The Effect of 8-week Aerobic and Concurrent (aerobic- resistance) Exercise Training on Serum IL-6 Levels and Insulin Resistance in Type 2 Diabetic Patients

Introductoin: Increased level of serum IL-6 is related to development of type 2 diabetes and insulin resistance. The American Diabetes Association and the American College of Sports Medicine recommend that combination of resistance and aerobic exercise is favorable for patients with type 2 diabetes. The purpose of this study was to investigate the effect of 8 weeks of aerobic exercise and concurrent (aerobic-resistance) exercise on serum IL-6 Levels and insulin resistance in Type 2 Diabetic patients. Methods: In this study, from patients referring to Kermanshah Diabetes Association, 24 volunteers participated in the study as subjects and were divided into aerobic (n=8), concurrent (n=8), and control group (n=8) randomly. Training program for the aerobic group included 3 sessions of running per week with 60 to 80% maximal heart rate for 8 weeks but the concurrent group in addition to running, performed resistance training of major muscles groups. Before and after the intervention, body weight, BMI, fasting blood glucose, serum IL-6 and HOMA-IR were measured. Results: HOMA-IR and fasting blood glucose were significantly decreased in both training groups after intervention, but showed no significant changes in the control group. No significant changes were observed for serum IL-6 levels, body weight or BMI. Conclusion: performing 8 weeks of aerobic or concurrent training with improvement of insulin resistance and fasting blood glucose could be helpful for type 2 diabetic patients; however, it cannot significantly affect serum IL-6 levels, body weight, or BMI in these patients

Comparison of the effect of 8 weeks of aerobic and combined training on serum levels of leptin and glucose in type 2 diabetic men

Background and Objective: Leptin has a key role in obesity and type 2 of diabetes. This study was done to compare the effects of eight weeks aerobic and combined training on serum levels of leptin and glucose in type 2 diabetic men. Method: This clinical trial study was performed on 24 men with type 2 diabetes whom reffered to Taleghani Hospital in Kermanshah, West of Iran during June to August 2012. The patients were randomly divided into 3 groups including aerobic training, combined training (aerobic and resistance training) and control groups. Training protocols included three 1-hour sessions per week for eight weeks. Subjects in the control group did not participate in any physical activities. Serum levels of leptin and glucose were measured 48 hours before and 48 hours after intervention as fasting values in pre-and post-tests. Results: There was no significant difference between groups at pre-test for serum levels of leptin and glucose. After intervention, serum level of glucose in the aerobic group and serum level of glucose and leptin in the combined group were significantly reduced in compared to the controls (P<0.05). Conclusion: Aerobic and combined training with beneficial effects on the sera glucose level are recommended for patients with type 2 diabetes. However, combined training, regarding reducing leptin level seems to be more useful for these subjects