Touch based POMDP manipulation via sequential submodular optimization

Figure S1. 3D human lung tissue aggregates to study angiogenesis. To investigate the molecular background of angiogenesis, a three dimensional human lung tissue model was set up using three characteristic cell types of the lung. Namely, primary normal small airway epithelial cells (SAEC), normal human lung fibroblast (NHLF) or VEGF-A-GFP overexpressing human fibroblast (F11) and human microvascular endothelial cells lung subtype (HMVEC-L). GFP aided the visualization of VEGF-A overexpressing fibroblasts in the core of the lung model. Actin was labeled by Alexa Fluor 568 conjugated phalloidin (Thermo Fisher Scientific, Waltham, USA) to detect all cells in the tissue. Scale bar, 200 Οm. (TIF 1897 kb