-1 antibody nivolumab is a promising agent for various cancers. To our knowledge, this is the first case report of PMME where a complete response was achieved using nivolumab. We report an 80-year-old woman who was diagnosed with PMME with bone metastasis and lymph node metastases. Although dacarbazine combined chemotherapy was performed and continued for six cycles, the primary tumor progressed and liver metastases appeared. The patient then received nivolumab monotherapy. After three cycles, nivolumab monotherapy for PMME resulted in a complete response as shown by positron emission tomography, computed tomography, and esophagogastroduodenoscopy. In our case, nivolumab exerted a curative effect on PMME, thus suggesting that nivolumab can be effective in the treatment of this rare disease

Theracurmin inhibits intestinal polyp development in Apc‐mutant mice by inhibiting inflammation‐related factors

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Therefore, it is important to establish useful methods for preventing CRC. One prevention strategy involves the use of cancer chemopreventive agents, including functional foods. We focused on the well‐known cancer chemopreventive agent curcumin, which is derived from turmeric. However, curcumin has the disadvantage of being poorly soluble in water due to its high hydrophobicity. To overcome this problem, the formation of submicron particles with surface controlled technology has been applied to curcumin to give it remarkably improved water solubility, and this derived compound is named Theracurmin. To date, the preventive effects of Theracurmin on hereditary intestinal carcinogenesis have not been elucidated. Thus, we used Apc‐mutant mice, a model of familial adenomatous polyposis, to evaluate the effects of Theracurmin. First, we showed that treatment with 10‐20 µM Theracurmin for 24 hours reduced nuclear factor‐κB (NF‐κB) transcriptional activity in human colon cancer DLD‐1 and HCT116 cells. However, treatment with curcumin mixed in water did not change the NF‐κB promoter transcriptional activity. As NF‐κB is a regulator of inflammation‐related factors, we next investigated the downstream targets of NF‐κB: monocyte chemoattractant protein‐1 (MCP‐1) and interleukin (IL)‐6. We found that treatment with 500 ppm Theracurmin for 8 weeks inhibited intestinal polyp development and suppressed MCP‐1 and IL‐6 mRNA expression levels in the parts of the intestine with polyps. This report provides a proof of concept for the ongoing Theracurmin human trial (J‐CAP‐C study)

Conversion of FeCo from soft to hard magnetic material by lattice engineering and nanopatterning

The development of magnetic materials with large uniaxial magnetic anisotropy (K-u) and high saturation magnetization has attracted much attention in various areas such as high-density magnetic storage, spintronic devices, and permanent magnets. Although FeCo alloys with the body-centred cubic structure exhibit the highest M-s among all transition metal alloys, their low K-u and coercivity (H-c) make them unsuitable for these applications. However, recent first-principles calculations have predicted large K-u for the FeCo films with the body-centred tetragonal structure. In this work, we experimentally investigated the hard magnetic properties and magnetic domain structures of nanopatterned FeCo alloy thin films. As a result, a relatively large value of the perpendicular uniaxial magnetic anisotropy K-u = 2.1 x 10(6) J.m(-3) was obtained, while the H-c of the nanopatterned FeCo layers increased with decreasing dot pattern size. The maximum H-c measured in this study was 4.8 x 10(5) A.m(-1), and the corresponding value of mu H-0(c) was 0.60 T, where mu(0) represented the vacuum permeability