1 research outputs found
PENGARUH KOMPOSISI LIPID PADA NANOSTRUCTURED LIPID CARRIERS (NLC) TERHADAP KARAKTERISTIK DAN EFEKTIVITAS UBIQUINONE DALAM SEDIAAN KOSMETIKA ANTIAGING
The purpose of this research is to determine the optimum composition of solid
lipid and liquid lipid in order to increase the penetration and effectiveness of Q10
as antioxidant in anti-aging cosmetics. Solid lipid and liquid lipid used in this
study were cetyl palmitate and caprylic, which were combined to four (4) different
ratios, namely 10:0; 9:1; 7:3 and 5:5. NLC Q10 in this study was produced by
high shear homogenization method at 3400 rpm for 5 cycles and at 24000 for 1
cycle. The fourth formula was evaluated in term of characteristics, penetration and
effectiveness. From the pH test , it was known that all formulas met the skin pH
range (4.0-6.0). For the particle size test , all formulas (NLC 1 - NLC 4) were in
the range from 269.13 to 354.77 nm with NLC 3 (7: 3) had the smallest particle
size. The results of viscosity and surface tension test were also consistent with the
theory, where the addition of liquid lipid reduced viscosity and surface tension of
the system. The entrapment efficiency (EE) demonstrated the EE of NLC 1:
22.24%; NLC 2: 24.71%; NLC 3: 58.21% and NLC 4: 36.94%. The penetration
test showed all systems were able to penetrate the dermis layer at the 5th hour.
NLC 3 (7: 3) had more rapid onset, while the NLC Q10 with the ratio of lipid 9: 1,
had slower onset of action but can penetrate farther than the other NLC Q10
system. The result of Q10 effectiveness test showed NLC 2 (9:1) has lowest total
macrophage (23,33) and very dense collagen observation (score : 4). From this
research, it can be concluded that NLC 2 (9: 1) had the most optimal lipid
composition to increase the penetration and effectiveness of Q10 as an antioxidant
in anti-aging cosmetics